Cardiometabolic Risk in Chinese Women with Prior Gestational Diabetes: A 15-Year Follow-Up Study

Tam, Wing Hung; Ma, Rong; Yang, Xilin; Ko, G. T. C.; Lao, Terence T.; Chan, Michael; Lam, Christopher Wai‐Kei; Cockram, Clive S.; Chan, Juliana C.N.

doi:10.1159/000329339

Cited by 26 publications

(22 citation statements)

References 101 publications

(57 reference statements)

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“…In the long term, the mother is at high risk for type 2 DM, and 70% of these patients are afflicted within 25 years postpartum [13]. Women with a history of GDM also have an increased incidence of cardiovascular disease [14,15]. …”

Section: Discussionmentioning

confidence: 99%

Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Taşdemir¹,

Taşdemir²,

Kılıç³

et al. 2014

Gynecol Obstet Invest

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Background/Aims: The aim of this prospective study was to determine ionized and total magnesium (Mg) levels in pregnant subjects with and without gestational diabetes mellitus (GDM). Methods: Eighty-five women, 26-28 weeks pregnant, were recruited for routine oral glucose tolerance tests (OGTT); 45 had normal OGTT results and 40 were diagnosed with GDM. Electrolyte levels, including ionized and total Mg, were analyzed. Results: Gestational age and BMI were similar between the two groups (p = 0.800, p = 0.025). Multivitamin use was higher in the control group (p = 0.036). Fasting blood glucose was higher in the GDM group (p < 0.001). The median total Mg levels were 1.9 mg/dl (range 1.6-2.2) in the control group and 1.8 mg/dl (range 1.2-2.1) in the GDM group (p < 0.001). The median ionized Mg levels were 0.5 mmol/l (range 0.4-0.6) in the control group and 0.4 mmol/l (range 0.4-0.5) in the GDM group (p < 0.001). Conclusion: Our study revealed a relationship between low total and ionized Mg levels and GDM, as in type 2 diabetes mellitus (DM). The literature regarding type 2 DM and our findings suggest that Mg is the key ion in the pathophysiology of GDM. Low-dose Mg supplementation was not related to GDM; however, pharmacological doses in the various stages of pregnancy could be beneficial and should be investigated.

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Section: Discussionmentioning

confidence: 99%

Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Taşdemir¹,

Taşdemir²,

Kılıç³

et al. 2014

Gynecol Obstet Invest

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“…GDM affects 5-10% of Asian women, a trend that is increasing in some developing countries [2], with a higher reported frequency during the last decade [3,4]. GDM, one of the most common metabolic disorders of pregnancy, is often associated with maternal and fetal complications [5]. Recent years have seen a growing interest in the genetic basis of GDM and its manifestations.…”

Section: Introductionmentioning

confidence: 99%

Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women

Li¹,

Qiao

Zhan³

et al. 2013

Gynecol Obstet Invest

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Background/Aims: The purpose of this study was to investigate the association between MTNR1A and MTNR1B gene polymorphisms and gestational diabetes mellitus (GDM) in Han Chinese women. Methods: Study participants included 350 patients with GDM and 480 control subjects. Three single-nucleotide polymorphisms (SNPs; rs2119882 in MTNR1A and rs10830963 and rs10830962 in MTNR1B) were genotyped using direct sequencing. Genotype and allele distributions of SNPs in cases of GDM and controls were analyzed. Association of the MTNR1A and MTNR1B gene variants with plasma glucose and insulin levels as well as blood lipid levels was further investigated. Results: The frequencies of genotypes and allele types of rs2119882 in MTNR1A and rs10830963 in MTNR1B were significantly different between women with GDM and controls (p < 0.05). Moreover, in the GDM group, these SNPs were associated with increased fasting plasma glucose concentrations (p < 0.001) and increased homeostasis model assessment of insulin resistance (p < 0.001). The rs10830962 polymorphism in MTNR1B was not associated with an increased risk of developing GDM or any of the clinical or metabolic characteristics in patients with GDM (p > 0.05). Conclusion: The genetic polymorphisms rs2119882 in MTNR1A and rs10830963 in MTNR1B are associated with an increased risk of developing GDM and insulin resistance in Han Chinese women.

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“…This is also the case for diabetes in pregnancy -gestational diabetes mellitus (GDM) (1,2). The association between GDM and adverse pregnancy outcomes is well documented (3,4,5,6). The linear association between increasing maternal blood glucose levels and adverse pregnancy outcomes has raised the question of which criteria should be used for GDM diagnosis (7).…”

Section: Introductionmentioning

confidence: 99%

Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria

Helseth

Salvesen

Carlsen

2013

European Journal of Endocrinology

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Objective: The consequences of the recently proposed International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria for gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS) are not known. We compared the prevalence rates and risk factors for GDM in PCOS women according to both the WHO and the modified IADPSG criteria. Design: Post hoc analyses from a randomized, multicenter study were used. Methods: Fasting and 2-h plasma glucose levels were measured using a 75 g oral glucose tolerance test. GDM was diagnosed according to both the WHO and the modified IADPSG criteria.Results: The prevalence rates of GDM according to the WHO and the modified IADPSG criteria were 9.2 and 15.0% at week 12, 18.7 and 18.7% at week 19, and 25.6 and 24.2% at week 32. Shorter stature and increased insulin levels were correlated with WHO-GDM, but not with modified IADPSG-GDM at weeks 12 and 19. Less weight gain in pregnancy predicted GDM according to both sets of criteria. GDM diagnosis was correlated with less maternal weight loss the first year post-partum. Conclusions: No difference was found in the prevalence of GDM between the two sets of criteria used. Less weight gain in pregnancy was associated with GDM, independent of the diagnostic criteria used. Reduced weight loss the first year post-partum in women with GDM raises the question of whether GDM diagnosis per se or the fact that these women lose less weight after pregnancy predicts later diabetes mellitus.

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Cardiometabolic Risk in Chinese Women with Prior Gestational Diabetes: A 15-Year Follow-Up Study

Cited by 26 publications

References 101 publications

Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women

Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria

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