Cardioglobulin B Content of the Blood Plasma of Newborn Infants

Abstract

A comparative study was made of the cardioglobulin B content of the plasma of 26 normal adults and 20 newborn infants with the bioassay technique described by Hajdu and Leonard. The cardioglobulin B content in the plasma of infants was significantly lower than that of adults. Heparin was used as the anticoagulant in the blood samples throughout this study. It was noted that, when heparin containing phenol as a preservative was employed, the cardioglobulin B levels were lower in both groups.

Chronic Allogeneic Disease

“…Experimentally, antiglomerular basement membrane antibodies can be induced by immunization with heterologous (28), homologous (29) or autologous (30) basement membranes. The lesion proyoked by these antibodies is a mixed proliferative and membranous glomerulo-nephritis that has as its primary electron microscopic change an irregular thickening of the luminal aspect of basement membranes accompanied by focal subendothelial deposits of electron-dense material (31). The immunofluorescent staining pattern in this lesion is a smooth, uniform, linear fluorescence overlying all glomerular capillary basement membranes (32).…”