Cardiometabolic Risk in Hyperlipidemic Men and Women

Abstract

Objective. The aim of this study was to evaluate sex specific differences of metabolic and clinical characteristics of treated hyperlipidemic men and women (HL-men and HL-women). Methods. In this study vascular and metabolic characteristics of 35 HL-women and 64 HL-men were assessed. In addition a sex specific analysis of metabolic and nutritional habits of HL-patients with prediabetes (HL-IGR) was done. Results. HL-women were older and had favourable concentrations of high density lipoprotein cholesterol (HDL-cholesterol), triglycerides (TG), and triglyceride/HDL-cholesterol ratio (TG/HDL-ratio) but were also shown to have higher concentrations of lipoprotein-a compared to HL-men. HL-men were characterized as having higher levels of liver-specific parameters and body weight as well as being more physically active compared to HL-women. Brain natriuretic peptide (pro-BNP) was higher in HL-women than HL-men, while no differences in metabolic syndrome and glycemic parameters were shown. HL-IGR-women were also older and still had a better profile of sex specific lipid parameters, as well as a lower body weight compared to HL-IGR-men. No differences were seen in vascular parameters such as the intima media thickness (IMT). Conclusion. HL-women were older and had overall more favourable concentrations of lipid parameters and liver enzymes but did not differ regarding vascular morphology and insulin sensitivity compared to HL-men of comparable body mass index (BMI).

Sonographic Assessment of Intima-Media Thickness of Carotid Arteries - A Review of Literature

“…23 Michael Leutner et al showed in their study that there was no significant difference in carotid IMT measurements between Hyperlipidemic men and Hyperlipidemic women. 24 In current study we found that stroke is associated with increased IMT. Similar to this study Peiyang Zhou et al stated that there is a link between IMT and the risk of stroke in young people.…”

The Cardiac Lipidome in Models of Cardiovascular Disease

“…Obesity is a growing epidemic and patients characterized as obese are at risk for developing cardiovascular complications that could be linked to 3.4 million deaths worldwide in 2010 [21]. High fat and high cholesterol diets found in Western countries contribute to the development of cardiovascular risk factors such as hyperlipidemia and hypercholesterolemia [8]. High levels of these circulating lipids can lead to the accumulation of lipid plaques in arterial walls, which are also known as atherosclerosis [22].…”

“…Therefore, lipids have a direct role in cardiovascular function. On the other hand, regarding lipid excess experienced when diets high in fat are consumed, hyperlipidemia and hypercholesterolemia can result, which puts patients at risk for developing atherosclerosis and cardiometabolic disease [7,8].…”

The Genetic Architecture of the Clustering of Cardiometabolic Risk Factors: A Study of 8- to 17-Year-Old Chinese Twins

“…Epidemiologic studies have found that men have a higher risk of cardiovascular mortality compared to women and have a higher risk of developing CVD at earlier onset (Leutner et al, 2016). Previous twin studies on common CVD risk factors have also established that genetic and environmental factors contributing to them often differ by sex, age, and ethnicity (Li et al, 2016;Liao et al, 2017;Poveda et al, 2017;Song et al, 2015;Tanaka et al, 2015).…”