Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms

Schmitz, N.; Deschênes, Sonya S.; Burns, Rachel J.; Danna, Sofia M.; Franco, Oscar H.; Ikram, M. Arfan; Kivimäki, Mika; Singh‐Manoux, Archana; Tiemeier, Henning

doi:10.1192/bjp.2017.26

Cited by 27 publications

(20 citation statements)

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“…20 Furthermore, work shows that co-occurring cardiometabolic abnormalities and depressive symptoms are risk factors for cognitive decline. 21 However, to the best of our knowledge, no previous work has examined whether co-occurring cardiometabolic abnormalities and depression might be associated with incident dementia. The aim of the present study was to examine the impact of elevated depressive symptoms and cardiometabolic abnormalities on the incidence of dementia in a large community-dwelling sample of adults aged 50 years and older for more than 10 years.…”

Section: Introductionmentioning

confidence: 98%

Risk of dementia associated with cardiometabolic abnormalities and depressive symptoms: a longitudinal cohort study using the English longitudinal study of ageing

Kontari

Smith

2018

Int J Geriat Psychiatry

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Objectives Depression and cardiometabolic abnormalities are independently associated with a high risk of dementia. This study aimed to examine the association of comorbid depressive symptoms and cardiometabolic abnormalities with risk of dementia. Methods The sample comprised 4859 participants aged 50 or older without baseline dementia who took part in the English Longitudinal Study of Ageing (waves 2‐7). Depressive symptoms were assessed using the Center for Epidemiologic Studies‐Depression tool. Cardiometabolic abnormalities were defined as three or more cardiometabolic risk factors (inflammation, central obesity, raised triglycerides, low high‐density lipoprotein [HDL] cholesterol, hypertension, and hyperglycaemia or diabetes). Participants were classified into four groups based on presence of depressive symptoms and cardiometabolic abnormalities. Results were analysed using the Cox proportional hazards regression adjusted for covariates. Results A total of 216 cases of incident dementia were reported over 10 years of follow‐up. The group with high depressive symptoms only had an increased hazard of developing incident dementia during follow‐up (HR = 2.68; 95%CI, 1.70‐4.23), which was attenuated after adjustment for baseline cognition. No evidence was found for an association of overall cardiometabolic abnormalities with incident dementia; though hyperglycaemia, hypertension, and abdominal obesity with depressive symptoms had an unadjusted association with incident dementia. Only low‐HDL cholesterol with depressive symptoms had an adjusted association with incident dementia (HR = 0.18; 95%CI, 0.04‐0.75). Conclusions This work confirms depressive symptoms as a risk factor for incident dementia. However, low HDL‐cholesterol with depressive symptoms may be protective against dementia, though more work is required to confirm this association.

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Section: Introductionmentioning

confidence: 98%

Risk of dementia associated with cardiometabolic abnormalities and depressive symptoms: a longitudinal cohort study using the English longitudinal study of ageing

Kontari

Smith

2018

Int J Geriat Psychiatry

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“…High and increasing depressive symptom trajectories were associated with a higher mortality risk than stable low trajectories, while remitting trajectories were not associated with a higher risk [304]. Depressive symptoms were also found to be a mediator in the association of cardiometabolic dysregulations with cognitive decline [305]. Over the last three years, we also emphasized studying the role of sleep in brain health.…”

Section: Main Results In the Last 3 Yearsmentioning

confidence: 99%

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

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“…Neuroinflammation is a key pathological feature in disorders involving mood dysregulation such as depression and anxiety [55], as well as in cognitive alterations, which occur within the spectrum of normal cognitive aging, and in neurodegenerative disorders such as Alzheimer's disease [11,[13][14][15]. In fact, obesity and metabolic syndrome-characterized mainly by dysregulated metabolism of lipids and glucose-are independently associated with depression, and together they synergize its inflammatory pathway and worsen depressive symptoms and cognitive functions [56,57]. Moreover, depression induced by a high-fat diet is associated with alterations in intestinal microbiota, intestinal neuropeptides, and brain metabolome; it is also resistant to imipramine treatment [35].…”

Section: Discussionmentioning

confidence: 99%

Psychological Climacteric Symptoms and Attitudes toward Menopause among Emirati Women

Ali

Ahmed

Smail

2020

IJERPH

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Menopause is an inevitable developmental event that women encounter at an age of 42–54 years. The drop of estrogen levels that accompanies cessation of menstruation is associated with multiple vasomotor, physical, neuropsychological, and sexual symptoms, which may hamper quality of life. This study aimed to examine the severity of psychological symptoms and their correlates among peri- and postmenopausal Emirati women (N = 60, mean age = 54.88 ± 6 years). Participants were interviewed using the Menopause-Specific Quality of Life (MENQOL) and attitudes toward menopause scale (ATMS). In four path analysis models, vasomotor symptoms, weight gain, and fatigue had significant direct effects on symptoms of anxiety, depression (only weight gain and fatigue), and psychological distress. Fatigue significantly mediated the effects of vasomotor symptoms and weight gain on symptoms of anxiety, depression (only vasomotor symptoms), psychological distress, and memory problems. These models explained 47.6%, 44.5%, 56.6%, and 29.1% of the variances in anxiety, depression, psychological distress, and memory problems, respectively. Participants with more severe menopausal symptoms expressed more negative attitudes toward menopause though regression analysis revealed that only vasomotor symptoms could significantly contribute to ATMS scores. In conclusion, psychological distress is widespread among menopausal women, and it is associated with vasomotor symptoms, fatigue, and change of body composition (obesity). Psychological symptoms, along with vasomotor symptoms, express a key link to negative attitudes toward menopause. Therefore, interventional strategies that target psychological distress may promote coping with midlife transition and improve mental health among menopausal women.

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Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms

Abstract: Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline. Declaration of interest None.

Cited by 27 publications

References 46 publications

Risk of dementia associated with cardiometabolic abnormalities and depressive symptoms: a longitudinal cohort study using the English longitudinal study of ageing

Risk of dementia associated with cardiometabolic abnormalities and depressive symptoms: a longitudinal cohort study using the English longitudinal study of ageing

Objectives, design and main findings until 2020 from the Rotterdam Study

Psychological Climacteric Symptoms and Attitudes toward Menopause among Emirati Women

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