Cardiometabolic Risk, Inflammation, and Neurodegenerative Disorders

Palavra, Filipe; Diaz, Ethel Ciampi; Sena, Armando

doi:10.1007/978-3-319-16018-4_7

Cited by 2 publications

(3 citation statements)

References 118 publications

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“…39,50 Attributing causative properties and independent risk predictive capabilities, though yet to be established, could be of great value since LGI is known for both being easily detected by standard and simple assays as well as intervention responsive (eg, medical or lifestyle modifications). 150 While the former justifies its clinical utility, 157,158 the latter emphasizes its importance as a possible target for disease prevention. 159…”

Section: Long-covid Pain Symptoms Inflammatory Correlatesmentioning

confidence: 99%

Consistency of inconsistency in long‐COVID‐19 pain symptoms persistency: A systematic review and meta‐analysis

Kerzhner,

Berla,

Har‐Even

et al. 2023

Pain Practice

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IntroductionIndividuals recovering from acute COVID‐19 episodes may continue to suffer from various ongoing symptoms, collectively referred to as Long‐COVID. Long‐term pain symptoms are amongst the most common and clinically significant symptoms to be reported for this post‐COVID‐19 syndrome.ObjectivesThis systematic review and meta‐analysis aimed to evaluate the proportions of persisting pain symptoms experienced by individuals past the acute phase of COVID‐19 and to identify their associated functional consequences and inflammatory correlates.MethodsTwo online databases were systematically searched from their inception until 31 March 2022. We searched primary research articles in English, which evaluated individuals after laboratory‐confirmed COVID‐19 acute phase resolution and specifically reported on pain symptoms and their inflammatory and/or functional outcomes.ResultsOf the 611 identified articles, 26 were included, used for data extraction, and assessed for their methodological quality and risk of bias by two independent reviewers. Pain symptoms were grouped under one of six major pain domains, serving as our primary co‐outcomes. Proportional meta‐analyses of pooled logit‐transformed values of single proportions were performed using the random‐effects‐restricted maximum‐likelihood model. An estimated 8%, 6%, 18%, 18%, 17%, and 12% of individuals continued to report the persistence of chest, gastrointestinal, musculoskeletal joint, musculoskeletal muscle, general body, and nervous system‐related pain symptoms, respectively, for up to one year after acute phase resolution of COVID‐19. Considerable levels of heterogeneity were demonstrated across all results. Functional and quality‐of‐life impairments and some inflammatory biomarker elevations were associated with the persistence of long‐COVID pain symptoms.ConclusionThis study's findings suggest that although not well characterized, long‐COVID pain symptoms are being experienced by non‐negligible proportions of those recovering from acute COVID‐19 episodes, thus highlighting the importance of future research efforts to focus on this aspect.

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Section: Long-covid Pain Symptoms Inflammatory Correlatesmentioning

confidence: 99%

Consistency of inconsistency in long‐COVID‐19 pain symptoms persistency: A systematic review and meta‐analysis

Kerzhner,

Berla,

Har‐Even

et al. 2023

Pain Practice

View full text Add to dashboard Cite

show abstract

“…The hypothalamus, an extremely relevant vegetative centre, has been strongly implicated in all those circuits and, in recent years, hypothalamic inflammation has emerged as an important driver of energy homeostasis dysfunction, disrupting normal action of metabolic signals that support the balance between anabolism and catabolism . This small set of grey matter nuclei, located under the thalamus, has been proving to be a keystone across the pathophysiology of obesity and a connecting element between systemic metabolic inflammation and CNS dysfunction . But a logical question that arises at this stage is whether overnutrition has the ability to induce brain structural and functional changes.…”

Section: Overnutrition Chronic Inflammation and Brain Dysfunction: Amentioning

confidence: 99%

“…It is critical to note that inflammatory signalling in the hypothalamus of both mice and rats can be detected as early as 1–3 d after initiation of high‐fat diet and that reactive gliosis and neuronal injury become apparent during the first week, which is clearly prior to weight gain (this contrasts with inflammation in peripheral tissues, whose development is dependent on the obesity itself) . These changes can be reversed in a very early phase if high‐fat diet is interrupted, but with continued consumption of fat excess they become permanent, particularly at the mediobasal hypothalamus.…”

Section: Overnutrition Chronic Inflammation and Brain Dysfunction: Amentioning

confidence: 99%

Obesity and brain inflammation: a focus on multiple sclerosis

et al. 2016

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The increase in prevalence of obesity in industrialized societies is an indisputable fact. However, the apparent passive role played by adipocytes, in pathophysiological terms, has been gradually substituted by a metabolically active performance, relevant to many biochemical mechanisms that may contribute to a chronic low-grade inflammatory status, which increasingly imposes itself as a key feature of obesity. This chronic inflammatory status will have to be integrated into the complex equation of many diseases in which inflammation plays a crucial role. Multiple sclerosis (MS) is a chronic inflammatory condition typically confined to the central nervous system, and many work has been produced to find possible points of contact between the biology of this immune-mediated disease and obesity. So far, clinical data are not conclusive, but many biochemical features have been recently disclosed. Brain inflammation has been implicated in some of the mechanisms that lead to obesity, which has also been recognized as an important player in inducing some degree of immune dysfunction. In this review, we collected evidence that allows establishing bridges between obesity and MS. After considering epidemiological controversies, we will focus on possible shared mechanisms, as well as on the potential contributions that disease-modifying drugs may have on this apparent relationship of mutual interference.

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Cardiometabolic Risk, Inflammation, and Neurodegenerative Disorders

Cited by 2 publications

References 118 publications

Consistency of inconsistency in long‐COVID‐19 pain symptoms persistency: A systematic review and meta‐analysis

Consistency of inconsistency in long‐COVID‐19 pain symptoms persistency: A systematic review and meta‐analysis

Obesity and brain inflammation: a focus on multiple sclerosis

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