Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms

Torres‐Fuentes, Cristina; Suárez, Manuel; Aragonès, Gerard; Mulero, Miquel; Ávila-Román, Javier; Arola‐Arnal, Anna; Salvadó, M. Josepa; Arola, Lluı́s; Muguerza, Begoña

doi:10.1002/mnfr.202100990

Cited by 18 publications

(12 citation statements)

References 191 publications

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“…Phenolic compounds and their effects on circadian rhythms is a recent frontier in chrononutrition. [ 34 , 35 , 36 , 37 ] It is known that GSPE acts as a non‐photic cue in the hypothalamus and on the peripheral clock, significantly modifying the expression of Bmal1 and Nampt in the liver of rats exposed to 6‐h jet lag. [ 38 ] GSPE counteracted the rhythm disruption produced by a 6‐h jet lag and thus, the clock genes recovered their normal rhythmicity.…”

Section: Resultsmentioning

confidence: 99%

Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs

Manocchio

Soliz‐Rueda

Ribas‐Latre

et al. 2022

Molecular Nutrition Food Res

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Scope: Circadian rhythm is an endogenous and self-sustained timing system, responsible for the coordination of daily processes in 24-h timescale. It is regulated by an endogenous molecular clock, which is sensitive to external cues as light and food. This study has previously shown that grape seed proanthocyanidins extract (GSPE) regulates the hepatic molecular clock. Moreover, GSPE is known to interact with some microRNAs (miRNAs). Therefore, the aim of this study is to evaluate if the activity of GSPE as modulator of hepatic clock genes can be mediated by miRNAs. Methods and results: 250 mg kg −1 of GSPE is administered to Wistar rats before a 6-h jet lag and sacrificed at different time points. GSPE modulated both expression of Bmal1 and miR-27b-3p in the liver. Cosinor-based analysis reveals that both Bmal1 and miR-27b-3p expression follow a circadian rhythm, a negative interaction between them, and the role of GSPE adjusting the hepatic peripheral clock via miRNA. Additionally, in vitro studies show that Bmal1 is sensitive to GSPE (25 mg L −1 ). However, this effect is independent of miR-27b-3p. Conclusion: miRNA regulation of peripheral clocks via GSPE may be part of a complex mechanism that involves the crosstalk with the central system rather than a direct effect.

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Section: Resultsmentioning

confidence: 99%

Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs

Manocchio

Soliz‐Rueda

Ribas‐Latre

et al. 2022

Molecular Nutrition Food Res

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“…The positive effect of polyphenols on CVD is mainly related with their possibility of improving lipid metabolism, decreasing inflammatory signaling, and helping in the regeneration of vascular endothelium. In addition, they reduce the oxidative stress and have a positive effect on survival signaling, calcium homeostasis, and sirtuin (SIRT) activity (Kiyimba et al., 2023; Torres‐Fuentes et al., 2022).…”

Section: Cardioprotective Effectmentioning

confidence: 99%

The role of dietary polyphenols in the control of chronic noncommunicable diseases

Armas Díaz,

Ferreiro Cotorruelo,

Battino

2023

Food Safety and Health

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Noncommunicable chronic diseases (NCDs) are among the leading causes of death and disability worldwide. The most common NCDs are cancer, obesity, cardiovascular diseases, and diabetes. Nowadays, they represent one of the greatest challenges health systems face worldwide. The increase in the consumption of polyphenol‐rich foods could contribute to the reduction of these pathologies, due to their antioxidant, anti‐inflammatory, anticancer, immunomodulatory, and cardiovascular protective properties, among others. This review aims to highlight some studies carried out in recent years to enhance the possible benefits of a diet rich in polyphenols in the prevention or treatment of NCDs.

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“…Moreover, collagen hydrolysates have demonstrated to exert both angiotensin-converting enzyme-inhibitory (ACEi) and antihypertensive activities [ 18 , 20 , 21 ]. ACE inhibition is a usual and effective methodology to search for antihypertensive peptides [ 5 , 22 , 23 ] as this enzyme plays an important role in BP regulation [ 24 ]. In fact, ACE inhibitors are first-line treatments for HTN as they effectively decrease BP [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides

et al. 2023

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Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses.

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Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms

Cited by 18 publications

References 191 publications

Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs

Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs

The role of dietary polyphenols in the control of chronic noncommunicable diseases

Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides

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