Abstract:For today the exact mechanisms of myocardial infarction and ischemia/reperfusion injury are still not fully understood. ER stress and integrated stress response pathways are thought to play an essential role in myocardial damage. This includes activation of endoplasmic reticulum kinase PERK, induction of activating transcription factor ATF4, expression of pro-apoptotic transcription factor CHOP and P53 up-regulated modulator of apoptosis (PUMA) involved in apoptosis control. We used a rat model of isoprotereno… Show more
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