Cardioprotective, hypotensive and toxicological studies of Populus ciliata (Wall. ex Royle)

Saqib, Fatima; Ali, Asghar; Ahmedah, Hanadi Talal; Irimie, Claudia Alexandrina; Toma, Sebastian; Popovici, Bianca; Moga, Marius; Irimie, Marius

doi:10.1016/j.biopha.2021.112065

Cited by 7 publications

(4 citation statements)

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“…A high quantity of flavonoids in plants was reported to be responsible for their cardioprotective effect [ 21 , 22 ], and P. rubra leaf extract was observed to be affluent in flavonoid content ( Table 1 ), [ 13 ]. As a result, it stands to reason that the early research [ 28 ] found that the aqueous-methanolic leaf extract of P. rubra had a significant LPO inhibitory effect, which supports its potential as a cardioprotective agent, because LPO is a main contributory factor in ADR-intoxicated MI [ 1 , 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The vasodilator effect of P. rubra may depend on blocking these voltage-gated L-type calcium channels ( Figure 7 ), as vasorelaxation was observed at a lesser concentration against K + (80 mM)-induced contraction than PE (1 μM)-induced contraction. The compounds relaxed by the K + (80 mM)-caused contraction are believed to be calcium channel blockers [ 1 , 5 , 6 ]. The negative ionotropic and chronotropic response was evident during the ex vivo investigation, similar to verapamil ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…Cardiovascular disease (CVD) is defined as a set of heart and blood vessel abnormalities that comprise congestive heart failure (CHF), myocardial infarction (MI), peripheral arterial disease (PAD), angina of different types, and coronary heart disease (CHD) [ 1 ]. Globally, hypertension is the primary cause of death in humans [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…It leads to an increased production of nitrosative derivatives, which cause the overproduction of ROS and, as a result, the myocardium faces immense oxidative stress [ 9 ]. It increases Ca ++ upsurge by opening L-type calcium channels on cardiomyocytes, and raises oxidative stress by escalating workload [ 1 ]. It causes aortic and coronary vasoconstriction at higher doses, and enhances blood coagulation by increasing clotting factor VIII, fibrinolysis, and platelet count [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders

et al. 2021

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Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechanisms. Ex vivo vaso-relaxant effects of crude leaf extract of P. rubra were observed in rabbit aorta ring preparations. Hypotensive effects were measured using pressure and force transducers connected to the Power Lab data acquisition system. Furthermore, P. rubra displayed cardioprotective properties in rabbits when they were exposed to adrenaline-induced myocardial infarction. In comparison to the intoxicated group, the myocardial infarction model showed decreased troponin levels, CK-MB, LDH, ALT, ALP, AST, and CRP, as well as necrosis, apoptosis, oedema, and inflammatory cell enrollment. P. rubra has revealed good antioxidant properties and prolonged the noradrenaline intoxicated platelet adhesion. Its anticoagulant, vasorelaxant, and cardioprotective effects in both in vivo and ex vivo investigations are enabled by blocking L-type calcium channels, lowering adrenaline, induced oxidative stress, and tissue tear, justifying its therapeutic utility in cardiovascular disorders.

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