Cardiomyopathy and angiogenesis defects of Wistar rat fetuses of diabetic and hypercholesterolemic mothers

El‐Sayyad, Hassan I.; Al-Haggar, Mohamed S.; El-Ghawet, Heba A.; Bakr, Iman H.

doi:10.1016/j.nut.2011.12.013

Cited by 13 publications

(6 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar increase of myocardial lactate dehydraogenase was observed in old rats (Spindler et al, 1983) and in patients with heart failure (Hu et al, 2015). The observed increase of myocardial lactate dehydrogenase reflected exhausted myocardia damage during aging parallel to that observed by El-Sayyad et al (2012) in myocardium of hypercholesterolemic and diabetic rats. The observed increase of lactic dehydrogenase may lead to depletion of lactate as previously mentioned due to its characteristic function of catalyzes the interconversion of pyruvate and lactate via change of NADH and NAD + .…”

Section: Discussionsupporting

confidence: 60%

Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats

AL-Gebaly

2019

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Age-ing is involved in gradual breakdown of biological structure and function of body organs. The heart represents the main organ responsible for pumping the main issues of life which involving oxygen, nutrients and bioactive molecules necessary for maintaining the body functions. The present study has been conducted to assess the anti-aging properties of whey syrup collected from fermented milk in 4, 18 and 30-months-old rats. The histopathological and histochemical changes of carbohydrates and proteins were investigated. Immunohistochemical expression of smooth muscle actin and P53 was performed to assess the function of cardiomyocytes. Furthermore, Annexin v and biochemical changes of different cardio-biomarkers were carried out to evaluate the effects of aging. The present result of 30 months-old rats revealed myocardial infarction assessed by widening of myocardial fibers, diffused with numerous blood capillaries and dense leukocytic infiltration. The assessed biochemical markers confirmed myocardial damage. Whey supplementation improved the myocardial structure, but less improvement was observed for the 30-months-old rats. The author recommended supplementation with whey is beneficial in giving a body the demand for amino acids and minerals essential for supporting the myocardium and also provides protection against age-ing.

show abstract

Section: Discussionsupporting

confidence: 60%

Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats

AL-Gebaly

2019

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and the ability of the body to readily detoxify reactive intermediates or to repair the resulting damage (12). Numerous studies have demonstrated that oxidative stress is an important factor underlying abnormal cardiovascular system structure (13)(14)(15). In addition, various cardiovascular diseases, including hypertension, atherosclerosis, myocardial ischemia, ischemia-reperfusion injury, myocardial hypertrophy and heart failure, are associated with an increase in ROS generation.…”

Section: Introductionmentioning

confidence: 99%

The estrogen‑like protective effect of Lycium barbarum polysaccharides in reducing oxidative stress on myocardial cells from ovariectomized rats

Song

Liu

et al. 2019

Mol Med Report

View full text Add to dashboard Cite

Previous studies have demonstrated that ovariectomy may lead to a reduction in antioxidative biomarkers in the myocardium, thus suggesting that estrogens may serve a protective role in the suppression of oxidative stress. Lycium barbarum polysaccharides (LBP) are a well-known antioxidant Chinese traditional medicine, which appear to have a similar function to estrogens with regards to the regulation of cardiac function. In the present study, 30 Sprague-Dawley rats were randomly divided into the following groups: Sham operation group, ovariectomized (OVX) group, estradiol valerate group, high-dose LBP (LBP-H) group and low-dose LBP (LBP-L) group. All of the rats were provided tap water, estradiol valerate or LBP for 12 weeks. In addition, all rats were ovariectomized, with the exception of rats in the sham operation group, which underwent fat removal only. Reactive oxygen species (ROS), malondialdehyde (MDA), glutathione peroxidase (GSH-px), catalase (CAT) and superoxide dismutase activities were subsequently examined. The protein expression levels of cleaved caspase-9, cleaved caspase-3 and phosphorylated-protein kinase B (p-Akt) were also assessed. The results demonstrated that high-dose LBP decreased the enhanced levels of ROS and MDA in OVX rats, whereas GSH-px and CAT activities were increased in the LBP-H group compared with in OVX rats. Furthermore, the expression levels of cleaved caspase-9 and cleaved caspase-3 were significantly upregulated in the OVX group, whereas high-dose LBP exerted protective effects on OVX rats by decreasing the expression of apoptotic proteins. Conversely, p-Akt expression was decreased in the OVX group and was increased in the LBP-H group. These results indicated that LBP is essentially involved in cardiac protection by inhibiting apoptosis in response to oxidative stress. In addition, improvement of antioxidant status by LBP is associated with the Akt signaling pathway in the myocardium of OVX rats.

show abstract

“…During hypercholesterolemia, chylomicrons are hydrolysed into chylomicron-remnants (cholesterol rich particle, 100 and 1000 nm in size) which are picked up by the apo E receptors of the liver parenchyma especially M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 5 in the space of Disse through the fenestrated sinusoidal endothelium [38,39], they undergone de novo synthesis [40] and are involved in the pathogenesis of atherosclerosis. Diabetes and hypercholesterolemia have been associated with cardiovascular defects [41,42], with increase in levels of lipid biomarkers such as total cholesterol, HDL, low-density lipoprotein (LDL) and triglyceride and a decrease in high-density lipoprotein (HDL) [43,44]. Both diseases also developed a long term vascular complications, especially angiogenesis.…”

Section: Hypercholesterolemia and Ocular Diseasementioning

confidence: 99%

“…It is better to understand how to target the risk factors involved in hypercholesterolemic diet, in order to prevent the development of atherosclerosis, the marker of severe organ diseases as well as cardiovascular complications via elevated level of plasma OxLDL levels [1,2]. Oxidized LDL (10-200 μg/mL) augment the activity of acetylcholinesterase (AChE) after 24 h treatments and also increase the intracellular reactive oxygen formation causing cell damage [3].…”

Section: Introductionmentioning

confidence: 99%

Hypercholesterolemia-induced ocular disorder: Ameliorating role of phytotherapy

2015

Self Cite

View full text Add to dashboard Cite

Cardiomyopathy and angiogenesis defects of Wistar rat fetuses of diabetic and hypercholesterolemic mothers

Cited by 13 publications

References 60 publications

Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats

Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats

The estrogen‑like protective effect of Lycium barbarum polysaccharides in reducing oxidative stress on myocardial cells from ovariectomized rats

Hypercholesterolemia-induced ocular disorder: Ameliorating role of phytotherapy

Contact Info

Product

Resources

About