Cardiomyoplasty: A Summing Up

Leirner, Adolfo A.

doi:10.1111/j.1525-1594.1995.tb02313.x

Artificial Organs

1995

DOI: 10.1111/j.1525-1594.1995.tb02313.x

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Cardiomyoplasty: A Summing Up

Adolfo A. Leirner¹

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Cited by 2 publications

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“…These reports comprise data from multicenter studies (2–5), from a worldwide database (Medtronic Dynamic Cardiomyoplasty Clinical Database, 1996), and from a randomized clinical trial (6,7). Nevertheless, several controversies remain about this surgical procedure, and since our optimistic publications in a special issue of this journal in 1995 (8,9) dynamic cardiomyoplasty clinical application has progressively decreased.…”

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Dynamic Cardiomyoplasty: A New Summing Up

Moreira

Leirner

2001

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confidence: 99%

Dynamic Cardiomyoplasty: A New Summing Up

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Leirner

2001

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Effects of Electrical Stimulation Postcardiomyoplasty in a Model of Chronic Heart Failure: Hemodynamic Results After Daily 12‐Hour Cessation Versus a Nonstop Regimen

Chekanov

Tchekanov

Rieder

et al. 2000

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The hemodynamic effects of cardiomyoplasty (CMP) have been investigated in many centers, but the question of whether it is necessary to stimulate the latissimus dorsi muscle (LDM) 24 hours a day has not been answered. The main goal of our investigation was to determine whether hemodynamic results after CMP were impaired when continuous electrical stimulation (ES) was off for 12 hours a day. A model of chronic heart failure was created in 12 sheep by performing an arteriovenous anastamosis and administering doxorubicin. Two weeks after the anastomosis, CMP was performed in eight sheep (experimental series); ES training was begun at 2 weeks after CMP. After completion of the initial ES conditioning (8 weeks after CMP), one group of sheep continued to receive ES 24 hours daily. Another group of sheep had only 12 hours of ES daily. Hemodynamic parameters were investigated 2 weeks later with the stimulator turned on and then off. With doxorubicin administration, arteriovenous anastamosis created a stable model of biventricular heart failure (right atrial pressure 20 +/- 3 mmHg vs 6 +/- 2 mmHg at baseline; pulmonary capillary wedge pressure 18 +/- 3 mmHg vs 9 +/- 2 mmHg; left ventricular end-diastolic area 15.2 +/- 1.2 cm2 vs 6.4 +/- 0.7 cm2; left ventricular ejection fraction 0.38 +/- 0.6 vs 0.65 +/- 0.7). Cardiomyoplasty improved hemodynamic status in all eight experimental sheep. However, when the investigation was performed with the stimulator off, this improvement was statistically insignificant. With stimulation on, there was decreased right atrial pressure, pulmonary capillary wedge pressure, left ventricular end-diastolic volume, and increased left ventricular ejection fraction. With the stimulator turned off for 12 hours daily, hemodynamic measurements did not differ from data with continuous ES for 24 hours daily. Because hemodynamic results do not seem to be impaired, we recommend daily, periodic cessation of stimulation to prevent damage to the LDM after CMP.

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Cardiomyoplasty: A Summing Up

Cited by 2 publications

References 13 publications

Dynamic Cardiomyoplasty: A New Summing Up

Dynamic Cardiomyoplasty: A New Summing Up

Effects of Electrical Stimulation Postcardiomyoplasty in a Model of Chronic Heart Failure: Hemodynamic Results After Daily 12‐Hour Cessation Versus a Nonstop Regimen

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