Cardioprotective effect of influenza and pneumococcal vaccination in patients with cardiovascular diseases

Ciszewski, Andrzej

doi:10.1016/j.vaccine.2017.11.078

Cited by 41 publications

(38 citation statements)

References 25 publications

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“…Atherosclerosis is considered not only a disorder of lipid accumulation in the arterial wall but mainly an immune-mediated inflammatory disease, with both the innate and adaptive immune systems responding to various endogenous and exogenous antigens [16-18]. It is a chronic process with periods of acute destabilization and formation of vulnerable plaques leading to acute coronary syndrome (ACS).…”

Section: Coronary Heart Diseasementioning

confidence: 99%

“…Systemic factors as fever, dehydration, tachycardia, increased cardiac metabolic demands, hypoxemia and decreased blood pressure (i.e., in severe sepsis) may contribute to the development of myocardial ischaemia by diastole shortening, impaired myocardial perfusion through stenotic coronary segments, adrenergic surge, endothelial dysfunction and hypercoagulability [7, 18]. …”

Section: Coronary Heart Diseasementioning

confidence: 99%

“…The protective effect of vaccination is associated with the prevention of respiratory infections and the associated stresses [6, 18]. …”

Section: Potential Cardiovascular Protective Mechanisms Of Influenza mentioning

confidence: 99%

“…Furthermore, the cardioprotective effect of vaccination may be related to the modification of the immune-inflammatory model of atherosclerosis [18]. This specific mechanism based on studies that reported a protective effect of vaccination beyond the flu season, assumes specific immunogenic properties of the influenza virus and streptococcus pneumonia.…”

Section: Potential Cardiovascular Protective Mechanisms Of Influenza mentioning

confidence: 99%

“…This specific mechanism based on studies that reported a protective effect of vaccination beyond the flu season, assumes specific immunogenic properties of the influenza virus and streptococcus pneumonia. An ‘‘antigen mimicry” between the infectious agents and antigens of the atherosclerotic plaque has been proposed [7, 18]. Recently, the bradykinin 2 receptor was identified as a principal host protein that could mediate molecular processes underlying the cardioprotective effect of influenza vaccine [59].…”

Section: Potential Cardiovascular Protective Mechanisms Of Influenza mentioning

confidence: 99%

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Beneficial Effects of Vaccination on Cardiovascular Events: Myocardial Infarction, Stroke, Heart Failure

et al. 2018

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Influenza and pneumococcal infections have been suggested to be potential risk factors for causing adverse cardiovascular events, especially in high-risk patients. Vaccination against respiratory infections in patients with established cardiovascular disease (CVD) could serve as a potential cost-effective intervention to improve their clinical outcomes and cardiac societies have encouraged it. Previous studies have shown that influenza vaccination reduce mortality, acute coronary syndromes and hospitalization in patients with coronary heart disease (CHD) and/or heart failure (HF). However, there is a paucity of randomized prospective clinical trials in the field of the pneumococcal vaccination, and additional higher-quality evidence is needed. Furthermore, questions around the role of vaccination in the primary prevention of CVD, the optimal dose and timing are largely unanswered. The pathophysiologic mechanism in which vaccination provides cardiovascular protection may be related to the modification of the immune-inflammatory model of atherogenesis. The present review summarizes the current evidence and understanding for vaccination against influenza and streptococcus pneumoniae in CHD, HF and stroke and highlights its beneficial effect in the reduction of adverse cardiovascular events.

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Section: Coronary Heart Diseasementioning

confidence: 99%

Section: Coronary Heart Diseasementioning

confidence: 99%

“…The protective effect of vaccination is associated with the prevention of respiratory infections and the associated stresses [6, 18]. …”

Section: Potential Cardiovascular Protective Mechanisms Of Influenza mentioning

confidence: 99%

Section: Potential Cardiovascular Protective Mechanisms Of Influenza mentioning

confidence: 99%

Section: Potential Cardiovascular Protective Mechanisms Of Influenza mentioning

confidence: 99%

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Beneficial Effects of Vaccination on Cardiovascular Events: Myocardial Infarction, Stroke, Heart Failure

et al. 2018

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Obesity, Cardiovascular Disease, and Influenza: How Are They Connected?

Gutiérrez-Spillari

Aceituno-Melgar

2020

Curr Trop Med Rep

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Purpose of Review To better understand the impact of obesity and cardiovascular diseases on influenza A infection. Recent Findings This infection could have detrimental outcomes in obese patients with cardiovascular diseases, such as an increased risk, length of hospitalization, disease severity, morbidity, and mortality. Nevertheless, there also might be some cardioprotective benefits associated with influenza vaccination, such as a reduced mortality, hospitalization, and acute coronary syndromes, in patients with coronary heart disease and/or heart failure. Summary Obesity negatively impacts immune function and host defense. Recent studies report obesity to be an independent risk factor for increased morbidity and mortality following infection. Obese patients might need special considerations in the treatment; however, there is not enough evidence to fully comprehend the mechanisms behind the reduced immunocompetence when influenza A infection occurs. Future studies should focus on special consideration treatments when the patients have not been vaccinated and have cardiovascular diseases. Keywords Obesity . Influenza . Cardiovascular disease . Cardioprotective effects of vaccination . Influenza vaccine This article is part of the Topical Collection on Metabolism in Tropical Medicine

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Influenza Vaccination Blunts the Inflammatory Response in Patients Undergoing Cardiopulmonary Bypass

Atoui

Ebrahim

Saroka

et al. 2021

The Annals of Thoracic Surgery

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Cardioprotective effect of influenza and pneumococcal vaccination in patients with cardiovascular diseases

Cited by 41 publications

References 25 publications

Beneficial Effects of Vaccination on Cardiovascular Events: Myocardial Infarction, Stroke, Heart Failure

Beneficial Effects of Vaccination on Cardiovascular Events: Myocardial Infarction, Stroke, Heart Failure

Obesity, Cardiovascular Disease, and Influenza: How Are They Connected?

Influenza Vaccination Blunts the Inflammatory Response in Patients Undergoing Cardiopulmonary Bypass

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