Cardioprotective effect of vanillic acid against doxorubicin-induced cardiotoxicity in rat

Baniahmad, Bahar; Safaeian, Leila; Vaseghi, Golnaz; Rabbani, Mohammad; Mohammadi, Behnoosh

doi:10.4103/1735-5362.278718

Cited by 43 publications

(6 citation statements)

References 35 publications

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“…Despite the ingestion of the sucrose-based beverages provided the highest values of this metabolite in urine (24.16 µg/mg of creatinine), the intake of beverages developed using stevia as a sweetener, duplicated the basal values, providing the highest increase. This outcome is of special relevance, because of the association of this compound to anti-cancer, anti-obesity, anti-inflammatory, and cardioprotective features [ 33 , 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Beverages Based on Second Quality Citrus Fruits and Maqui Berry, a Source of Bioactive (Poly)phenols: Sorting Out Urine Metabolites upon a Longitudinal Study

2021

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The intake of sugar-sweetened beverages has been associated with an augmented prevalence of metabolic diseases, namely, obesity, type II diabetes, and metabolic syndrome. On the other hand, nowadays, it is broadly accepted that foods and beverages rich in (poly)phenols could contribute to reducing the incidence of these pathologies. In this sense, the objective of the work was to revalue second quality citrus fruits for the development of new beverages, rich in anthocyanins and flavanones (maqui berry and second qualities citrus-based), and evaluate the influence of alternative sweeteners (sucralose, sucrose, or stevia), regarding the bioaccessibility and bioavailability of these bioactive compounds in the frame of a chronic (longitudinal) intervention. To fulfill this objective, a longitudinal study of the urinary excretion of anthocyanins and flavanones, after 2-months of ingestion of the developed maqui-citrus beverage, by 138 volunteers (n = 46 per beverage) and the analysis of the resulting phenolic metabolites by ultra-high performance liquid chromatography coupled to mass spectrometry (UHPLC-ESI-QqQ-MS/MS) was carried out. As major results, the bioavailable metabolites of caffeic acid (CA), catechol (CAT), 3,4-di-hydroxyphenylacetic acid (DHPAA), eriodictyol (E), homoeriodictyol (HE), hippuric acid (HA), naringenin (N), trans-ferulic acid (TFA), 2,4,6-tri-hydroxybenzaldehyde (THBA), trans-isoferulic acid (TIFA), and vanillic acid (VA) were detected. Accordingly, significantly different bioavailability was dependent on the sweetener used, allowing proposing stevia and, to a lower extent, sucralose, as valuable alternatives to sucrose.

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Section: Resultsmentioning

confidence: 99%

Beverages Based on Second Quality Citrus Fruits and Maqui Berry, a Source of Bioactive (Poly)phenols: Sorting Out Urine Metabolites upon a Longitudinal Study

2021

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“…Furthermore, DPPE expressed antioxidant activity and defensive mechanisms by restoring oxidative stress/antioxidant balance in several toxic modules [ 40 , 49 , 93 ]. Many earlier studies of phytochemical or antioxidant elements have demonstrated their ability to reduce lipid peroxidation and improve the value of antioxidant markers in DOX cardiotoxicity [ 21 , 35 , 71 , 76 , 94 , 95 ]. The mechanism for protecting the DPPE may include de-activating potentially toxic metabolites and free radicals and potentiation of antioxidant paths [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

Date Palm Pollen Extract Avert Doxorubicin-Induced Cardiomyopathy Fibrosis and Associated Oxidative/Nitrosative Stress, Inflammatory Cascade, and Apoptosis-Targeting Bax/Bcl-2 and Caspase-3 Signaling Pathways

Elblehi

El‐Sayed

Soliman

et al. 2021

Animals

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Doxorubicin (DOX) has a potent antineoplastic efficacy and is considered a cornerstone of chemotherapy. However, it causes several dose-dependent cardiotoxic results, which has substantially restricted its clinical application. This study was intended to explore the potential ameliorative effect of date palm pollen ethanolic extract (DPPE) against DOX-induced cardiotoxicity and the mechanisms underlying it. Forty male Wistar albino rats were equally allocated into Control (CTR), DPPE (500 mg/kg bw for 4 weeks), DOX (2.5 mg/kg bw, intraperitoneally six times over 2 weeks), and DPPE + DOX-treated groups. Pre-coadministration of DPPE with DOX partially ameliorated DOX-induced cardiotoxicity as DPPE improved DOX-induced body and heart weight changes and mitigated the elevated cardiac injury markers activities of serum aminotransferases, lactate dehydrogenase, creatine kinase, and creatine kinase-cardiac type isoenzyme. Additionally, the concentration of serum cardiac troponin I (cTnI), troponin T (cTnT), N-terminal pro-brain natriuretic peptide (NT-pro BNP), and cytosolic calcium (Ca+2) were amplified. DPPE also alleviated nitrosative status (nitric oxide) in DOX-treated animals, lipid peroxidation and antioxidant molecules as glutathione content, and glutathione peroxidase, catalase, and superoxide dismutase activities and inflammatory markers levels; NF-κB p65, TNF-α, IL-1β, and IL-6. As well, it ameliorated the severity of histopathological lesions , histomorphometric alteration and improved the immune-staining of the pro-fibrotic (TGF-β1), pro-apoptotic (caspase-3 and Bax), and anti-apoptotic (Bcl-2) proteins in cardiac tissues. Collectively, pre-coadministration of DPPE partially mitigated DOX-induced cardiac injuries via its antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic potential.

