Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats

Farvin, K.H. Sabeena; Anandan, R.; Kumar, S Hari Senthil; Shiny, K S; Mathew, Suseela; Sankar, T.V.; Nair, P.G.V.

doi:10.1089/jmf.2006.9.531

Cited by 70 publications

(59 citation statements)

References 28 publications

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“…This is consistent with an earlier study (Farvin et al 2006) which also indicated that lipid peroxidation is a key factor in the pathogenesis of isoprenaline-induced myocardial infarction. The enhanced lipid peroxidation in heart lysosomes of isoprenaline-administered rats might have been due to the reduction in tissue antioxidant defense status, as reported earlier (Ganesan et al 2008b).…”

Section: Resultssupporting

confidence: 93%

Protective effect of betaine on changes in the levels of lysosomal enzyme activities in heart tissue in isoprenaline-induced myocardial infarction in Wistar rats

Ganesan

Anandan

2009

Cell Stress and Chaperones

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Myocardial infarction is one of the most common manifestations of cardiovascular disease. In the present study, we investigated the protective effect of betaine, a potent lipotropic molecule, on changes in the levels of lysosomal enzymes and lipid peroxidation in isoprenalineinduced myocardial infarction in Wistar rats, an animal model of myocardial infarction in man. Male albino Wistar rats were pretreated with betaine (250 mg/kg body weight) daily for a period of 30 days. After the treatment period, isoprenaline (11 mg/100 g body weight) was intraperitoneally administered to rats at intervals of 24 h for 2 days. The activities of lysosomal enzymes (β-glucuronidase, β-galactosidase, β-glucosidase, and acid phosphatase) were significantly (p<0.05) increased in plasma with a concomitant decline in the activities of these enzymes in heart tissue of isoprenaline-administered rats. Also, the level of lipid peroxidation was higher in heart lysosomes of isoprenaline-injected rats. Pretreatment with betaine daily for a period of 30 days to isoprenaline-induced rats prevented the changes in the activities of these lysosomal enzymes. Oral treatment with betaine (250 mg/kg body weight) to normal control rats did not show any significant effect in all the biochemical parameters studied. Thus, the results of our study show that betaine protects the lysosomal membrane against isoprenaline-induced myocardial infarction. The observed effects might be due to the free radical-scavenging and membrane-stabilizing properties of betaine.

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Section: Resultssupporting

confidence: 93%

Protective effect of betaine on changes in the levels of lysosomal enzyme activities in heart tissue in isoprenaline-induced myocardial infarction in Wistar rats

Ganesan

Anandan

2009

Cell Stress and Chaperones

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“…Cytotoxic enzymes such as CK-MB, LDH, AST, ALT and ALP, which serve as diagnostic markers, could be released from tissues damaged in the circulation due to permeable or disagreement of cell membrane and reflect the changes in plasma membrane integrity [27]. Our data confirmed significant increase in the levels of these enzymatic biomarkers of serum in ISO treated rats, which were in same direction with previous reports.…”

Section: Discussionsupporting

confidence: 92%

Cardio Protective Effects of Hydroalcholic Citrus Aurantium Extract on Myocardial Infarction Induced by Isoproterenol in Male Rats

