Cardioprotective effect of Malva verticillata against doxorubicin -induced toxicity in rats

Abstract

Background M. verticillata (Malvaceae) is a medicinal plant used in the treatment of wounds, boils, and liver injuries. The plant leaf extracts possess anti-inflammatory and antioxidant activities. Doxorubicin (DOX) is a potent chemotherapeutic agent used in the treatment of various cancers, but its clinical use is limited by acute and chronic cardiotoxicity. This study aims to evaluate the possible cardioprotective role of Malva verticillata against doxorubicin-induced cardiotoxicity. Method Thirty-six male albino rats were divided into six groups, (n = 6): G1: normal control (was given 1 ml/kg of NaCl, 0.9%, twice a week IP), G2: cardiotoxic group (was given 1 mg/kg of DOX twice a week IP). G3 and G4 were given 250 mg/kg and 500 mg/kg of M. verticillata, respectively, while G5 and G6: were given 250, 500 mg/kg of M. verticillata PO and 1 mg/kg IP of DOX. for 6 weeks. Total body weight was taken weekly and Heart: body weight ratio was calculated. Blood samples were collected for determination of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and Troponin, the hearts were removed and processed for histopathological examination. Results M. verticillata showed a significant dose-dependent reduction in the cardiac enzyme levels, LDH, CPK activities, and Troponin levels. The histopathological studies in rat hearts also supported those findings. Conclusion The present study suggests that M. verticillata may have a novel and worthwhile cardioprotective effect against DOX-induced cardiotoxicity.

Bioactivity and antidiabetic properties of Malva parviflora L. leaves extract and its nano-formulation in streptozotocin-induced diabetic rats

“… Diabetic control (positive): STZ-induced Diabetic rats were fed a synthetic base diet. Group (1): STZ-induced diabetic rats fed a synthetic base diet plus an oral dose of Malva parviflora L. extract (500 mg/kg body weight/rat/day) ( Ibrahim et al., 2021 ). Group (2): STZ-induced diabetic rats fed a synthetic base diet plus an oral dose of Malva parviflora L. nano -formulation (500 mg/kg body weight/rat/day) ( Ibrahim et al., 2021 ).…”

“…Group (2): STZ-induced diabetic rats fed a synthetic base diet plus an oral dose of Malva parviflora L. nano -formulation (500 mg/kg body weight/rat/day) ( Ibrahim et al., 2021 ).…”

Natural Additives Improving Polyurethane Antimicrobial Activity

“…To heal diabetic wounds, PUR/carboxymethylcellulose nanofibers containing Malva sylvestris extract are used. Malva extract as a modifier was incorporated in the PUR and different amounts of carboxymethyl cellulose blend and has been observed utility, antibacterial, and wound healing properties [46][47][48][49][50]. The obtained research results indicated that increasing the diameter of the nanofibers and decreasing the carboxymethyl cellulose concentration raised in progressive the freeing time up to 85 h. The application of natural extract in the polymer material extended the mechanical and thermal properties of nanofibers.…”