Cardiomyopathies

Braunwald, Eugene

doi:10.1161/circresaha.117.311812

Cited by 130 publications

(119 citation statements)

References 100 publications

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“…The elevated rate of suicide among individuals diagnosed with cardiomyopathy, which has not previously been documented, is disconcerting as this disease is known to affect individuals of all ages . Although the global number of deaths attributable to cardiomyopathy and myocarditis has decreased by 27% in recent decades , it is not clear whether also the suicide rate has decreased.…”

Section: Discussionmentioning

confidence: 97%

The association between heart diseases and suicide: a nationwide cohort study

et al. 2020

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Objective To assess the association between specific heart diseases and suicide. Design Nationwide retrospective cohort study. Participants A total of 7 298 002 individuals (3 640 632 males and 3 657 370 females) aged ≥15 years and living in Denmark during 1980–2016. Main outcome measures Incidence rate ratios (IRR) with 95% confidence intervals. In multivariate analysis, we adjust for sex, period, age group, living status, income level, Charlson Comorbidity Index, psychiatric disorders prior to heart disease and self‐harm prior to heart disease. Results Excess suicide rate ratios were found for following disorders: heart failure (IRR: 1.48; 95% CI: 1.38–1.58); cardiomyopathy (IRR: 1.41; 95% CI: 1.16–1.70); acute myocardial infarction (IRR: 1.28; 95% CI: 1.21–1.36); cardiac arrest with successful resuscitation (IRR: 4.75; 95% CI: 3.57–6.33); atrial fibrillation and flutter (IRR: 1.42; 95% CI: 1.32–1.52); angina pectoris (IRR: 1.19; 95% CI: 1.12–1.26); and ventricular tachycardia (IRR: 1.53; 95% CI: 1.20–1.94). A higher rate of suicide was noted during the first 6 months after the diagnosis of heart failure (IRR: 2.38; 95% CI: 2.04–2.79); acute myocardial infarction (IRR: 2.24; 95% CI: 1.89–2.66); atrial fibrillation and flutter (IRR: 2.70; 95% CI: 2.30–3.18); and angina pectoris (IRR: 1.83; 95% CI: 1.53–2.19) when compared to later. Conclusion Several specific disorders were found to be associated with elevated rates of suicide. Additionally, we found temporal associations with higher suicide rates in the first time after diagnosis. Our results underscore the importance of being attentive towards psychological distress in individuals with heart disease.

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Section: Discussionmentioning

confidence: 97%

The association between heart diseases and suicide: a nationwide cohort study

et al. 2020

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“…Heinz-Peter Schultheiss 1,2 *, DeLisa Fairweather 3 *, Alida L. P. Caforio 4 , Felicitas Escher 1,2,5 , Ray E. Hershberger 6 , Steven E. Lipshultz 7,8,9 , Peter P. Liu 10 , Akira Matsumori 11 , Andrea Mazzanti 12,13 , John McMurray 14 and Silvia G. Priori 12,13 Abstract | Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and impaired contraction that is not explained by abnormal loading conditions (for example, hypertension and valvular heart disease) or coronary artery disease. Mutations in several genes can cause DCM, including genes encoding structural components of the sarcomere and desmosome.…”

Section: Dilated Cardiomyopathymentioning

confidence: 99%

“…Ongoing advances in genetic sequencing and molecular methods are increasing the resources available to clinicians to determine the disease aetiology and provide a tailored risk stratification, resources which improve patient care and could potentially reverse disease progression. Further complicating the clinically heterogeneous presentation of DCM are differences that exist according to sex, age of onset (which can have an acute or progressive presentation), rate of progression, risk of development of overt heart failure and probability of sudden cardiac death 8,9 . Finally, both inherited predisposition and environmental factors play an important part in the natural history of disease.…”

mentioning

confidence: 99%

Dilated cardiomyopathy

Schultheiss

Fairweather

Caforio

et al. 2019

Nat Rev Dis Primers

441

381

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www.nature.com/nrdp P r i m e r 0123456789(); P r i m e r 0123456789(); 4 | Article citation ID: (2019) 5:32 www.nature.com/nrdp P r i m e r 0123456789(); P r i m e r 0123456789(); P r i m e r 0123456789(); 7 NATURE REVIEwS | DIsEAsE PRIMERs | Article citation ID: (2019) 5:32 P r i m e r 0123456789(); P r i m e r 0123456789(); 9 NATURE REVIEwS | DIsEAsE PRIMERs | Article citation ID: (2019) 5:32 P r i m e r 0123456789(); P r i m e r 0123456789(); P r i m e r 0123456789(); (2019) 5:32 www.nature.com/nrdp P r i m e r 0123456789(); P r i m e r 0123456789();

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“…Por otro lado, siempre se debe interrogar sobre la exposición a fármacos cardiotóxicos, quimioterápicos y radiación. Se debe realizar especial hincapié en lo que respecta a los diferentes síntomas del paciente, detallando la secuencia de presentación de los mismos, la asociación con fiebre, con dolores torácicos, articulares, etcétera (12,13) .…”

Section: Anamnesisunclassified

Miocardiopatía dilatada: ¿cuándo y cómo proceder a la investigación etiológica?

2018

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La miocardiopatía dilatada (MCD) es la forma más común de disfunción ventricular con una prevalencia en adultos de alrededor de 1/2.500 individuos. Durante muchos años la forma más descripta de MCD en los registros fue la idiopática. En los últimos diez años, los avances en las imágenes y la genética han permitido identificar formas específicas dentro de este grupo que llamábamos comúnmente idiopático. El estudio de los pacientes con MCD debe seguir los pasos habituales, comenzando con el trabajo clínico, evaluación de antecedentes personales y familiares, examen físico, y análisis profundo de electrocardiograma y ecocardiograma. La identificación de las características clínicas sugestivas de enfermedades específicas debería conducir a un trabajo de diagnóstico de segundo nivel que puede incluir análisis bioquímicos específicos, resonancia cardíaca, estudios anatomopatológicos y genéticos. A continuación repasamos estrategias para la mejor identificación de etiologías específicas.

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Cardiomyopathies

Cited by 130 publications

References 100 publications

The association between heart diseases and suicide: a nationwide cohort study

The association between heart diseases and suicide: a nationwide cohort study

Dilated cardiomyopathy

Miocardiopatía dilatada: ¿cuándo y cómo proceder a la investigación etiológica?

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