Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

Omar, Bassam; Gad, N M; Jordan, Maria C.; Striplin, S.; Russell, William J.; Downey, James M.; McCord, Joe M.

doi:10.1016/0891-5849(90)90123-z

Cited by 149 publications

(52 citation statements)

References 21 publications

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“…This fact suggests that 'gain of function' results in motor neuron degeneration in FALS. It has been reported, however, that a high level of SODl activity was sometimes toxic, as in the case of the reoxygenated heart [19] or mouse epidermal cells [20], as well as a low level of SODl activity [21]. On the other hand, SODl-deficient mice revealed no manifestations of motor neuron disease [22].…”

Section: Discussionmentioning

confidence: 97%

Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis

et al. 1997

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The mutant Cu/Zn Superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis (FALS) with a 2 bp deletion was produced in two protein expression systems. The mutant SOD1, expressed as a fusion protein in E. colt, had fanmunoreactivity to an anti-human SOD1 antibody but no SOD activity. It was more susceptible to proteolysis and its immunoreactivity decreased more rapidly than the wild type. The mutant SOD1, expressed in Cosl cells, was not detected by either SOD activity staining or Western blot analysis, although expression of its mRNA was confirmed. These results suggest that the mutant SOD1 is seriously unstable in mammalian cells.

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Section: Discussionmentioning

confidence: 97%

Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis

et al. 1997

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“…It is also suggests that the inhibitory effect of PC-SOD on cellular infiltration may be partially due to the life extendency of NO. On the other hand, the dose-response curve for PC-SOD showed a bell-shape pattern, like free SOD (13,14). SOD produces H2O2 in the process of scavenging 02.…”

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confidence: 99%

Effect of Lecithinized-Superoxide Dismutase on the Rat Colitis Model Induced by Dextran Sulfate Sodium.

et al. 1997

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ABSTRACT-Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu,Zn-SOD, has a longer half-life in blood and higher cell affinity than unmodified SOD. The effects of PC-SOD were evaluated using the rat ulcerative colitis model induced by 3% dextran sulfate sodium. Intravenous injection of rats with 0.5 or 1 mg/kg of PC-SOD suppressed the progression of bloody stools, the formation of erosion, and the infiltration of the colon with inflammatory cells. Furthermore, it also reduced the increase of leukocytes in blood. Thus, PC-SOD may have therapeutic potential in the treatment of ulcerative colitis.

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“…It is known that SOD and its mimetics including tempol exert pro-oxidative effects in high doses (10 -4 -10 -2 m) [15]. Inefficacy of higher tempol doses may be analogous to the previously described decrease of SOD cytoprotective activity at higher levels of the enzyme [16].…”

Section: Discussionmentioning

confidence: 74%

Age-dependent neuroprotection of retinal ganglion cells by tempol-C8 acyl ester in a rat NMDA toxicity model

Fiedorowicz

Ręjdak²,

Schuettauf³

et al. 2014

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Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

Cited by 149 publications

References 21 publications

Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis

Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis

Effect of Lecithinized-Superoxide Dismutase on the Rat Colitis Model Induced by Dextran Sulfate Sodium.

Age-dependent neuroprotection of retinal ganglion cells by tempol-C8 acyl ester in a rat NMDA toxicity model

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