Cardioprotective Effects of Omega-3 Polyunsaturated Fatty Acids: Dichotomy between Experimental and Clinical Studies

Desnoyers, Mélissa; Kim, Gilbert; Rousseau, Guy

doi:10.3390/md16070234

Cited by 24 publications

(16 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies described a mean individual intake of seven or more meals of 141 g of fish per week [ 24 ]. Although fish is a known source of ω-3 and ω-6 fatty acids, elements with a cardio-protective function [ 50 ], in the Amazon, it is frequently contaminated with mercury, especially the piscivorous species [ 5 , 26 , 51 ]. In both regions, the riverine inhabitants reported consuming piscivorous fish, such as “tucunaré” (peacock bass, Cichla spp.)…”

Section: Discussionmentioning

confidence: 99%

Eating in the Amazon: Nutritional Status of the Riverine Populations and Possible Nudge Interventions

Machado

Crespo-López

Augusto-Oliveira

et al. 2021

Foods

View full text Add to dashboard Cite

The Amazon is the largest tropical forest in the world and a source of healthy food, such as fruits and fish. Surprisingly, the Amazonian riverine population present an increased prevalence (as high as 58%) of non-communicable diseases, such as hypertension and insulin resistance, even higher than that described for the urban population of the Amazon. Therefore, this work aimed to analyze the nutritional status and associated risk of the riverine population. Body mass index, waist circumference (WC), waist-to-hip ratio, and neck circumference (NC) were evaluated, and risk analysis was assayed. Furthermore, data about occupation and the prevalence of consumers of the different groups of food were analyzed. All anthropometric parameters revealed high proportions of individuals at risk, WC and NC being the factors that had more high-risk women and men, respectively. Our data confirmed the characteristic profile of the riverine communities with a high number of fish consumers, but also observed different patterns probably associated to a phenomenon of nutrition transition. Based on our data, some nudge interventions that take into account the principles of behavior analysis are discussed and proposed for these populations, aiming to improve the nutritional status and avoid the long-term consequences of the results showed by this work.

show abstract

Section: Discussionmentioning

confidence: 99%

Eating in the Amazon: Nutritional Status of the Riverine Populations and Possible Nudge Interventions

Machado

Crespo-López

Augusto-Oliveira

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…The data of the current study revealed an improvement in ECG, cardiac and renal function biomarkers and histopathological findings by OMG in DOX-treated rats. Several mechanisms of cardio- and reno- protective effects of OMG against different heart and kidney diseases have been reported, including their advantage on platelet function, cytokine production, fibrinolysis, and inflammatory factors [ 68 – 71 ]. Moreover, the present study confirmed the established anti-oxidant and anti-apoptotic activity of OMG [ 72 – 74 ] by showing an improvement in oxidative and apoptotic biomarkers in both heart and kidney tissues of DOX-injected rats when pretreated with OMG.…”

Section: Discussionmentioning

confidence: 99%

Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy

et al. 2020

View full text Add to dashboard Cite

This study examines the protective effects of omega‐3 fatty acids (OMG), a frequently used nutritional therapy in cancer patients, against doxorubicin (DOX)‐induced acute cardiorenal toxicity in rats, and evaluates the cytotoxic activity of DOX when used with OMG against breast cancer cell line. Five groups of rats were treated for 4 consecutive weeks with vehicle (groups I & II), or OMG (25, 50 or 100 mg/kg/day, po; groups III, IV & V, respectively). After twenty-four hours, the last four groups were injected with DOX (200 mg/kg, ip). In DOX-treated rats, the altered ECG, serum cardiac and renal function biomarkers, and histopathological features indicated the induction of cardiorenal toxicity. Increased oxidative and apoptotic markers in both organs was observed, with elevated renal contents of NADPH-oxidase-4 (Nox4) and renin. OMG pretreatment improved those DOX-induced impairments in a dose-dependent manner, and showed antioxidant and antiapoptotic effects with regulation of renal Nox4 expression. The in-vitro study showed preservation of the cytotoxic activity of DOX on MCF7 cell line in the presence of OMG. The data suggests OMG for protection against acute DOX‐induced cardiorenal damage without affecting the latter antitumor activity. It proposes regulation of oxidative stress, Nox4 activity and apoptosis as contributing protective mechanisms.

show abstract

“…There is a general consensus that omega3-PUFA compete with omega6-PUFA in the metabolic pathways involving the same enzymes, namely, COXs, LOX and CYTP, and their metabolites (omega3 eicosanoids) are less active and are more anti-inflammatory than their omega6 counterparts. In fact, a diet rich in omega3-PUFA is associated with health benefits in prevention and outcome of different diseases [104,105]. Dumlao et al have evaluated the effect of diet rich in omega3-and omega6-PUFA on Lyme arthritis in a mouse model [106].…”

Section: Influence Of Host Diet and Lifestyle: Hypercholesterolemia Amentioning

confidence: 99%

Lyme Disease Frontiers: Reconciling Borrelia Biology and Clinical Conundrums

Bamm

Mainprize

et al. 2019

Pathogens

View full text Add to dashboard Cite

Lyme disease is a complex tick-borne zoonosis that poses an escalating public health threat in several parts of the world, despite sophisticated healthcare infrastructure and decades of effort to address the problem. Concepts like the true burden of the illness, from incidence rates to longstanding consequences of infection, and optimal case management, also remain shrouded in controversy. At the heart of this multidisciplinary issue are the causative spirochetal pathogens belonging to the Borrelia Lyme complex. Their unusual physiology and versatile lifestyle have challenged microbiologists, and may also hold the key to unlocking mysteries of the disease. The goal of this review is therefore to integrate established and emerging concepts of Borrelia biology and pathogenesis, and position them in the broader context of biomedical research and clinical practice. We begin by considering the conventions around diagnosing and characterizing Lyme disease that have served as a conceptual framework for the discipline. We then explore virulence from the perspective of both host (genetic and environmental predispositions) and pathogen (serotypes, dissemination, and immune modulation), as well as considering antimicrobial strategies (lab methodology, resistance, persistence, and clinical application), and borrelial adaptations of hypothesized medical significance (phenotypic plasticity or pleomorphy).

show abstract

Cardioprotective Effects of Omega-3 Polyunsaturated Fatty Acids: Dichotomy between Experimental and Clinical Studies

Cited by 24 publications

References 62 publications

Eating in the Amazon: Nutritional Status of the Riverine Populations and Possible Nudge Interventions

Eating in the Amazon: Nutritional Status of the Riverine Populations and Possible Nudge Interventions

Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy

Lyme Disease Frontiers: Reconciling Borrelia Biology and Clinical Conundrums

Contact Info

Product

Resources

About