Cardioprotective effects of omega 3 fatty acids: origin of the variability

Roy, Jérôme; Guennec, Jean‐Yves Le

doi:10.1007/s10974-016-9459-z

Cited by 15 publications

(9 citation statements)

References 76 publications

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“…Omega-3 FAs are pivotal not only for brain function and normal growth and development (Belluzzi, 2002) but also they have many beneficial effects on several health problems including cardiac diseases (Roy and Le Guennec, 2017;Endo and Arita, 2016) which confirm the present results of restoring the cardiac muscle architecture after addition of omega-3.…”

Section: Discussionsupporting

confidence: 89%

Effect of Formaldehyde on The Structure of The Lung and Heart and The Possible Protective Effect of Omega- 3 (Histological and immune-histochemical study)

Ouies

AbdEL-Naeem

2020

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Section: Discussionsupporting

confidence: 89%

Effect of Formaldehyde on The Structure of The Lung and Heart and The Possible Protective Effect of Omega- 3 (Histological and immune-histochemical study)

Ouies

AbdEL-Naeem

2020

Egyptian Academic Journal of Biological Sciences, B. Zoology

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“…Molecular and cellular research shows that n-3 PUFAs have cardioprotective effects [23]. A diet rich in n-3 PUFAs has a beneficial effect on blood pressure, heart rate, left ventricular diastolic filling, and endothelial functions [24].…”

Section: Mitochondrial Oxidative Stress and N-3 Pufasmentioning

confidence: 99%

The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection

et al. 2020

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Polyunsaturated fatty acids (n-3 PUFAs) are long-chain polyunsaturated fatty acids with 18, 20 or 22 carbon atoms, which have been found able to counteract cardiovascular diseases. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in particular, have been found to produce both vaso- and cardio-protective response via modulation of membrane phospholipids thereby improving cardiac mitochondrial functions and energy production. However, antioxidant properties of n-3 PUFAs, along with their anti-inflammatory effect in both blood vessels and cardiac cells, seem to exert beneficial effects in cardiovascular impairment. In fact, dietary supplementation with n-3 PUFAs has been demonstrated to reduce oxidative stress-related mitochondrial dysfunction and endothelial cell apoptosis, an effect occurring via an increased activity of endogenous antioxidant enzymes. On the other hand, n-3 PUFAs have been shown to counteract the release of pro-inflammatory cytokines in both vascular tissues and in the myocardium, thereby restoring vascular reactivity and myocardial performance. Here we summarize the molecular mechanisms underlying the anti-oxidant and anti-inflammatory effect of n-3 PUFAs in vascular and cardiac tissues and their implication in the prevention and treatment of cardiovascular disease.

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“…However, unlike these drugs, omega-3 PUFAs are rarely proarrhythmic. A modulation of intracellular calcium handling by omega-3 PUFAs, including inhibition of sarcoplasmic reticulum RyR channels, and prevention of calcium overload may abolish or attenuate arrhythmia triggers [ 57 , 58 , 59 ].…”

Section: Potential Targets Of Omega-3 Pufas Relevant To Arrhythmiamentioning

confidence: 99%

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs

et al. 2017

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Omega-3 polyunsaturated fatty acids (PUFAs), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are permanent subjects of interest in relation to the protection of cardiovascular health and the prevention of the incidence of both ventricular and atrial arrhythmias. The purpose of this updated review is to focus on the novel cellular and molecular effects of omega-3 PUFAs, in the context of the mechanisms and factors involved in the development of cardiac arrhythmias; to provide results of the most recent studies on the omega-3 PUFA anti-arrhythmic efficacy and to discuss the lack of the benefit in relation to omega-3 PUFA status. The evidence is in the favor of omega-3 PUFA acute and long-term treatment, perhaps with mitochondria-targeted antioxidants. However, for a more objective evaluation of the anti-arrhythmic potential of omega-3 PUFAs in clinical trials, it is necessary to monitor the basal pre-interventional omega-3 status of individuals, i.e., red blood cell content, omega-3 index and free plasma levels. In the view of evidence-based medicine, it seems to be crucial to aim to establish new approaches in the prevention of cardiac arrhythmias and associated morbidity and mortality that comes with these conditions.

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Cardioprotective effects of omega 3 fatty acids: origin of the variability

Cited by 15 publications

References 76 publications

Effect of Formaldehyde on The Structure of The Lung and Heart and The Possible Protective Effect of Omega- 3 (Histological and immune-histochemical study)

Effect of Formaldehyde on The Structure of The Lung and Heart and The Possible Protective Effect of Omega- 3 (Histological and immune-histochemical study)

The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs

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