“…The physical nature of the linking mechanism is as yet unknown, as are the consequences of the linkage. Importantly, Wang et al ( 4 ) reveal that perilipin 5 overexpression impairs mitochondrial function, reducing the function of mitochondrial enzymes, and altering mitochondrial respiration, despite increases in mitochondrial size. The functional signifi cance of the link between perilipin 5, lipid droplets, and mitochondria requires further study.…”