Cardioprotective effects of S-equol and role of the PI3K/Akt pathway in the isolated ischemic rat heart
Mariko Yamada,
Yosuke Nakadate,
Keisuke Omiya
et al.
Abstract:Purpose
This study aimed to assess the cardioprotective effects of S-equol on stunned myocardium in an isolated rat heart model. Additionally, we examined the role of the PI3K/Akt signaling pathway.l
Methods
Rat hearts were perfused using the Langendorff system and assigned to receive 1) modified Krebs–Henseleit (KH) buffer containing 1 µmol/L S-equol (EQ), 2) KH buffer (Cont), 3) KH buffer supplemented with 1 µmol/L S-equol and 100 nmol/L wortmannin (a specific PI3K inhibitor) (EQW), or 4) KH buffer contain… Show more
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