Cardiomyocyte ultrastructure in the perifocal zone of an experimental myocardial infarct in rats treated with the hexapeptide dalargin

Khlystov, V. V.; Усынин, А. Ф.; Pavlenko, V. S.; Slepushkin, V. D.

doi:10.1007/bf00835772

Bull Exp Biol Med

1988

DOI: 10.1007/bf00835772

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Cardiomyocyte ultrastructure in the perifocal zone of an experimental myocardial infarct in rats treated with the hexapeptide dalargin

V. V. Khlystov¹,

А. Ф. Усынин²,

V. S. Pavlenko³

et al.

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Cited by 2 publications

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“…However, subsequent course and outcome of the disease depend on what, specifically, developed in the myocardium -a necrotic focus or reversible dystrophy. Importantly, that in obvious myocardial infarction the area of macroscopically intact myocardium bordering the necrotic area is also subjected to morphological and ultrastructural changes to this or that measure [4]. Therefore, it is important to study the pathogenetic, defense, and adaptive mechanisms, developing in the course of acute disorders of coronary circulation in ischemic, but still viable myocardium.…”

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confidence: 97%

On some pathogenetic and adaptation mechanisms of acute coronary disease

2008

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Acute coronary failure was modeled in rabbits by ligation of the descending left coronary artery at the interface of its middle and lower thirds. The function and morphology of left-ventricular and right-ventricular myocardium were studied on days 1, 3, and 5 of the pathological process. It was found that left-ventricular contractility decreased, while right-ventricular contractility increased. Deep morphological changes were observed in both ventricles: pronounced extracellular edema, increased content of collagen, decreased percentage of myofibrils. Hence, acute coronary failure involves both compartments of the heart, but the adaptive mechanisms more actively develop in the right ventricle.

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confidence: 97%

On some pathogenetic and adaptation mechanisms of acute coronary disease

2008

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“…It was demonstrated that opioid peptides (OP) modify stress reaction [5], acting as a stress-limiting system factor. They produce a protective effect in myocardial ischemia [7]. These peptides modulate the release of neurotransmitters and conductivity of neuronal membrane [12], They also produce a wide range of biological effects on the digestive system.…”

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Opioid peptides modulate secretion of the basic determinants of bile secretion

Rudin

Medvedev

1997

Bull Exp Biol Med

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The effects of the synthetic opioid peptide dalargin and the antagonist of opiate receptors naloxone hydrochloride on the rate of bile secretion and concentration of bile acids and sodium ions is studied in rats. It is shown that the substances with opioid activity insignificantly raise the rate of bile secretion and concentration of the studied compounds. It is suggested that the secretion of the carbonate ion and glutathione increase under these conditions. Key Words: bile secretion, opioid peptides, dalargin, naloxoneThe role of endogenous opioid peptides (endorphins and enkephalins) in the regulation of physiological reactions and in modulation of pathological processes has been extensively investigated. It was demonstrated that opioid peptides (OP) modify stress reaction [5], acting as a stress-limiting system factor. They produce a protective effect in myocardial ischemia [7]. These peptides modulate the release of neurotransmitters and conductivity of neuronal membrane [12], They also produce a wide range of biological effects on the digestive system. For instance, g-and 5-agonists modify the amount and composition of pancreatic juice and limit pathological process in acute pancreatitis [1]. Synthetic OP analogs exhibit antiulcer [6] and hepatoprotective [2] activities. However, there is no data on the effect of OP and their synthetic analogs on secretory function of the liver. A close anatomic and functional relationship between the organs of the proximal alimentary canal and detection of binding sites for the substances with opioid activity in the liver [4] strongly suggests that OP play a role in the regulation of secretory function of the liver. Based on the finding that dalargin stimulates bile secretion, we decided to examine the effect of dalargin on the major determinants of bile secretion [10].

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Cardiomyocyte ultrastructure in the perifocal zone of an experimental myocardial infarct in rats treated with the hexapeptide dalargin

Cited by 2 publications

References 1 publication

On some pathogenetic and adaptation mechanisms of acute coronary disease

On some pathogenetic and adaptation mechanisms of acute coronary disease

Opioid peptides modulate secretion of the basic determinants of bile secretion

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