Cardioprotective effect of taurine and β-alanine against cardiac disease in myocardial ischemia and reperfusion-induced rats

Hou, Xiaolu; Sun, Guizhi; Guo, Ling; Gong, Zhaowei; Han, Ying; Xiu-juan, Bai

doi:10.1016/j.ejbt.2020.04.003

Cited by 12 publications

(11 citation statements)

References 39 publications

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“…In a previous study, as a result of ingesting 3.4 g of β-alanine and 3.4 g of arginine per day for 2 weeks to elite soldiers, it was shown that TNF-α and CRP significantly decreased in the intake group [42], a study showing that IL-6 decreased and IL-10 increased immediately after resistance exercise as a result of administering 2 g of L-carnosine and 2 g of β-alanine per day for 2 weeks to the general public [43] also showed a decrease in the levels of IL-6 and TNF-α immediately after exercise in the intake group, consistent with the results of previous studies. Animal data also showed that injection of β-alanine to mice induced by myocardial ischemia/reperfusion significantly reduced TNF-α and IL-6 [44], and the injection of glutamine and β-alanine to mice treated with resistance exercise showed TNF-α, IL-6, IL-1β decreased, and IL-10 increased [45] which is consistent with the results of this study.…”

Section: Discussionsupporting

confidence: 91%

Effects of 4 Weeks of Beta-Alanine Intake on Inflammatory Cytokines after 10 km Long Distance Running Exercise

Jin¹,

Moon²,

Kim³

et al. 2022

Exerc Sci

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PURPOSE: This study aimed to examine the immunological effects of β-alanine intake for 4 weeks on immune function changes after long-distance exercise and the possibility of β-alanine intake as an effective exercise supplement to improve exercise performance and maintain immune function.METHODS: Eighteen male college students were randomly assigned to two groups, one with two capsules of 250 mg β-alanine and the other with placebo without a nutritional effect. The participants took one capsule each in the morning and evening after the meals. This study was conducted in a double-blinded manner. To analyze the inflammatory cytokines expressed during exercise, a 10 km long-running exercise was performed, and blood was collected from the forearm vein a total of 4 times (at rest, immediately after exercise, 30 minutes, and 60 minutes in recovery).RESULTS: As a result of analyzing the level of inflammatory cytokine IL-6, compared to the placebo group, the β-alanine intake group decreased significantly to 60 minutes after recovery from long-distance aerobic exercise, and both groups showed a significant difference between both periods (<i>p</i><.001). However, there was no significant difference between the groups based on the measurement period before and after intake. As a result of analyzing the level of TNF-α, the expression of TNF-α in the placebo group was significantly decreased from immediately after long-distance aerobic exercise to 60 minutes after recovery, but in the β-alanine group, TNF-β expression did not occur immediately after exercise, and there was no significant difference until the recovery period; thus, there was no statistically significant difference between the two periods. In addition, there was no significant difference between the groups in terms of the measurement period before and after intake.CONCLUSIONS: Based on the above results, β-alanine intake for 4 weeks is thought to be effective in maintaining temporarily reduced immune function after long-distance exercise by reducing the level of inflammatory cytokines in the study participants.

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Section: Discussionsupporting

confidence: 91%

Effects of 4 Weeks of Beta-Alanine Intake on Inflammatory Cytokines after 10 km Long Distance Running Exercise

Jin¹,

Moon²,

Kim³

et al. 2022

Exerc Sci

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“…The importance of plasma taurine deficiency has mainly been demonstrated by taurine supplementation in animal models and clinical trials where it can prevent or mitigate various aspects of metabolic syndrome, including hyperglycemia, dyslipidemia, hypertension, oxidative stress, and inflammation [ 40 , 41 ]. In one study of cardiac disease in Wistar rats, a combined treatment of taurine and beta-alanine had dramatic effects on markers of oxidative stress and inflammation, increasing activity of glutathione peroxidase and superoxide dismutase by more than 175% and reducing serum levels of tumor necrosis factor (TNF)-α and interleukin-6 (IL-6) by nearly 60% [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of circulating metabolites associated with wooden breast and white striping

et al. 2022

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Current diagnostic methods for wooden breast and white striping, common breast muscle myopathies of modern commercial broiler chickens, rely on subjective examinations of the pectoralis major muscle, time-consuming microscopy, or expensive imaging technologies. Further research on these disorders would benefit from more quantitative and objective measures of disease severity that can be used in live birds. To this end, we utilized untargeted metabolomics alongside two statistical approaches to evaluate plasma metabolites associated with wooden breast and white striping in 250 male commercial broiler chickens. First, mixed linear modeling was employed to identify metabolites with a significant association with these muscle disorders and found 98 metabolites associated with wooden breast and 44 metabolites associated with white striping (q-value < 0.05). Second, a support vector machine was constructed using stepwise feature selection to determine the smallest subset of metabolites with the highest categorization accuracy for wooden breast. The final support vector machine achieved 94% accuracy using only 6 metabolites. The metabolite 3-methylhistidine, which is often used as an index of myofibrillar breakdown in skeletal muscle, was the top metabolite for both wooden breast and white striping in our mixed linear model and was also the metabolite with highest marginal prediction accuracy (82%) for wooden breast in our support vector machine. Overall, this study identified a candidate set of metabolites for an objective measure of wooden breast or white striping severity in live birds and expanded our understanding of these muscle disorders.

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“…Cultured neonatal rat cardiomyocytes exposed to ischemic conditions at varying time periods (24 to 72 h) with apoptosis showed the advantageous effects of taurine on the intrinsic apoptosis pathway [31,32]. Untreated cells exposed to ischemic conditions showed evidence of mitochondrial depolarization, cytochrome-c release, activation of the apoptotic pathway, and caspase-3 and caspase-9 expression [32,33]. In taurine-treated cells, there was no indication of attenuation in the mitochondrial membrane potential or a reduction in cytochrome-c release.…”

Section: Effects Of Taurine On the Cardiovascular Systemmentioning

confidence: 99%

“…Taurine displays cardioprotective abilities following cardiac injury [ 34 ]. Wistar rats that received orally administered taurine (100 mM) 30 days following coronary artery occlusion-induced ischemia had significantly smaller myocardial infarct size, elevated levels of superoxide dismutase, and decreased inflammatory markers of interleukin (IL)-6 and tumor necrosis factor alpha (TNF

), compared to controls [ 33 ]. This was suggestive that taurine supplementation may be an effective approach in cardio-protection.…”

Section: Effects Of Taurine On the Cardiovascular Systemmentioning

confidence: 99%

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

et al. 2020

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Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With its unique sulfonic acid makeup, taurine influences cellular functions, including osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids. Taurine exerts anti-inflammatory effects that improve diabetes and has shown benefits to the cardiovascular system, possibly by inhibition of the renin angiotensin system. The beneficial effects of taurine are reviewed.

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Cardioprotective effect of taurine and β-alanine against cardiac disease in myocardial ischemia and reperfusion-induced rats

Cited by 12 publications

References 39 publications

Effects of 4 Weeks of Beta-Alanine Intake on Inflammatory Cytokines after 10 km Long Distance Running Exercise

Effects of 4 Weeks of Beta-Alanine Intake on Inflammatory Cytokines after 10 km Long Distance Running Exercise

Identification of circulating metabolites associated with wooden breast and white striping

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

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