Cardioprotective Effect of Resveratrol and Resveratroloside

Naumenko, S. E.; Латышева, Т В; Gilinsky, M. A.; Rogachev, Artem D.; Комарова, Н. И.; Salakhutdinov, N. F.; Толстиков, Г. А.

doi:10.2174/187152571103140120103302

Cited by 8 publications

(7 citation statements)

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“…Resveratrol, the main compound responsible for “French paradox,” was reported to have multiple health benefits though with some different opinions such as anticancer (Jang and others ), cardioprotective effect (Mokni and others ; Davies and Roulleau ; Naumenko and others ), antidiabetic effects (Szkudelska and Szkudelski ), and skin protection(Bastianetto and others ). Sample 2 (approximately 2.12 mg/g) had significantly higher content in resveratrol 3,5‐ O‐ β‐diglucoside than other species (1‐way ANOVA) and sample 12 had the lowest level of 0.31 mg/g, even though all tree peony seed showed higher content in resveratrol than red wine (approximately 2.9 mg/L).…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed

Mao

Han

Tian

et al. 2017

Journal of Food Science

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Eight wild species in Sect. Moutan DC (tree peony) of the genus Paeonia grown in natural habitats and 1 cultivated specie were investigated to analyze their fatty acid and bioactive phenolic compound profiles. For fatty acid composition, P. ludlowii contained the lowest α-linolenic acid (27.68%) and P. jishanensis contained the highest (51.96 %) content of the 9 species. For phenolic compounds, P. qiui contained the highest resveratrol (2.12 mg/g), P. delavayi contained the highest β-gentiobiosylpaeoniflorin (26.23 mg/g), and P. ostii contained the highest paeoniflorin (23.66 mg/g). P. ostii was selected to perform a feasibility study because of its relatively high level of α-linolenic acid 46.53%, low in ω-6 to ω-3 ratio of 1:2, and high level of the preferred bioactive phenolic compounds l including paeoniflorin and resveratrol. Physical pressing and refining process were conducted to obtain P. ostii seed oil. It exhibited bland sensory attributes described as slight grassy, very slight nutty, no painty or fishy aroma and slight grassy, slight nutty flavor with a very slight throat catch. Tocol results reported high level in tree peony seed oil 223.5 ± 13.65 mg/100 g with γ-tocopherol 70.1 ± 2.14 mg/100 g, and γ-tocotrienol 149.6 ± 15.83 mg/g. Because of the high total tocol, γ-tocopherol and γ-tocotrienol levels, and tree peony seed oil exhibited better oxidation stability than flaxseed oil even with similar α-linolenic acid levels. In addition, high levels of γ-tocopherol and γ-tocotrienol can introduce therapeutic effects such as antiinflammation and antioxidation. Therefore, this study showed that tree peony seed oil has a great potential to be used in edible oil, nutraceutical supplement, and other health care products.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed

Mao

Han

Tian

et al. 2017

Journal of Food Science

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“…Various investigations have exhibited that resveratrol could benefit T2DM treatment. This compound could enhance insulin sensitivity in patients with T2DM and diabetic rats, reduce blood glucose levels in animals, and protect the pancreatic cells. , Resveratroloside as a monoglucosylated form of resveratrol has been shown to possess antioxidant, antiaging, anti-inflammatory, and antimicrobial , activities and neuroprotective effects. , It has also been demonstrated to have more potent antiallergic and PDE inhibitory activities than those of the corresponding aglycone. , In addition, resveratroloside exhibited a higher cardioprotective effect compared to that of resveratrol . Up to now, studies on the antidiabetic activity of resveratroloside are lacking.…”

Section: Resultsmentioning

confidence: 99%

“…18,20 In addition, resveratroloside exhibited a higher cardioprotective effect compared to that of resveratrol. 31 Up to now, studies on the antidiabetic activity of resveratroloside are lacking.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting α-Glucosidase

Zhao

Tao

Zhang

et al. 2019

J. Agric. Food Chem.

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The regulation of postprandial blood glucose (PBG) levels is an effective therapeutic method to treat diabetes and prevent diabetes-related complications. Resveratroloside is a monoglucosylated form of stilbene that is present in red wine, grapes, and several traditional medicinal plants. In our study, the effect of resveratroloside on reducing PBG was studied in vitro and in vivo. In comparison to the starch treatment alone, the oral administration of resveratroloside−starch complexes significantly inhibited the PBG increase in a dose-dependent pattern in normal and diabetic mice. The PBG level treated with resveratrol (30 mg/kg) was not lower than that of resveratroloside. Further analyses demonstrated that resveratroloside strongly and effectively inhibited α-glucosidase, with an 50% inhibitory concentration value of 22.9 ± 0.17 μM, and its inhibition was significantly stronger than those of acarbose and resveratrol (264 ± 3.27 and 108 ± 2.13 μM). Moreover, a competitive inhibition mechanism of resveratroloside on α-glucosidase was determined by enzyme kinetic assays and molecular docking experiments. The molecular docking of resveratroloside with α-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of α-glucosidase. Resveratrol was also determined to be a competitive inhibition mechanism on α-glucosidase by enzyme kinetic assays and molecular docking experiments. This study suggested that resveratroloside had the ability to regulate PBG levels and can be considered a potential agent for the treatment of diabetes mellitus.

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“…The results indicated that Resveratroloside may greatly improve the area of myocardial infarction (MI) following 30 min of ischemia and 120 min of reperfusion, elucidating Resveratroloside's cardioprotective function (Naumenko et al, 2013).…”

Section: Resveratrolosidementioning

confidence: 99%

Stilbene‐based derivatives as potential inhibitors of trimethylamine (TMA)‐lyase affect gut microbiota in coronary heart disease

Huang

Wang-xing

et al. 2022

Food Science & Nutrition

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Coronary heart disease (CHD) is defined by atherosclerosis, which may result in stenosis or blockage of the arterial cavity, leading to ischemic cardiac diseases such as angina and myocardial infarction (MI). Accumulating evidence indicates that the gut microbiota play a critical role in the initiation and progression of CHD. The gut microbial metabolite trimethylamine N‐oxide (TMAO) is intimately linked to the pathophysiology of CHD. The hepatic flavin‐containing monooxygenases (FMOs) convert trimethylamine (TMA) to TMAO. As a result, it is critical to prevent TMA generation. Stilbenes could reduce cardiovascular disease mortality. Twelve stilbenes with inhibitory activity against TMA‐lyase were compiled and evaluated in this study. Docking results showed Resveratroloside had the highest Vina score, indicating that it was the most active and might be employed as a lead molecule for further structural modification.

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Cardioprotective Effect of Resveratrol and Resveratroloside

Cited by 8 publications

References 0 publications

Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed

Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed

Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting α-Glucosidase

Stilbene‐based derivatives as potential inhibitors of trimethylamine (TMA)‐lyase affect gut microbiota in coronary heart disease

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