2017

JCCR

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The citrus aurantium has traditionally been used by the people of Iran. The aim of this study was to evaluate the protective effects of hydroalcholic citrus aurantium extract on electrocardiographic, biochemical and pathological changes after myocardial infarction induced by isoproterenol in rats. 24 male Wistar rats were divided randomly into 4 groups: Control, extract, isoproterenol, and isoproterenol + pre-treatment with extract for two weeks. At the end of the experiment, ECG was recorded in lead II. Finally, blood samples were taken and cardiac marker enzymes such as creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, along with oxidative stress markers such as malondialdehyde, superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and lipid profile were determined.Myocardial infarction induced by isoproterenol produced a significant increase in the heart rate, ST-segment elevation, decrease in R amplitude, and a significant increase in the level of cardiac marker enzymes: LDH, CK-MB, AST, ALT and ALP in serum. Also, isoproterenol significantly reduced SOD, CAT, GSH, GP X and increased MDA activity, disturbance in lipid profile, and inflammatory process in cardiac myocytes. Pretreatment with citrus aurantium extract for two weeks significantly reduced the effect of isoproterenol on electrocardiographic parameters, cardiac biomarkers, oxidative stress indices, lipid profile and cardiac myocytes injuries.Results indicated that citrus aurantium extract ameliorates the cardio-toxic effects of isoproterenol through reinforcement of antioxidant defense system and may be of value in treatment of myocardial infarction. Further studies are required to determine the precise mechanism of the therapeutic effect of the extract.

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“…Some of them, eg linoleic acid, linolenic acid belong to exogenous acids that are crucial for human body [8,14]. They play an important role in hormone synthesis, build of cell membranes and regulation of their permeability [14,15]. Many valuable components are dissolved in the oil obtained from amaranthus seeds [8], such as squalene, tocopherols, and tocotrienols [7,8,14].…”

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confidence: 99%

“…Antioxidant properties of squalene are investigated by many scientists. The studies conducted on animals revealed that squalene is a protective factor against cardiac infarction which is caused by isoproteronol [15]. It is most probable that it is owing to squalene that the mechanism of blocking of induction of lipid peroxidation is triggered [15,16].…”

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confidence: 99%

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Assessment of Content of Fat and Tocopherols in Seeds of Amaranthus in Relation to Diversified Fertilization with Macroelements

Skwaryło-Bednarz¹

2012

Ecological Chemistry and Engineering S

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This study is based on the field experiment carried out in the years 2007-2008, on an individual farmer's field in Bodaczow, near Zamosc. The aim of the experiment was to determine the influence of different dosages of NPK on the content of fat and homologous tocopherols in the seeds of two varieties of amaranth: Rawa and Aztek. The experiment was started on brown soil made from loess, with high content of P, K and Mg, and slightly acidic reaction (pH in l mol KCl·dm -3 -5.8). The experiment was started with split-plot method in three repetitions, and involved: two varieties of amaranthus (Rawa and Aztek), and 4 variants of fertilization with macroelements NPK (kg · ha -1 ) (1 -object without any fertilization, 2 -70 N, 50 P2O5, 50 K2O; 3 -90 N, 60 P2O5, 60 K2O; 4 -130 N, 70 P2O5, 70 K2O). The content of fat was marked in the seed with Soxhlet's method, and α-, β-, γ-and δ-tocopherol with high performance liquid chromatography (HPLC). The study reveals that the amount of accumulated fat in the seeds of amaranthus largely depended on the variety of the plant and variant of fertilization with macroelements. Significantly high content of fat in the seeds was found at the fourth (the highest) level of fertilization with NPK. Higher content of fat in the seeds was determined in Aztec variety than Rawa. The varieties of amaranthus varied considerably in the content of: α-, β-tocopherol and their total amount. Higher content of α-tocopherol and its higher total amount was found in the seeds of Aztek variety, rather than Rawa. The seeds of Rawa variety had significantly more β-tocopherol than Aztek variety. Fertilization with growing dosages of NPK had a significant, positive influence only on the amount of α-tocopherol and its total amount.

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Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats

Cited by 70 publications

References 28 publications

Protective effect of betaine on changes in the levels of lysosomal enzyme activities in heart tissue in isoprenaline-induced myocardial infarction in Wistar rats

Protective effect of betaine on changes in the levels of lysosomal enzyme activities in heart tissue in isoprenaline-induced myocardial infarction in Wistar rats

Cardio Protective Effects of Hydroalcholic Citrus Aurantium Extract on Myocardial Infarction Induced by Isoproterenol in Male Rats

Assessment of Content of Fat and Tocopherols in Seeds of Amaranthus in Relation to Diversified Fertilization with Macroelements

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