Cardiometabolic Health Among Cancer Survivors: A 13-Week Pilot Study of a Combined Aerobic and Resistance Training Program

Grote, Silvie; Almstedt, Hawley C.; Tarleton, Heather P.

doi:10.1188/16.onf.306-315

Cited by 7 publications

(9 citation statements)

References 57 publications

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“…Survivor studies with information on altered biomarker values but no direct comparison between biomarker and MetS occurrence were excluded. 60 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 We expected to miss many relevant studies when designing the study, if we based our conclusions only on survivor studies. Therefore, evidence in the younger general adult population without childhood cancer history was included in our search as well, leading to 175 general population studies with relevant data which were generalizable to young adult survivors.…”

Section: Discussionmentioning

confidence: 99%

Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review

et al. 2021

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Childhood cancer survivors (CCS) are at increased risk to develop metabolic syndrome (MetS), diabetes, and cardiovascular disease. Common criteria underestimate adiposity and possibly underdiagnose MetS, particularly after abdominal radiotherapy. A systematic literature review and meta-analysis on the diagnostic and predictive value of nine newer MetS related biomarkers (adiponectin, leptin, uric acid, hsCRP, TNF-alpha, IL-1, IL-6, apolipoprotein B (apoB), and lipoprotein(a) [lp(a)]) in survivors and adult non-cancer survivors was performed by searching PubMed and Embase. Evidence was summarized with GRADE after risk of bias evaluation (QUADAS-2/QUIPS). Eligible studies on promising biomarkers were pooled. We identified 175 general population and five CCS studies. In the general population, valuable predictive biomarkers are uric acid, adiponectin, hsCRP and apoB (high level of evidence), and leptin (moderate level of evidence). Valuable diagnostic biomarkers are hsCRP, adiponectin, uric acid, and leptin (low, low, moderate, and high level of evidence, respectively). Meta-analysis showed OR for hyperuricemia of 2.94 (age-/ sex-adjusted), OR per unit uric acid increase of 1.086 (unadjusted), and AUC for hsCRP of 0.71 (unadjusted). Uric acid, adiponectin, hsCRP, leptin, and apoB can be alternative biomarkers in the screening setting for MetS in survivors, to enhance early identification of those at high risk of subsequent complications.

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Section: Discussionmentioning

confidence: 99%

Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review

et al. 2021

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“…Bao et al37) evaluated the impact of exercise in a population-based prospective cohort study of 1,696 breast cancer survivors and showed that exercise was inversely associated with the prevalence of metabolic syndrome, and that regular exercise participation reduced its prevalence. Similarly, Grote et al38) studied the effects of exercise on patients who had survived different types of cancer, and their findings showed that a 3 day/week, 13-week exercise intervention improved the cardiometabolic health of cancer survivors. These investigators noted that the intervention was less effective in non-Caucasian survivors compared with Caucasian survivors, which warrants undertaking larger, multiethnic studies.…”

Section: Studies Into Intervention and Preventionmentioning

confidence: 99%

Metabolic syndrome induced by anticancer treatment in childhood cancer survivors

Chueh

Yoo

2017

Ann Pediatr Endocrinol Metab

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The number of childhood cancer survivors is increasing as survival rates improve. However, complications after treatment have not received much attention, particularly metabolic syndrome. Metabolic syndrome comprises central obesity, dyslipidemia, hypertension, and insulin resistance, and cancer survivors have higher risks of cardiovascular events compared with the general population. The mechanism by which cancer treatment induces metabolic syndrome is unclear. However, its pathophysiology can be categorized based on the cancer treatment type administered. Brain surgery or radiotherapy may induce metabolic syndrome by damaging the hypothalamic-pituitary axis, which may induce pituitary hormone deficiencies. Local therapy administered to particular endocrine organs directly damages the organs and causes hormone deficiencies, which induce obesity and dyslipidemia leading to metabolic syndrome. Chemotherapeutic agents interfere with cell generation and growth, damage the vascular endothelial cells, and increase the cardiovascular risk. Moreover, chemotherapeutic agents induce oxidative stress, which also induces metabolic syndrome. Physical inactivity caused by cancer treatment or the cancer itself, dietary restrictions, and the frequent use of antibiotics may also be risk factors for metabolic syndrome. Since childhood cancer survivors with metabolic syndrome have higher risks of cardiovascular events at an earlier age, early interventions should be considered. The optimal timing of interventions and drug use has not been established, but lifestyle modifications and exercise interventions that begin during cancer treatment might be beneficial and tailored education and interventions that account for individual patients' circumstances are needed. This review evaluates the recent literature that describes metabolic syndrome in cancer survivors, with a focus on its pathophysiology.

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“…The nature of training programs used with cancer survivors has remained a focus of research in an effort to devise the most effective strategy for fulfilling the needs of survivors. For instance, Grote et al investigated the efficacy of combined aerobic and resistance training for cancer survivors [22]. They found that improvement in cardiometabolic health is critical for preventing comorbidity among cancer survivors; in fact, it is as important as monitoring for the possible recurrence of cancer [22].…”

Section: Resultsmentioning

confidence: 99%

“…For instance, Grote et al investigated the efficacy of combined aerobic and resistance training for cancer survivors [22]. They found that improvement in cardiometabolic health is critical for preventing comorbidity among cancer survivors; in fact, it is as important as monitoring for the possible recurrence of cancer [22]. Further, Ligibel indicated the need to control for “energy balance factors, including diet, PA, and body weight,” in order to reduce the risk of cancer recurrence following treatment [23].…”

Section: Resultsmentioning

confidence: 99%

Impact of physical activity and diet on colorectal cancer survivors’ quality of life: a systematic review

2019

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Background Post-treatment management is essential for improving the health and quality of life of colorectal cancer (CRC) survivors. The number of cancer survivors is continually increasing, which is causing a corresponding growth in the need for effective post-treatment management programs. Current research on the topic indicates that such programs should include aspects such as physical activity and a proper diet, which would form the basis of lifestyle change among CRC survivors. Therefore, this study aimed to identify the impact of physical activity and diet on the quality of life of CRC survivors. Methods We performed a systematic literature review regarding CRC survivors. We searched the Embase, PubMed, and EBSCOhost databases, considering papers published between January 2000 and May 2017 in any language, using a combination of the following subject headings: “colorectal cancer,” “colorectal carcinoma survivor,” “survivorship plan,” “survivorship care plan,” “survivorship program,” “lifestyle,” “activities,” “exercise,” “diet program,” and “nutrition.” Results A total of 14,036 articles were identified, with 35 satisfying the eligibility criteria for the systematic review. These articles were grouped by the study questions into physical activity and diet: 24 articles were included in the physical activity group and 11 in the diet group. Conclusions The research showed that an effective survivorship program can significantly help CRC survivors maintain good health and quality of life for long periods. However, there is a lack of consensus and conclusive evidence regarding how the guidelines for such a program should be designed, in terms of both its form and content.

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Cardiometabolic Health Among Cancer Survivors: A 13-Week Pilot Study of a Combined Aerobic and Resistance Training Program

Cited by 7 publications

References 57 publications

Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review

Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review

Metabolic syndrome induced by anticancer treatment in childhood cancer survivors

Impact of physical activity and diet on colorectal cancer survivors’ quality of life: a systematic review

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