Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection

Hernández, Matías; Wicz, Susana; Corral, Ricardo S.

doi:10.1016/j.phymed.2016.06.017

Cited by 28 publications

(24 citation statements)

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“… 10 In this context, recent reports from different research groups, including our own, have shown that the anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa , are beneficial to attenuate cardiac injury caused by this pathogen. 11 - 13 Current data further support the administration of Cur to improve vascular health. 14 Nevertheless, additional research is needed to determine the precise mechanisms involved in its therapeutic action against endothelial dysfunction.…”

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confidence: 81%

“…The dose was chosen based on previous oral studies of the anti-inflammatory effect of Cur in murine T. cruzi infection. 11 , 13 Another set of ten infected mice received oral therapy with Bz at 100 mg/kg body weight/day over the same period. 19 Bz (lot number 1614, purity ≥ 99% by high performance liquid chromatography), a reference standard drug against T. cruzi , was supplied by Laboratorio Elea, Buenos Aires, Argentina.…”

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confidence: 99%

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Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy

Hernández

Wicz

Santamaría³

et al. 2018

Mem. Inst. Oswaldo Cruz

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BACKGROUND The anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa, are increasingly considered to have beneficial effects on the progression of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi.OBJECTIVE To evaluate the effects of oral therapy with Cur on T. cruzi-mediated cardiovasculopathy in acutely infected mice and analyse the in vitro response of parasite-infected human microvascular endothelial cells treated with this phytochemical.METHODS Inflammation of heart vessels from Cur-treated and untreated infected mice were analysed by histology, with benznidazole (Bz) as the reference compound. Parasitaemia was monitored by the direct method. Capillary permeability was visualised by Evans-blue assay. Myocardial ET-1, IL-6, and TNF-α mRNA expressions were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Microvascular endothelial HMEC-1 cells were infected in vitro with or without addition of Cur or Bz. Induction of the Ca2+/NFAT pathway was assessed by fluorometry, immunoblotting, and reporter assay.FINDINGS Oral Cur therapy of recently infected mice reduced inflammatory cell infiltration of myocardial arteries without lowering parasite levels. Compared to that of the phosphate-buffered saline-receiving group, hearts from Cur-treated mice showed significantly decreased vessel inflammation scores (p < 0.001), vascular permeabilities (p < 0.001), and levels of IL-6/TNF-α (p < 0.01) and ET-1 (p < 0.05) mRNA. Moreover, Cur significantly (p < 0.05 for transcript; p < 0.01 for peptide) downregulated ET-1 secretion from infected HMEC-1 cells. Remarkably, Cur addition significantly (p < 0.05 at 27.0 μM) interfered with T. cruzi-dependent activation of the Ca2+/NFATc1 signalling pathway that promotes generation of inflammatory agents in HMEC-1 cells.CONCLUSIONS Oral treatment with Cur dampens cardiovasculopathy in acute Chagas mice. Cur impairs the Ca2+/NFATc1-regulated release of ET-1 from T. cruzi-infected vascular endothelium. These findings identify new perspectives for exploring the potential of Cur-based interventions to ameliorate Chagas heart disease.

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confidence: 81%

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confidence: 99%

Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy

Hernández

Wicz

Santamaría³

et al. 2018

Mem. Inst. Oswaldo Cruz

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“…Cardiovascular diseases (CVDs) have threatened human health severely worldwide. It has been documented that the intake of curcumin is beneficial to CVDs [ 153 , 154 ].…”

Section: Health Benefits Of Curcuminmentioning

confidence: 99%

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

et al. 2018

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Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.

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“…Recently, increasing evidence from preclinical studies has shown that Cu exerts myocardial protection, and is used in the treatment of cardiovascular diseases. Hernández et al has reported that Cu could play the cardioprotective actions on the pathogenic NFAT/COX‐2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection . Morover, Cu also has been reported to attenuate ischemia reperfusion injury by reducing ischemia reperfusion‐induced mitochondrial oxidative damage through the activation of SIRT1 signaling .…”

Section: Introductionmentioning

confidence: 99%

“…Hernández et al has reported that Cu could play the cardioprotective actions on the pathogenic NFAT/COX-2/ prostaglandin E2 pathway induced during Trypanosoma cruzi infection. 21 Morover, Cu also has been reported to attenuate ischemia reperfusion injury by reducing ischemia reperfusion-induced mitochondrial oxidative damage through the activation of SIRT1 signaling. 22 Furthermore, Sukardi et al found that Cu could process the cardioprotective effects via the inhibition of the c-Jun Nterminal kinase pathway and caspase-3 in cardiomyocytes, particularly in the ischemia phase.…”

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Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro

Yan

Zhou

et al. 2020

IUBMB Life

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The aim of this study was to investigate the protective effect of curcumin (Cu) on myocardial injury in diabetic cardiomyopathy in vivo and in vitro. Serum and myocardial glucose, inflammatory cytokines, and cardiac function indexes of type 2 diabetes db/db mice were measured. The mechanism of action was confirmed by immunohistochemistry, immunofluorescence, and western blot experiments. H9C2 cells stimulated by glucose (Glu) were used as cell models in vitro. Cu treatment improved glucose tolerance and lipid profile and reduced the production of inflammatory cytokines. In addition, Cu decreased the serum biochemical indexes. Cu inhibits high mobility group box 1 (HMGB1) signaling pathway in db/db mice. Cu treatment also significantly inhibited pa‐induced inflammatory signaling pathway in H9C2 cells. HMGB1 inhibitor or HMGB1 knockdown counteracted the effects of Cu on diabetic cardiomyopathy. The present study showed the protective effects of Cu on myocardial injury via HMGB1 pathway in diabetic cardiomyopathy in vivo and in vitro.

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Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection

Cited by 28 publications

References 28 publications

Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy

Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro

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