Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats

Fan, Sairong; Zhang, Junfeng; Xiao, Qi; Liu, Peng; Zhang, Yining; Yao, Enze; Chen, Xiaoming

doi:10.1016/j.ijbiomac.2020.01.068

Cited by 38 publications

(27 citation statements)

References 25 publications

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“…Only Ophiopogon polysaccharides, Lycium barbarum polysaccharides and Astragalus polysaccharides have been reported. Ophiopogon polysaccharides significantly reduce the levels of aminotransferase, lactate dehydrogenase, CK and CK-MB, increase ATPase activity, and exert protective effects on ischemia-induced myocardial injury 186 . The extract of Lycium barbarum promotes muscle differentiation and energy metabolism by upregulating mitochondrial biological gene regulatory factors 187 .…”

Section: Potential Drugs For Reducing Hf By Regulating Energy Metabolismmentioning

confidence: 97%

Energy metabolism disorders and potential therapeutic drugs in heart failure

Huang

Zhang

et al. 2021

Acta Pharmaceutica Sinica B

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Heart failure (HF) is a global public health problem with high morbidity and mortality. A large number of studies have shown that HF is caused by severe energy metabolism disorders, which result in an insufficient heart energy supply. This deficiency causes cardiac pump dysfunction and systemic energy metabolism failure, which determine the development of HF and recovery of heart. Current HF therapy acts by reducing heart rate and cardiac preload and afterload, treating the HF symptomatically or delaying development of the disease. Drugs aimed at cardiac energy metabolism have not yet been developed. In this review, we outline the main characteristics of cardiac energy metabolism in healthy hearts, changes in metabolism during HF, and related pathways and targets of energy metabolism. Finally, we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF.

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Section: Potential Drugs For Reducing Hf By Regulating Energy Metabolismmentioning

confidence: 97%

Energy metabolism disorders and potential therapeutic drugs in heart failure

Huang

Zhang

et al. 2021

Acta Pharmaceutica Sinica B

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“…Damaged in cardiac muscle induced by inadequate oxygen supply, become permeable and lead to leakage of cardiac enzymes that is, CK, CK‐MB, cTnT, and cTnI. The prolonged and magnitude of elevation is vital in evaluating the severity of infarction 17 . ISO‐induced cardiac damage showed increased serum cardiac markers indicating cardiac damage when compared to untreated groups (I and II).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of ferruginol on isoprenaline hydrochloride‐induced myocardial infarction in rats

Zhang

Wang

et al. 2020

Environmental Toxicology

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Cardiovascular‐related diseases continue to be a leading cause of death globally. Among ischemic‐induced cardiac diseases, myocardial infarction (MI) is reported to be of an alarming value. Despite numerous improvements in the medical intrusions, still this armamentarium fails to be effective in managing the illness without setbacks. Ferruginol (FGL) is a major polyphenols and terpenoids with numerous pharmacological activities including antioxidant and anti‐inflammatory. Following, this work was aimed to explore the cardio protective effect of FGL (50 mg/kg) in isoprenaline hydrochloride (ISO)‐induced MI in experimental rats. After treatment with FGL in ISO‐induced MI in rats, noticeable changes were observed in the experimental rats. Injection of ISO to rats resulted in the augmented cardiac weight, serum cardiac markers (creatine kinase, creatine kinase‐MB, cardiac troponin T, and Cardiac troponin I), lipid peroxidation end products (thiobarbituric acid‐reactive substance and lipid hydroperoxides), reduced endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione), reduced ATPase activity, and escalated pro‐inflammatory cytokines (interleukin‐6, tumor necrosis factor‐α, and nuclear factor‐κB) levels. Interestingly, the FGL supplementation to the ISO‐treated rats revealed the diminished heart weight, reduced cardiac markers, and lipid peroxidation. FGL also possessed the improved antioxidants status and diminished pro‐inflammatory mediator levels. The outcomes of histological analysis also evidenced the cardio protective role of FGL. Treatment with FGL reduced the cardiac damage biomarkers maintained to near normal levels in ISO‐induced rats. These study findings disclose the prospective capability of FGL in the treatment of MI in the future.

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“…A previous investigation indicated that polysaccharide from Ophiopogon japonici exerts protective effects against myocardial ischemia injury. 13 Diethyl blechnic, salvianolic acid B, cryptotanshinone, and tanshinone IIA extracted from Salvia Miltiorrhiza Bunge have been proven to prevent doxorubicin-induced cardiotoxicity both in vitro and in vivo. [14][15][16][17] The protective effects of YXC on doxorubicin-induced cardiotoxicity were initially and preliminarily demonstrated in the present in vitro study.…”

Section: Discussionmentioning

confidence: 99%

Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3β/β-catenin signaling

Ren

Cao

et al. 2020

J Int Med Res

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Background Yangxin granules (YXC), a Chinese herbal medicine, have been confirmed to have clinical benefits in the treatment of heart failure. This study examined the effects and molecular mechanisms of YXC in the treatment of doxorubicin-induced cardiotoxicity in vitro. Methods H9c2 cardiomyocytes were pretreated with YXC (5, 10, or 20 mg/mL) or the AKT inhibitor MK-2206 (50 nM) before doxorubicin treatment (1 µM). Cell apoptosis, viability, inflammatory factor expression (TNF-α, IL-1β, and IL-6), and oxidative stress mediator levels including superoxide dismutase, reactive oxygen species, and malondialdehyde were detected. Results YXC increased the viability of H9c2 cells. In addition, doxorubicin inhibited AKT/GSK3β/β-catenin signaling, whereas YXC increased the expression of phosphorylated AKT and GSK3β, and β-catenin in doxorubicin-treated H9c2 cells. Moreover, T-cell factor/lymphoid enhancer factor signaling downstream of β-catenin was also activated by YXC. YXC pretreatment also inhibited doxorubicin-induced inflammation, oxidative stress, and apoptosis. However, MK-2206 reversed the effects of YXC in doxorubicin-treated H9c2 cells. Conclusions YXC alleviates doxorubicin-induced inflammation, oxidative stress, and apoptosis in H9c2 cells. These effects might be mediated by the AKT/GSK3β/β-catenin signaling pathway. YXC might have preventive effects against doxorubicin-induced heart failure.

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Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats

Cited by 38 publications

References 25 publications

Energy metabolism disorders and potential therapeutic drugs in heart failure

Energy metabolism disorders and potential therapeutic drugs in heart failure

Ameliorative effect of ferruginol on isoprenaline hydrochloride‐induced myocardial infarction in rats

Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3β/β-catenin signaling

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