Cardiometabolic determinants of early and advanced brain alterations: Insights from conventional and novel MRI techniques

Vergoossen, Laura; Jansen, Jacobus F.A.; Backes, Walter H.; Schram, Miranda T.

doi:10.1016/j.neubiorev.2020.04.001

Cited by 9 publications

(10 citation statements)

References 174 publications

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“…These neuroimaging findings agree with those from postmortem research demonstrating that community-level disadvantage associates with a greater severity of neurofibrillary tangles, neuritic plaque staging, and cerebral amyloid angiopathy seen on autopsy (18). Collectively, these findings agree with other lines of evidence indicating that elevated cardiometabolic risk predicts future cognitive decline and some dementias, such as vascular dementia and Alzheimer’s disease, which themselves associate with socioeconomic disadvantage (27–30).…”

Section: Introductionsupporting

confidence: 90%

“…Educational, occupational, and financial dimensions of socioeconomic disadvantage measured at the level of communities (i.e., residential areas) have long been associated with elevated rates of cardiometabolic risk factors and their clinical sequelae (e.g., (1,2,5,8,56)). In turn, cardiometabolic risk factors seem to confer the risk of premature cognitive decline, adverse functional and structural changes in the brain, and several dementias (25,(27)(28)(29)(30)46,(57)(58)(59)(60)(61)(62)(63). Notably, community-level disadvantage itself has also been related to poorer cognitive function, dementia risk, and accelerated cognitive decline (14,15,(20)(21)(22)(23)(24)26), which may be attributable in part to cardiometabolic risk factors linked to premature brain aging and dementia risk.…”

Section: Discussionmentioning

confidence: 99%

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Beyond Neighborhood Disadvantage: Local Resources, Green Space, Pollution, and Crime as Residential Community Correlates of Cardiovascular Risk and Brain Morphology in Midlife Adults

et al. 2023

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Objective: Residing in communities characterized by socioeconomic disadvantage confers risk of cardiometabolic diseases. Residing in disadvantaged communities may also confer the risk of neurodegenerative brain changes via cardiometabolic pathways. This study tested whether features of communities-apart from conventional socioeconomic characteristics-relate not only to cardiometabolic risk but also to relative tissue reductions in the cerebral cortex and hippocampus. Methods: Participants were 699 adults aged 30 to 54 years (340 women; 22.5% non-White) whose addresses were geocoded to compute community indicators of socioeconomic disadvantage, as well as air and toxic chemical pollutant exposures, homicide rates, concentration of employment opportunities, land use (green space), and availability of supermarkets and local resources. Participants also underwent assessments of cortical and hippocampal volumes and cardiometabolic risk factors (adiposity, blood pressure, fasting glucose, and lipids). Results: Multilevel structural equation modeling demonstrated that cardiometabolic risk was associated with community disadvantage (β = 0.10, 95% confidence interval [CI] = 0.01 to 0.18), as well as chemical pollution (β = 0.11, 95% CI = 0.02 to 0.19), homicide rates (β = 0.10, 95% CI = 0.01 to 0.18), employment opportunities (β = −0.16, 95% CI = −0.27 to −0.04), and green space (β = −0.12, 95% CI = −0.20 to −0.04). Moreover, cardiometabolic risk indirectly mediated the associations of several of these community features and brain tissue volumes. Some associations were nonlinear, and none were explained by participants' individual-level socioeconomic characteristics. Conclusions: Features of communities other than conventional indicators of socioeconomic disadvantage may represent nonredundant correlates of cardiometabolic risk and brain tissue morphology in midlife.

