Cardioprotection Afforded by Sour Cherry Seed Kernel

Czompa, Attila; Gyöngyösi, Alexandra; Czeglédi, András; Csepanyi, Evelin; Bak, István; Haines, David; Tósaki, Árpád; Lekli, István

doi:10.1097/fjc.0000000000000132

Cited by 29 publications

(37 citation statements)

References 30 publications

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“…Furthermore, as shown in Figure 2, ischemic-reperfusion injury-associated decreases in AF, CF, HR and CO, versus preischemic values, along with significantly increased recovery of AF and HR in animals fed the lyophilisate further supported the anti-ischemic properties of WGLL. These effects are consistent with previous studies by the authors, in which interventions that decrease oxidative stress on cardiac tissue dramatically improved recovery from ischemic events [31,32,33]. An interpretation of the significance of these outcomes to the cardioprotective ability of WGLL should be considered in the context of the fact that myocardial ischemic events typically reduce cardiac aortic blood pressure (AoP), along with a reduction in myocardial metabolic requirements, coronary blood flow and left ventricular tension.…”

Section: Discussionsupporting

confidence: 89%

Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits

Bombicz

Priksz

Varga

et al. 2016

IJMS

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The present investigation evaluates the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits. New Zealand rabbits were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks. At the zero- and eight-week time points, echocardiographic measurements were made, along with the determination of basic serum parameters. Following the treatment period, after ischemia-reperfusion injury, hemodynamic parameters were measured using an isolated working heart model. Western blot analyses of heart tissue followed for evaluating protein expression and histochemical study for the atheroma status determination. WGLL treatment mediated increases in fractional shortening; right ventricular function; peak systolic velocity; tricuspidal annular systolic velocity in live animals; along with improved aortic and coronary flow. Western blot analysis revealed WGLL-associated increases in HO-1 protein and decreases in SOD-1 protein production. WGLL-associated decreases were observed in aortic atherosclerotic plaque coverage, plasma ApoB and the activity of LDH and CK (creatine kinase) in plasma. Plasma LDL was also significantly reduced. The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders.

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Section: Discussionsupporting

confidence: 89%

Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits

Bombicz

Priksz

Varga

et al. 2016

IJMS

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“…Authors of this report have extensively characterized processes by which ischemia/reperfusion injury promotes infarction-associated tissue damage and methods by which it may be counteracted by increasing HO-1 expression. 30,31 Exploration by the authors, of mechanisms contributing to mechanisms by which infarcted zone expansion is augmented, strongly suggests that the antioxidant capacity of HO-1 reinforces compartmentalization of ionic species within cardiomyocytes and other cells composing cardiovascular tissue, the integrity of which is compromised by elevated levels of reactive oxygen molecules induced during the reoxygenation period associated with postischemic reperfusion. 32,33 …”

Section: Discussionmentioning

confidence: 99%

Alpha–Melanocyte-stimulating Hormone Induces Vasodilation and Exerts Cardioprotection Through the Heme-Oxygenase Pathway in Rat Hearts

Vecsernyés

Szokol

Bombicz

et al. 2017

Journal of Cardiovascular Pharmacology

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Abstract:Alpha–melanocyte-stimulating hormone (α-MSH) is a protein with known capacity for protection against cardiovascular ischemia–reperfusion (I/R) injury. This investigation evaluates the capacity of α-MSH to mitigate I/R effects in an isolated working rat heart model and determine the dependency of these alterations on the activity of heme oxygenase-1 (HO-1, hsp-32), a heat shock protein that functions as a major antioxidant defense molecule. Healthy male Sprague Dawley rats were used for all experiments. After treatment with selected doses of α-MSH, echocardiographic examinations were performed on live, anesthetized animals. Hearts were harvested from anesthetized rats pretreated with α-MSH and/or the HO-1 inhibitor SnPP, followed by cardiac function assessment on isolated working hearts, which were prepared using the Langendorff protocol. Induction of global ischemia was performed, followed by during reperfusion assessment of cardiac functions. Determination of incidence of cardiac arrhythmias was made by electrocardiogram. Major outcomes include echocardiographic data, suggesting that α-MSH has mild effects on systolic parameters, along with potent antiarrhythmic effects. Of particular significance was the specificity of dilatative effects on coronary vasculature, and similar outcomes of aortic ring experiments, which potentially allow different doses of the compound to be used to selectively target various portions of the vasculature for dilation.

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“…In addition, several studies revealed that cherry, Guangzao ( Choerospondias axillaris ), and acai ( Euterpe oleracea Mart.) have significant cardioprotective effects and have been shown to play a beneficial role in improving myocardial infarction induced by I/R via anti-oxidative and anti-apoptotic activities [88,89,90]. In addition, bilberry, black raspberry, and sea buckthorn berries improved serum lipid profiles and promoted a hypocholesterolemic effect, which protected against hypercholesterolemia and prevented atherosclerosis [91,92,93].…”

Section: Experimental Studiesmentioning

confidence: 99%

Fruits for Prevention and Treatment of Cardiovascular Diseases

et al. 2017

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Cardiovascular diseases (CVDs) are leading global health problems. Accumulating epidemiological studies have indicated that consuming fruits was inversely related to the risk of CVDs. Moreover, substantial experimental studies have supported the protective role of fruits against CVDs, and several fruits (grape, blueberry, pomegranate, apple, hawthorn, and avocado) have been widely studied and have shown potent cardiovascular protective action. Fruits can prevent CVDs or facilitate the restoration of morphology and functions of heart and vessels after injury. The involved mechanisms included protecting vascular endothelial function, regulating lipids metabolism, modulating blood pressure, inhibiting platelets function, alleviating ischemia/reperfusion injury, suppressing thrombosis, reducing oxidative stress, and attenuating inflammation. The present review summarizes recent discoveries about the effects of fruits on CVDs and discusses potential mechanisms of actions based on evidence from epidemiological, experimental, and clinical studies.

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Cardioprotection Afforded by Sour Cherry Seed Kernel

Cited by 29 publications

References 30 publications

Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits

Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits

Alpha–Melanocyte-stimulating Hormone Induces Vasodilation and Exerts Cardioprotection Through the Heme-Oxygenase Pathway in Rat Hearts

Fruits for Prevention and Treatment of Cardiovascular Diseases

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