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“…Previous studies have shown that proinflammatory cytokine expression, inflammatory cell infiltration and necrosis are commonly found in doxorubicin induced oxidative stress which ultimately lead to increased release of cardiac markers and natriuretic peptides to blood ( Ikegami et al, 2007 , Riad et al, 2009 ). A study done by Baniahmad et al (2020) showed that doxorubicin treatment increases cardiac biomarkers including cTnI, AST and LDH levels in rat serum while treatment with vanillic acid, a pharmaceutical compound which belongs to phenolic acid family significantly reduce the release of cardiac biomarkers indicating its cardioprotective activity based on antioxidant effect. Similar to these results ABEC which has high polyphenolic content and in vitro antioxidant effect also showed cardio protection against doxorubicin treatment by significantly reducing the release of cardiac biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…Doxorubicin induced cardiotoxicity was biochemically confirmed by the increase in oxidative stress as shown by the reduced antioxidant markers such as GSH, GPx, GR, SOD and catalase and total antioxidant capacity ( Baniahmad et al, 2020 ). Several previous investigations showed that doxorubicin treatment increases oxidative stress in rats and plant extracts or some other compounds with significant antioxidant activity have the ability to attenuate free radical induced oxidative stress indicating an increased activity of antioxidant markers ( Singh et al, 2008 , Al-Harthi et al, 2014 , Hamza et al, 2016 , Afsar et al, 2017 , Alam et al, 2018 , Shaker et al, 2018 , Li et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats

Sandamali

Hewawasam

Jayatilaka

et al. 2021

Saudi Pharmaceutical Journal

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Anti-tumour efficacy of doxorubicin is hindered by the cumulative dose-dependent cardiotoxicity induced by reactive oxygen species during its metabolism. As Cinnamomum zeylanicum has proven antioxidant potential, objective of this study was to investigate the cardioprotective activity of Cinnamomum bark extract against doxorubicin induced cardiotoxicity in Wistar rats. Physicochemical and phytochemical analysis was carried out and dose response effect and the cardioprotective activity of Cinnamomum were determined in vivo . 180 mg/kg dexrazoxane was used as the positive control. Plant extracts were free of heavy metals and toxic phytoconstituents. In vivo study carried out in Wistar rats revealed a significant increase (p < 0.05) in cardiac troponin I, NT-pro brain natriuretic peptide, AST and LDH concentrations in the doxorubicin control group (18 mg/kg) compared to the normal control. Rats pre-treated with the optimum dosage of Cinnmamomum (2.0 g/kg) showed a significant reduction (p < 0.05) in all above parameters compared to the doxorubicin control. A significant reduction was observed in the total antioxidant capacity, reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase activity while the lipid peroxidation and myeloperoxidase activity were significantly increased in the doxorubicin control group compared to the normal control (p < 0.05). Pre-treatment with Cinnamomum bark showed a significant decrease in lipid peroxidation, myeloperoxidase activity and significant increase in rest of the parameters compared to the doxorubicin control (p < 0.05). Histopathological analysis revealed a preserved appearance of the myocardium and lesser degree of cellular changes of necrosis in rats pre-treated with Cinnamomum extract. In conclusion, Cinnamomum bark extract has the potential to significantly reduce doxorubicin induced oxidative stress and inflammation in Wistar rats.

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Cardioprotective effect of vanillic acid against doxorubicin-induced cardiotoxicity in rat

Cited by 43 publications

References 35 publications

Beverages Based on Second Quality Citrus Fruits and Maqui Berry, a Source of Bioactive (Poly)phenols: Sorting Out Urine Metabolites upon a Longitudinal Study

Beverages Based on Second Quality Citrus Fruits and Maqui Berry, a Source of Bioactive (Poly)phenols: Sorting Out Urine Metabolites upon a Longitudinal Study

Date Palm Pollen Extract Avert Doxorubicin-Induced Cardiomyopathy Fibrosis and Associated Oxidative/Nitrosative Stress, Inflammatory Cascade, and Apoptosis-Targeting Bax/Bcl-2 and Caspase-3 Signaling Pathways

Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats

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