Cardioprotective effects of Ferulic acid against various drugs and toxic agents

Abstract

Background Homeostatic regulation of cardiomyocytes is indispensable in maintaining the normal physiological activity of cardiac tissue. Cardiotoxicity induced by drugs may lead to cardiac abnormalities such as arrhythmia, myocardial infarction and myocardial hypertrophy. Moreover, drug-induced cardiotoxicity confines the additional use of the implicated drugs. Several studies have reported that consumption of phytochemicals on regular intervals shall protect humans against numerous diseases such as diabetes, cardiovascular disease, inflammatory diseases and cancer. Main body Ferulic acid (FA) is a plant derived polyphenol abundantly found in vegetables, fruits and grains. FA is widely known for its antioxidant, anti-inflammatory, anticancer, nephroprotective and hepatoprotective effects. FA has been well documented for its cardioprotective activity against various drugs and toxic agents as well. However, the cardioprotective action of FA have remained a challenge with regard to understanding its mechanism in health and diseases. Conclusion The main purpose of this review is to explore the cardioprotective mechanisms of FA against several drugs and chemicals to recommend further studies to investigate the potential protective effect of FA.

Complementary nutritional and health promoting constituents in germinated and probiotic fermented flours from cowpea, sorghum and orange fleshed sweet potato

“…Likewise, Teixeira-Guedes et al 70 reported high ferulic acid in the extract from germinated cowpeas for 5 days. These bioactive acids have been documented to regulate and suppress reactive oxygen species-mediated pathological conditions 64 , 71 . More recently, improved lipid profiles and a consequent significant decrease in oxidised low-density lipoprotein-cholesterol, oxidative stress, and inflammatory biomarkers were the outcomes of administering a ferulic acid capsule (500 mg twice daily for 6 weeks) to hyperlipidemic patients 65 .…”

Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test

“…Ferulic acid (FA) ([E]−3-[4-hydroxy-3-methoxy-phenyl] prop-2-enoic acid) is a phenolic compound commonly found in some fruits ( Lorigooini et al, 2020b ). Numerous pharmacological properties have been reports for FA counting anti-inflammatory, antioxidant, anticancer, anxiolytic cardioprotective, neuroprotective and antidiabetes effects ( Nile et al, 2016 , Zheng et al, 2019 , Pandi et al, 2022 , Dong and Huang, 2022 ). It has been determined that FA through its anti-oxidant and anti-inflammatory properties exerted nephroprotective effects in cyclosporine-induced nephrotoxicity in rats ( Ghasemi-Dehnoo et al, 2023 ).…”

Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives

“…It rarely occurs in a free state and is typically conjugated with mono, oligosaccharides, polysaccharides, polyamines, and lipids. Multiple studies have shown a wide range of biological effects by FA against clinical conditions, including, cancer, diabetes, lung, and cardiovascular diseases [ 108 , 152 , 153 ]. It also shows hepatic, neuro, and photoprotective effects.…”