“…7 , “tissue plasminogen activator” and “acute stroke” were the keywords with the earliest citation outbreaks, which represent the initial status of two keywords in ischemic stroke research [ 53 ]. From 2016 to 2022, the second stage, the citation bursts of keywords, such as “endothelial cell”, “blood brain barrier”, “neuroprotective effect”, “blood-brain barrier”, “inflammation”, “cognitive dysfunction” and “mitochondrial dysfunction” reflect the potential in these directions, focus on basic experiments as well as molecular biology mechanism studies [ [54] , [55] , [56] , [57] , [58] ]. Additionally, “mechanism”, “signaling pathway”, “underlying mechanism”, “leading cause” and “positive effect” are also citation bursts keywords related to mechanisms that have been widely concerned by scholars in recent years [ 59 , 60 ].…”