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Section: Introductionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Beyond Neighborhood Disadvantage: Local Resources, Green Space, Pollution, and Crime as Residential Community Correlates of Cardiovascular Risk and Brain Morphology in Midlife Adults

et al. 2023

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“…is of interest because periventricular WMHs are located in areas with a high density of long-association white matter tracts that connect various widely distributed cortical regions supporting multiple cognitive functions. Similarly, initially it was thought that only the extensive level of WMH load would impair cognitive function, whereas currently it is clear that cardiovascular risk factors are associated with cSVD and cognitive performance (7).…”

Section: Key Resultsmentioning

confidence: 99%

“…The Maastricht Study We used data from the Maastricht Study, an observational prospective population-based cohort study. The rationale and methodology have been described previously (7). In brief, the study focuses on the cause, pathophysiology, atlas-guided tract reconstruction (20) (Fig 2).…”

Section: Methodsmentioning

confidence: 99%

Interplay of White Matter Hyperintensities, Cerebral Networks, and Cognitive Function in an Adult Population: Diffusion-Tensor Imaging in the Maastricht Study

Vergoossen¹,

Jansen²,

Sloten³

et al. 2021

Radiology

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“…Previous studies that related structural brain abnormalities to depression and cognition mainly included elderly populations, and sex differences are found in both MDD (WHO, 2017 ) and structural brain abnormalities (Ruigrok et al, 2014 ). Furthermore, it has been shown that type 2 diabetes mellitus (T2DM) is associated with MDD (Roy & Lloyd, 2012 ), cognitive functioning (Reijmer, van den Berg, Ruis, Jaap Kappelle, & Biessels, 2010 ), and structural brain abnormalities (Vergoossen, Jansen, Backes, & Schram, 2020 ). Because of this, we tested whether associations differed according to sex, age, and T2DM status in a cohort enriched for T2DM.…”

Section: Introductionmentioning

confidence: 99%

The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study

et al. 2021

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Background Individuals with depression often experience widespread and persistent cognitive deficits, which might be due to brain atrophy and cerebral small vessel disease (CSVD). We therefore studied the associations between depression, markers of brain atrophy and CSVD, and cognitive functioning. Methods We used cross-sectional data from the population-based Maastricht study (n = 4734; mean age 59.1 ± 8.6 years, 50.2% women), which focuses on type 2 diabetes. A current episode of major depressive disorder (MDD, n = 151) was assessed by the Mini-International Neuropsychiatric Interview. Volumes of cerebral spinal fluid, white matter, gray matter and white matter hyperintensities, presence of lacunar infarcts and cerebral microbleeds, and total CSVD burden were assessed by 3 T magnetic resonance imaging. Multiple linear and logistic regression analyses tested the associations between MDD, brain markers and cognitive functioning in memory, information processing speed, and executive functioning & attention, and presence of cognitive impairment. Structural equation modeling was used to test mediation. Results In fully adjusted models, MDD was associated with lower scores in information processing speed [mean difference = −0.18(−0.28;−0.08)], executive functioning & attention [mean difference = −0.13(−0.25;−0.02)], and with higher odds of cognitive impairment [odds ratio (OR) = 1.60(1.06;2.40)]. MDD was associated with CSVD in participants without type 2 diabetes [OR = 1.65(1.06;2.56)], but CSVD or other markers of brain atrophy or CSVD did not mediate the association with cognitive functioning. Conclusions MDD is associated with more impaired information processing speed and executive functioning & attention, and overall cognitive impairment. Furthermore, MDD was associated with CSVD in participants without type 2 diabetes, but this association did not explain an impaired cognitive profile.

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Cardiometabolic determinants of early and advanced brain alterations: Insights from conventional and novel MRI techniques

Cited by 9 publications

References 174 publications

Beyond Neighborhood Disadvantage: Local Resources, Green Space, Pollution, and Crime as Residential Community Correlates of Cardiovascular Risk and Brain Morphology in Midlife Adults

Beyond Neighborhood Disadvantage: Local Resources, Green Space, Pollution, and Crime as Residential Community Correlates of Cardiovascular Risk and Brain Morphology in Midlife Adults

Interplay of White Matter Hyperintensities, Cerebral Networks, and Cognitive Function in an Adult Population: Diffusion-Tensor Imaging in the Maastricht Study

The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study

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