Cardioprotective effect of prostacyclin and 7-oxo-PGI2 in rats against chronic isoproterenol damage

Körmöczy, P.Sz.; Vértesi, Cs.; Mikus, Endre G.; Tardos, L; Kovács, Gábor

doi:10.1016/0090-6980(87)90274-7

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…Сходный эффект на содержание тромбоксана при ЭБС оказывал D-Met 2 , Pro 5 -энкефалинамид [22]. Известно, что простациклин повышает устойчивость кардиомиоцитов к токсическому действию изопротеренола [30]. Следовательно, усиление синтеза простациклина, снижение продукции тромбоксана, а также подавление процессов ПОЛ могут иметь прямое отношение к механизму кардиопротекторного эффекта ОП у стрессированных животных.…”

Section: роль опиоидной системы в защите сердца от патогенного действunclassified

Endogenous Opioid System as a Mediator of Acute and Long-Term Adaptation to Stress. Prospects for Clinical Use of Opioid Peptides

et al. 2012

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It has been well established that opioid peptides (OPs) affect various hormonal systems. Opioids exhibit stress-limiting and gastro-protective effects in stressed animals, acting via μ- and δ-opioid receptors (OR). Peripheral μ-OR stimulation by endogenous and exogenous opioids increases cardiac tolerance to pathological consequences of stress. Enhancement of prostacyclin synthesis, decrease of thromboxane production as well as suppression of lipid peroxidation can be directly responsible for cardioprotective effects of OPs in stressed animals. Adaptive responses are accompanied by increased OP levels in blood and tissues. Reduction of ventricular arrhythmias induced by repeated short-term immobilization stress is mediated via μ-OR stimulation by endogenous opioids, while δ-OR account for an antiarrhythmic effect of adaptation to chronic intermittent hypobaric hypoxia. The mechanism of infarct size-limiting effect of continuous normobaric hypoxia involves both μ- and δ-OR stimulation. Peptide OR agonists can be considered in future clinical practice for treatment of withdrawal syndrome, stress-related cardiac disease or myocardial injury caused by ischemia-reperfusion insult.

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Section: роль опиоидной системы в защите сердца от патогенного действunclassified