Cardioprotective effect of ellagic acid on doxorubicin induced cardiotoxicity in wistar rats

Warpe, Vikas S.; Mali, Vishal; Arulmozhi, S.; Bodhankar, Subhash L.; Mahadik, Kakasaheb R.

doi:10.1016/j.jacme.2015.02.003

Cited by 66 publications

(42 citation statements)

References 35 publications

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“…Left ventricular end diastolic pressure (EDP) and dP/dt max were significantly decreased in DOX-administered groups (II, III), at the end of the 3rd week; consistent with previous reports [Richard et al, 2011;Warpe et al, 2015;Razmaraii et al, 2016]. Fukuta and Little [2008] explained that by their observation that patients with dilated cardiomyopathy have a LV end-diastolic pressure-volume relationship that is shifted to the right.…”

Section: Discussionsupporting

confidence: 90%

“…No significant difference among the studied groups was reported in hemodynamic evaluation regarding systolic, diastolic, mean arterial blood pressures, and the heart rate (HR). Similar results were obtained by previous studies [Richard et al, 2011;Colak et al, 2012;Warpe et al, 2015]. ECG revealed significant prolongation of QT interval in DOX-administered groups (II, III) as reported by Rahimi_Balaei et al [2010]; Ashour et al [2011] and Warpe et al [2015]; denoting delayed repolarization and a negative chronotropic effect [Gandhi et al, 2013] or metabolic and electrolyte abnormalities associated with developed heart failure [Hunter et al, 2008].…”

Section: Discussionsupporting

confidence: 89%

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Functional and Structural Assessment of the Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells in Doxorubicin‐Induced Cardiotoxicity

Allah

Hussein

Hasan

et al. 2017

J of Cellular Biochemistry

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Cardiomyopathy induced by doxorubicin (DOX) was recognized at an early stage and also several years after drug administration. Mesenchymal stem cells (MSCs) have many properties that make them suitable for preventive and/or regenerative therapies. In this study, we evaluated the effect of MSCs in the functional and the structural improvement of DOX-induced cardiomyopathy in rats. Ninety adult male albino rats were randomly divided into three equal groups of thirty rats each: Group I (control): rats received normal saline. Group II (DOX- group): rats received DOX. Group III (DOX-MSCs group): rats received DOX for 2 weeks then human umbilical cord blood mesenchymal stem cells (hUCB-MSCs). Rats in all groups were evaluated for: physical condition, electrocardiography (ECG), and hemodynamic parameters. Serum cardiac troponin I (cTnI), malondialdehyde (MDA), total antioxidant capacity (TAC), and DNA fragmentation on heart tissue isolated DNA were estimated for evaluation of the mechanism and the extent of the damage. Hearts were examined histopathologically for detection of MSCs homing, structural evaluation, with counting of the collagen fibers for evaluation of fibrosis. DOX-administered rats showed significant functional and structural deterioration. DOX-MSCs treated rats (group III) showed improved functional and structural criteria with restoration of all biochemical indicators of cardiac damage and reactive oxygen species (ROS) to normal, as well. In Conclusion, hUCB-MSCs significantly ameliorated the cardiotoxic manifestations as shown by biochemical, functional, and structural cardiac improvement. J. Cell. Biochem. 118: 3119-3129, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Functional and Structural Assessment of the Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells in Doxorubicin‐Induced Cardiotoxicity

Allah

Hussein

Hasan

et al. 2017

J of Cellular Biochemistry

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“…Ellagic acid (E) is a naturally occurring phenolic compound found in grapes, nuts, strawberries, raspberries, green tea, pomegranates, as well as royal jelly and honey . Ellagic acid has received considerable attention because of its extensive array of biological properties including potent antioxidant, antiapoptotic, antiinflammatory, cardioprotective, ulcer healing, antifibrotic, antidiabetic, hypolipidemic, and antiatherosclerotic properties …”

Section: Introductionmentioning

confidence: 51%

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Georgy

Maher²

2017

J Biochem Mol Toxicol

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The anticancer drug doxorubicin causes testicular toxicity as an undesirable effect. The present study was undertaken to investigate the possible protection of ellagic acid and rosmarinic acid during doxorubicin administration. For this purpose eight groups of male Sprague-Dawley rats were used (n = 10), one group received vehicle served as control, and other groups received 5 mg/kg doxorubicin twice a week for 2 weeks for a cumulative dose of 20 mg/kg, ellagic acid (10 mg/kg/day, 14 consecutive days p.o.), rosmarinic acid (75 mg/kg/day, 14 consecutive days p.o.), ellagic acid and rosmarinic acid. The latter three regimens were given to control and doxorubicin-received rats. Doxorubicin decreased testicular relative weight, sperm count, motility, serum testosterone, testicular glycogen, and sialic acid with increased incidence of histopathological changes, oxidative stress, tumor necrosis factor-alpha, as well as cholinesterase activity. Conversely, ellagic and rosmarinic acid treatment ameliorated such damage, thus showing the possibility to use as an adjuvant during doxorubicin treatment.

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“…O. indicum Vent.root bark reportedly contains baicalein, chrysin, biochanin A and ellagic acid. Chrysin (Pushpavalli et al, 2010, Veerappan andSenthilkumar, 2015), biochanin-A (Zhang et al, 2011) and ellagic acid (Warpe et al, 2015a) are compounds attributed with anti-oxidant properties. There are proven studies of chemoprotective properties of ellagic acid (Rehman et al, 2012, Warpe et al, 2015b.…”

Section: Discussion:-mentioning

confidence: 99%

“…Chrysin (Pushpavalli et al, 2010, Veerappan andSenthilkumar, 2015), biochanin-A (Zhang et al, 2011) and ellagic acid (Warpe et al, 2015a) are compounds attributed with anti-oxidant properties. There are proven studies of chemoprotective properties of ellagic acid (Rehman et al, 2012, Warpe et al, 2015b. It is hence, conclusive that the presence of anti-oxidant compounds in the OIM extract may possibly have mediated the chemoprotective effects, through their combined action.…”

Section: Discussion:-mentioning

confidence: 99%

Chemoprotective Activity of Oroxylum Indicum Vent. Root Bark Against Cyclophosphamide Mediated Myelosuppression and Organ Injury.

Menon¹,

Lawrence²,

John³

et al. 2018

IJAR

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Cardioprotective effect of ellagic acid on doxorubicin induced cardiotoxicity in wistar rats

Cited by 66 publications

References 35 publications

Functional and Structural Assessment of the Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells in Doxorubicin‐Induced Cardiotoxicity

Functional and Structural Assessment of the Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells in Doxorubicin‐Induced Cardiotoxicity

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Chemoprotective Activity of Oroxylum Indicum Vent. Root Bark Against Cyclophosphamide Mediated Myelosuppression and Organ Injury.

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