Cardioprotective effects of bilberry extract on ischemia-reperfusion-induced injury in isolated rat heart

Žiberna, Lovro; Lunder, Mojca; Može, Špela; Vanzo, Andreja; Drevenšek, Gorazd

doi:10.1186/1471-2210-9-s2-a55

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…mg) during two months could contribute to explain the cardiovascular disease protective role of a diet rich in fruits and vegetables. Žiberna et al [78] observed that the administration of a V. myrtillus extract (0.01-5 mg/L) to rats increased coronary flow up to 2.5-fold, and decreased lactate dehydrogenase (LDH) release rate during reperfusion by 3.7-fold at 0.1 mg/L and by 6.7-fold at 1 mg/L, compared to controls. It was also effective in the prevention of arrhythmias, whose duration was maximally shortened at 0.1 mg/L to 3.2 ± 0.2 %, and at 1 mg/L to 4.4 ± 0.3 %, in relation to the untreated group.…”

Section: Cardioprotective Effectsmentioning

confidence: 99%

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Pires

Caleja

Santos‐Buelga

et al. 2020

CPD

View full text Add to dashboard Cite

: Consumers’ demand for healthier foods with functional properties has had a clear influence on the food industry and in this sense, they have been attaching natural sources of bioactive ingredients into food products. Vaccinium myrtillus L. (bilberry) is known to be a functional food, presenting its fruits in the form of a small dark blueberry. This coloration is due to its high content in anthocyanin, being also associated with bilberries’ beneficial health effects. In the bilberry industry, there is a very high annual loss of this fruit due to the less aesthetic shape or appearance, in which they cannot be considered suitable for sale and are therefore disposed of as biological waste. Therefore, it is of great importance to valorize this fruit and this review aimed to completely characterize the fruits of V. myrtillus in order to comprehend the relationship between their consumption and the beneficial effects regarding consumer’s health. Thus, this review provides a description of the nutritional and bioactive compounds present in bilberry fruits, followed by their beneficial health effects. An overview of the natural pigments present in these fruits was also explored, focusing particularly in the anthocyanins composition, which represents the most widely studied class of bioactive compounds of V. myrtillus fruits. Finally, industrial applications of these fruits and by-products, as an efficient approach to the production of value-added products with economical and environmental impact, were also discussed. : In general, V. myrtillus is a rich source of micronutrients and phytochemical compounds, such as organic acids, sugars, vitamins, fibers and phenolic compounds (anthocyanin and non-anthocyanin compounds), with nutritional and functional properties, that justify the growing interest in these berries, not only for food applications, but also in the pharmaceutical industry.

show abstract

Section: Cardioprotective Effectsmentioning

confidence: 99%

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Pires

Caleja

Santos‐Buelga

et al. 2020

CPD

View full text Add to dashboard Cite

show abstract

Cardioprotective Potential of Plant-Derived Molecules: A Scientific and Medicinal Approach

et al. 2019

View full text Add to dashboard Cite

Since the beginning of human civilization, plants have been used in alleviating the human distress and it was recorded for about thousands of years ago that the plants are being used for medicinal purposes. Natural bioactive compounds called phytochemicals are obtained from medicinal plants, vegetables, and fruits, which functions to combat against various ailments. There is dire need to explore the plant biodiversity for its medicinal and pharmacological potentials. Different databases such as Google scholar, Medline, PubMed, and the Directory of Open Access Journals were searched to find the articles describing the cardioprotective function of medicinal plants. Various substances from a variety of plant species are used for the treatment of cardiovascular abnormalities. The cardioprotective plants contain a variety of bioactive compounds, including diosgenin, isoflavones, sulforaphane, carotinized, catechin, and quercetin, have been proved to enhance cardioprotection, hence reducing the risk of cardiac abnormalities. The present review article provides the data on the use of medicinal plants particularly against cardiac diseases and to explore the molecules/phytoconstituents as plant secondary metabolites for their cardioprotective potential.

show abstract

Indian Plants with Cardioprotective Activity – A Review

Kumar¹,

Krishna²,

Hullatti³

et al. 2016

SRP

View full text Add to dashboard Cite

Cardio-protection includes" all mechanism and means that contribute to the preservation of the heart by reducing or even preventing Myocardial damage. Cardiovascular disease (CVD) remains the principle cause of death in both developed and developing countries. It may present as a typical heart attack, a sudden death or it may be detected at an advanced stage and be described as a silent infarct. CVD includes high blood pressure, coronary heart disease, congestive heart failure, stroke and accounts Myocardial infarction is the interruption of blood supply to part of the heart, causing heart cells to die, commonly due to blockage of coronary artery. Herbal drugs are known to exhibit creditable medicinal properties for the treatment of heart ailments and need to be explored to identify their potential application in prevention and therapy of human ailments. Cardio-vascular disease remains a leading cause of death in India. Therefore, finding ways to reduce the mortality of cardiovascular disease remains an important health goal. This review deals with medicinal plants possessing cardioprotective and cardio tonic activity. Cardiovascular disease is the number one cause of death globally and is projected to remain the leading cause of death. This review work explains chemical and pharmacological status of various cardio-protective plants including phyto constituents responsible for cardio-protection, extract employed, dosage, pharmacological screening model and mechanism involved in cardio-protection. This review work definitely helps in enlisting the Indian plants having cardioprotective activity.

show abstract

Cardioprotective effects of bilberry extract on ischemia-reperfusion-induced injury in isolated rat heart

Abstract: Background Bilberries (Vaccinium myrtillus L.) are recognized as a good source of flavonoids, especially anthocyanins, which have strong antioxidative activity. Therefore, they may have a strong potential as cardioprotective agents in ischemicreperfusion injury.

Cited by 4 publications

References 0 publications

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Cardioprotective Potential of Plant-Derived Molecules: A Scientific and Medicinal Approach

Indian Plants with Cardioprotective Activity – A Review

Contact Info

Product

Resources

About