Cardiogenic shock complicating acute coronary syndromes: Insights from the Global Registry of Acute Coronary Events

Awad, Hamza H.; Anderson, Frederick A.; Gore, Joel M.; Goodman, Shaun G.; Goldberg, Robert J.

doi:10.1016/j.ahj.2012.03.003

Cited by 100 publications

(90 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are consistent with the results from previous studies9, 13, 14, 15 On the other hand, patients who had a history of previously diagnosed stroke were less likely to have developed prehospital and early CS. In the GRACE study, the frequency of having a previous stroke was higher in patients who developed in‐hospital CS than in patients who did not develop CS15 whereas results from the SPRINT (Systolic Blood Pressure Intervention Trial) study found that a history of stroke was an independent predictor for the development of in‐hospital CS 12…”

Section: Discussionsupporting

confidence: 92%

“…Our results are consistent with findings from the AMIS Plus registry and the GRACE study, which showed that the CFRs associated with in‐hospital CS were higher than that associated with prehospital CS 9, 15. One possible explanation is that patients with late CS are more likely to be older, to have more comorbidities present, and to develop other clinical complications compared with patients with prehospital CS.…”

Section: Discussionsupporting

confidence: 90%

“…The in‐hospital CFRs associated with early or late CS in the present study declined between 2001–2003 and 2009–2011, which are consistent with the results of previous studies 7, 9, 15. In the AMIS Plus study, the hospital CFRs for CS developing during hospitalization for AMI declined from 60.9% to 48.9% between 1997 and 2006 9.…”

Section: Discussionsupporting

confidence: 90%

“…In the AMIS Plus registry, the frequency of in‐hospital CS decreased from 10.6% in 1997 to 2.7% in 2006 9. Similarly, there was a declining trend in the frequency of in‐hospital CS between 1999 and 2007 (5.1% versus 3.6%) in the GRACE study 15. Data from 3 national French registries of more than 7500 patients hospitalized with AMI in 1995, 2000, and 2005 also showed declines in the prevalence of CS over time from 6.9% in 1995 to 5.7% in 2005 25.…”

Section: Discussionmentioning

confidence: 96%

“…The pathophysiology, hospital management, and outcomes associated with CS are likely to be different for patients who develop this complication prehospital or at varying time intervals during hospitalization for AMI. However, data in this area are very limited or from the distant past 7, 14, 15, 16…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Ten‐Year (2001–2011) Trends in the Incidence Rates and Short‐Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction

Nguyen

Yarzebski

Lessard

et al. 2017

JAHA

Self Cite

View full text Add to dashboard Cite

BackgroundCardiogenic shock (CS) is a serious complication of acute myocardial infarction, and the time of onset of CS has a potential role in influencing its prognosis. Limited contemporary data exist on this complication, however, especially from a population‐based perspective. Our study objectives were to describe decade‐long trends in the incidence, in‐hospital mortality, and factors associated with the development of CS in 3 temporal contexts: (1) before hospital arrival for acute myocardial infarction (prehospital CS); (2) within 24 hours of hospitalization (early CS); and (3) ≥24 hours after hospitalization (late CS).Methods and ResultsThe study population consisted of 5782 patients with an acute myocardial infarction who were admitted to all 11 hospitals in central Massachusetts on a biennial basis between 2001 and 2011. The overall proportion of patients who developed CS was 5.2%. The proportion of patients with prehospital CS (1.6%) and late CS (1.5%) remained stable over time, whereas the proportion of patients with early CS declined from 2.2% in 2001–2003 to 1.2% in 2009–2011. In‐hospital mortality for prehospital CS increased from 38.9% in 2001–2003 to 53.6% in 2009–2011, whereas in‐hospital mortality for early and late CS decreased over time (35.9% and 64.7% in 2001–2003 to 15.8% and 39.1% in 2009–2011, respectively).ConclusionsDevelopment of prehospital and in‐hospital CS was associated with poor short‐term survival and the in‐hospital death rates among those with prehospital CS increased over time. Interventions focused on preventing or treating prehospital and late CS are needed to improve in‐hospital survival after acute myocardial infarction.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ten‐Year (2001–2011) Trends in the Incidence Rates and Short‐Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction

Nguyen

Yarzebski

Lessard

et al. 2017

JAHA

Self Cite

View full text Add to dashboard Cite

show abstract

Outcomes in Women and Minorities Compared With White Men 1 Year After Everolimus-Eluting Stent Implantation

et al. 2017

View full text Add to dashboard Cite

show abstract

Intra-aortic Balloon Pump Therapy for Acute Myocardial Infarction

et al. 2015

View full text Add to dashboard Cite

IMPORTANCE Intra-aortic balloon pump (IABP) therapy is a widely used intervention for acute myocardial infarction with cardiogenic shock. Guidelines, which previously strongly recommended it, have recently undergone substantial change.OBJECTIVE To assess IABP efficacy in acute myocardial infarction.DATA SOURCES Human studies found in Pubmed, Embase, and Cochrane libraries through December 2014 and in reference lists of selected articles. Search strings were "myocardial infarction" or "acute coronary syndrome" and "intra-aortic balloon pump" or "counterpulsation."STUDY SELECTION Randomized clinical trials (RCTs) and observational studies comparing use of IABP with no IABP in patients with acute myocardial infarction. DATA EXTRACTION AND SYNTHESISTwo reviewers independently extracted the data, and risk of bias in RCTs was assessed using the Cochrane risk of bias tool. We conducted separate meta-analyses of the RCTs and observational studies. Data were quantitatively synthesized using random-effects meta-analysis. MAIN OUTCOMES AND MEASURES Thirty-day mortality.RESULTS There were 12 eligible RCTs randomizing 2123 patients. In the RCTs, IABP use had no statistically significant effect on mortality (odds ratio [OR], 0.96 [95% CI, 0.74-1.24]), with no significant heterogeneity among trials (I 2 = 0%; P = .52). This result was consistent when studies were stratified by the presence (OR, 0.94 [95% CI, 0.69-1.28]; P = .69, I 2 = 0%) or absence (OR, 0.98 [95% CI, 0.57-1.69]; P = .95, I 2 = 17%) of cardiogenic shock. There were 15 eligible observational studies totaling 15 530 patients. Their results were mutually conflicting (heterogeneity I 2 = 97%; P < .001), causing wide uncertainty in the summary estimate for the association with mortality (OR, 0.96 [95% CI, 0.54-1.70]). A simple index of baseline risk marker imbalance in the observational studies appeared to explain much of the heterogeneity in the observational data (R 2 meta = 46.2%; P < .001).CONCLUSIONS AND RELEVANCE Use of IABP was not found to improve mortality among patients with acute myocardial infarction in the RCTs, regardless of whether patients had cardiogenic shock. The observational studies showed a variety of mutually contradictory associations between IABP therapy and mortality, much of which was explained by the differences between studies in the balance of risk factors between IABP and non-IABP groups.

show abstract

Cardiogenic shock complicating acute coronary syndromes: Insights from the Global Registry of Acute Coronary Events

Cited by 100 publications

References 27 publications

Ten‐Year (2001–2011) Trends in the Incidence Rates and Short‐Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction

Ten‐Year (2001–2011) Trends in the Incidence Rates and Short‐Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction

Outcomes in Women and Minorities Compared With White Men 1 Year After Everolimus-Eluting Stent Implantation

Intra-aortic Balloon Pump Therapy for Acute Myocardial Infarction

Contact Info

Product

Resources

About