Cardioprotective Effects of Extracts from &lt;i&gt;Psidium guajava&lt;/i&gt; L. and &lt;i&gt;Limonium wrightii&lt;/i&gt;, Okinawan Medicinal Plants, against Ischemia-Reperfusion Injury in Perfused Rat Hearts

Yamashiro, Satoshi; Noguchi, Katsuhiko; Matsuzaki, Toshihiro; Miyagi, Koichi; Nakasone, Junko; Sakanashi, Mayuko; Kukita, Ichiro; Aniya, Yoko; Sakanashi, Matao

doi:10.1159/000067799

Cited by 52 publications

(26 citation statements)

References 20 publications

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“…One of the more abundant phenolic compounds in GB is quercetin [27], which would explain the pro-oxidant/antioxidant duality of the extract, as well as its potent DPPH-scavenging capacity. In a previous report, an extract of guava leaf was found to possess equipotent free radical scavenging activity to quercetin [28]. Unlike AN and PBI, however, GB exhibited a cytoprotective tendency and inhibited oxLDL cytotoxicity toward BAEC after 6 h (Figure 4), a property that is likely due to its content of the phenol (+)-gallocatechin.…”

Section: Pattern 2: Antioxidant Extracts With Cytoprotective Effectsmentioning

confidence: 79%

Endothelial cytoprotection from oxidized LDL by some crude melanesian plant extracts is not related to their antioxidant capacity

Owen

Matainaho

Sirois

et al. 2007

J Biochem & Molecular Tox

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Habitual consumption of some Melanesian medicinal and food plants may influence atherosclerosis development via their antioxidant capacity at the endothelial level. Areca nut (AN; Areca catechu), piper inflorescence (PBI; Piper betle), betel quid (BQ), guava buds (GB; Psidium guajava), the leaves (NL), juice (NJ), fruit (NF), and root (NR) of noni (Morinda citrifolia), the propagules of raw (MBR), and cooked (MBC) mangrove (Bruguiera gymnorrhiza) were evaluated for their ability to scavenge the 1,1-diphenyl-2-picryl-hydrazyle (DPPH) radical, to protect human low-density lipoprotein (LDL) from Cu2+-catalyzed oxidation and to protect cultured bovine aortal endothelial cells (BAEC) from oxidized LDL (oxLDL)-induced cytotoxicity. Polyphenol-rich extracts AN, PBI, and BQ were potent DPPH scavengers, having similar activity to quercetin and able to protect LDL from oxidation in a dose-dependent manner at concentrations higher than 10 microg/mL, but were pro-oxidants at lower concentrations. These extracts were cytotoxic to BAEC at concentrations above 10 microg/mL and were unable to prevent oxLDL endotheliopathy. GB and NR at 10 mug/mL displayed both the ability to delay LDL oxidation and prevent oxLDL cytotoxicity, although the latter lacked the ability to scavenge the DPPH radical. At higher concentrations, however, both were cytotoxic in themselves. The remaining noni extracts NF, NJ, NL, and both mangrove extracts MBC and MBR were unable to protect LDL from oxidation at all tested concentrations, but were effective cytoprotective agents at 50 microg/mL. All extracts were able to prevent an oxLDL-mediated increase in intracellular aldehyde generation but had little effect on extracellular peroxidation as measured by thiobarbituric acid reactive substances (TBARS). On the basis of this model system, we conclude that the antioxidant benefits of AN, PBI, and BQ may be offset by their enhancement of their cytotoxic effects of oxLDL toward BAEC, whereas GB and low concentrations of noni and mangrove may be considered antiatherogenic. The discrepancies between our in vitro and cellular culture experiments emphasize the importance of experimental conditions in evaluating the antioxidant potential of crude plant extracts.

