Cardioprotective effects of the YiQiFuMai injection and isolated compounds on attenuating chronic heart failure via NF-κB inactivation and cytokine suppression

Xing, Lianxi; Jiang, Min; Dong, Linyi; Gao, Jie; Hou, Yuanyuan; Bai, Gang; Luo, Guangsheng

doi:10.1016/j.jep.2013.04.019

Cited by 56 publications

(38 citation statements)

References 31 publications

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“…The overproduction of inflammatory factors, especially TNF-α and IL-6, could cause a decrease in cardiac systolic potential and cardiac output. The two factors could cause necrosis and apoptosis of cardiomyocytes and contribute to myocardial remodeling, resulting in worsening of CHF [5,12]. The levels of TNF-α and IL-6 were evaluated in our study, showing that treatment with DYFX significantly suppressed the inflammation response via by decreasing the levels of TNF-α and IL-6 in CHF rats.…”

Section: Discussionmentioning

confidence: 64%

“…However, these treatments are because of their side effects including damage to the liver, kidney, and gastrointestinal tract [5,6]. Traditional Chinese medicine (TCM) has shown efficacy in treating complex multi-factor diseases, because TCM is a unique medical system that uses drugs with multiple components that have synergistic therapeutic efficacies [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Cardioprotective effects of <i>Dan-Yang-Fu-Xin</i> decoction on chronic heart failure in rats

Guan¹,

Chen²,

Yang³

2016

Trop. J. Pharm Res

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Purpose: To evaluate the cardioprotective effects and possible mechanisms of Dan-Yang-Fu-Xin decoction (DYFX) in a rat chronic heart failure (CHF). Methods: A CHF rat model induced by ligation of the left anterior descending coronary artery was used to investigate the cardioprotective effects of DYFX. After intragastric administration for 8 weeks, several functional cardiac indices, including fractional shortening (FS), ejection fraction (EF), heart rate (HR) and cardiac output (CO) were assessed by ultrasound examination. Subsequently, inflammatory markers, viz, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), myocardial enzymes, namely, lactate dehydrogenase (LDH) and creatine kinase (CK), were also assessed by enzyme-linked immunosorbent assay (ELISA). Results: Intragastric administration of DYFX (200, 400 and 600 mg/kg) significantly reversed the decrease in body weight and increase in cardiac weight (p < 0.05) induced by CHF. Treatment with DYFX also significantly reversed EF, FS, HR, and CO changes in CHF rats. In addition, DYFX inhibited the two inflammatory cytokines and myocardial enzymes (CK and LDH)

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of <i>Dan-Yang-Fu-Xin</i> decoction on chronic heart failure in rats

Guan¹,

Chen²,

Yang³

2016

Trop. J. Pharm Res

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“…NF-κB also interacts with and regulates many molecules, including TNF-α, IL-1β, IL-2, IL-6, and IL-8. In our previous study, we developed a bioactivity-integrated UPLC-Q/TOF protocol for identifying NF-κB inhibitors [17], [18]. PCA is a multivariate statistical method used to distinguish chemical components using cluster analysis and a factorial k-means analysis of relatively large data sets acquired from HPLC-DAD, UPLC-MS and spectroscopic techniques [19], [20].…”

Section: Discussionmentioning

confidence: 99%

The Screening Research of Anti-Inflammatory Bioactive Markers from Different Flowering Phases of Flos Lonicerae Japonicae

et al. 2014

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Flos Lonicerae Japonicae (FLJ) is an important cash crop in eastern Asia, and it is an anti-inflammatory Traditional Chinese Medicine. There are large variations in the quality of the marketed FLJ products. To find marker ingredients useful for quality control, a tandem technology integrating ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF), principal component analysis (PCA), heat map analysis and hierarchical cluster analysis coupled with a NF-κB luciferase reporter gene assay were used to identify the different ingredients from the green bud, white bud, flowering stage and leaf stages, as well as to screen the anti-inflammatory activity of FLJ compositions. As flowering progressed, the anti-inflammatory effects of FLJ gradually decreased; however, chlorogenic acid, swertiamarin and sweroside should be used to evaluate the quality of FLJ products.

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“…He et al [34] reported no significant effect of G-Rh1 in the range of 0.1-10 µM on the activity of NF-κB luciferase reporter activity in human embryonic kidney 293 (HEK 293) cells induced by TNF-α (10 ng/mL). However, significant inhibition of NF-κB activation by G-Rh1 was also reported in HEK 293 cells pretreated with TNF-α [35], in BV2 glioma cells induced by LPS [36] or IFN-γ [37], in macrophages stimulated by LPS or TNBS [38], and in murine macrophage RAW 264.7 cells treated with LPS [39] or TNF-α [22]. Both He et al [34] and Xing et al [35] assessed the protective effect of G-Rh1 on the activation of NF-κB on HEK 293 cells induced by TNF-α.…”

Section: Anticancer Effectsmentioning

confidence: 91%

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

et al. 2018

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Supporting information available online at http://www.thieme-connect.de/products ABSTR AC TGinsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

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Cardioprotective effects of the YiQiFuMai injection and isolated compounds on attenuating chronic heart failure via NF-κB inactivation and cytokine suppression

Cited by 56 publications

References 31 publications

Cardioprotective effects of <i>Dan-Yang-Fu-Xin</i> decoction on chronic heart failure in rats

Cardioprotective effects of <i>Dan-Yang-Fu-Xin</i> decoction on chronic heart failure in rats

The Screening Research of Anti-Inflammatory Bioactive Markers from Different Flowering Phases of Flos Lonicerae Japonicae

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

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