Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis

“…(Plin5-Tg) provokes cardiac TG accumulation, which was compatible with normal heart function ( 20,26 ). FGF21 mRNA levels were also increased (3.3-fold) in CM of Plin5-Tg mice (supplementary Fig.…”

Fatty acids regulate perilipin5 in muscle by activating PPARδ

“…Although it is unclear how interactions between perilipin5 and the above mentioned proteins regulate lipolysis, accumulating evidence from mice demonstrate that perilipin5 preserves LDs. Perilipin5-null mice lack LDs in the heart ( 30 ) whereas cardiacspecifi c perilipin5 transgenic mice accumulate LDs ( 74,75 ). Alteration in cardiac perilipin5 primarily affects TAG storage, which would be expected based on the preferred binding of perilipin5 to LDs fi lled with TAG ( 47 ).…”

Perilipin 5: putting the brakes on lipolysis

“…The physical nature of the linking mechanism is as yet unknown, as are the consequences of the linkage. Importantly, Wang et al ( 4 ) reveal that perilipin 5 overexpression impairs mitochondrial function, reducing the function of mitochondrial enzymes, and altering mitochondrial respiration, despite increases in mitochondrial size. The functional signifi cance of the link between perilipin 5, lipid droplets, and mitochondria requires further study.…”