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Section: Pattern 2: Antioxidant Extracts With Cytoprotective Effectsmentioning

confidence: 79%

Endothelial cytoprotection from oxidized LDL by some crude melanesian plant extracts is not related to their antioxidant capacity

Owen

Matainaho

Sirois

et al. 2007

J Biochem & Molecular Tox

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“…86 Quercetin and gallic acid is one of the major antioxidative bioactive compounds of P. guajava and Limonium wrightii, respectively. 87 The extracts P. guajava and L. wrightii significantly attenuated ischemic contracture during ischemia and also enhanced myocardial dysfunction after reperfusion. Increases in malondialdehyde (MDA) and decreases in high-energy phosphates in the reperfused hearts are significantly lessened with the both plant extracts.…”

Section: Cardioprotective and Hypotensive Activitymentioning

confidence: 97%

Phytopharmacological overview of Psidium guajava Linn.

Anand¹,

Manikandan²,

Kumar³

et al. 2016

Phcogj

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Psidium guajava Linn. possesses useful medicinal benefits. It has been recognized as the medicinally essential phytoconstituents, such as phenolic, flavonoid and carotenoid. Numerous pharmacological investigation have confirmed that the ability of this plant is to exhibit antimicrobial, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, antioxidant and anticancer activities and it supports the traditional uses. This is a comprehensive of the phytoconstituents and pharmacological benefits.

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“…Studies have also shown antifungal, anti-yeast, ant amebic and antimalarial functions (Somwyas et al, 2013). A study in 2003 with guinea pigs Brazillan researcher demonstrated that leaf extracts have various effects on cardiovascular system which may be beneficial in treating irregular arrhythmia (Yamashiro et al, 2003). Guava leaf provided antioxidant that protects the heart and improved d myocardial function.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity determination of methanol and water extracts for roots and leaves of Kenyan Psidium guajava L landraces against pathogenic bacteria

2013

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Guava (Psidium guajava L) is native to South America and exists as both wild and cultivated. Guava has been used as a source of food and raw materials for pharmaceuticals. The aim of this study was to determine bioactivity of methanol and water extracts from root and leaves of Kenyan guava landraces against selected pathogenic bacteria. Study samples were collected from Western and South Coast of Kenya. One hundred grams of leaf and root ground powders were used for sequential extraction using methanol and water. Extracts were evaporated and 0.2gms dissolved using the extraction solvent and tested against gram positive (Staphylococcus aureus, Bacillus subtilis) and negative bacteria (Escherichia coli). Data on inhibition zone was taken in mm and analyzed at 95% confidence interval. Extracts from Western region had significant inhibition compared to Coastal region. The two regions have different climatic conditions that result in these plants having different compounds even though they are the same species. Roots had higher inhibition compared to the leaves as they contain high levels of tannins compared to leaves. Water as an extracting solvent had higher inhibition than methanol as it is more polar and it absorbs more bioactive compounds. S. aureus was most inhibited followed by E. coli and B. subtilis respectively. There was no significant difference between the gram positive and negative bacteria. Remarkably, some methanol and water root extracts had significant inhibition against bacteria when compared to some commercial antibiotics used. Results of this study indicate that Kenyan guava roots from Western Kenya extracted with methanol and water have a potential to be used as a source of active compounds in treatment of gram positive and gram negative bacteria pathogens.

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Cardioprotective Effects of Extracts from <i>Psidium guajava</i> L. and <i>Limonium wrightii</i>, Okinawan Medicinal Plants, against Ischemia-Reperfusion Injury in Perfused Rat Hearts

Cited by 52 publications

References 20 publications

Endothelial cytoprotection from oxidized LDL by some crude melanesian plant extracts is not related to their antioxidant capacity

Endothelial cytoprotection from oxidized LDL by some crude melanesian plant extracts is not related to their antioxidant capacity

Phytopharmacological overview of Psidium guajava Linn.

Bioactivity determination of methanol and water extracts for roots and leaves of Kenyan Psidium guajava L landraces against pathogenic bacteria

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