Cardiogenic Shock: A Rare Complication of Influenza

Hashmi, Arsalan Talib; Yousuf, Muhammad Sohail; Waseem, Husnain; Ambesh, Paurush; Rodríguez, Daniel; Adzic, Aleksander

doi:10.7759/cureus.2549

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Our literature review identified 75 unique cases (55 adult and 20 pediatric patients) from 56 case reports, and 5 case series describing 2 to 8 patients each, published from 1959 through 2021 [ 2 , 12 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ,…”

Section: Resultsmentioning

confidence: 99%

Influenza Myopericarditis and Pericarditis: A Literature Review

Radovanovic

Petrović

Barsoum

et al. 2022

JCM

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Myopericarditis is a rare complication of influenza infection. The presentation may range from mild and frequently unrecognized, to fulminant and potentially complicated by cardiogenic and/or obstructive shock (tamponade), which is associated with high mortality. We performed a review of literature on all influenza pericarditis and myopericarditis cases according to PRISMA guidelines using the PubMed search engine of the Medline database. Seventy-five cases of influenza myopericarditis and isolated pericarditis were identified from 1951 to 2021. Influenza A was reported twice as often as influenza B; however, influenza type did not correlate with outcome. Men and elderly patients were more likely to have isolated pericarditis, while women and younger patients were more likely to have myopericarditis. All included patients had pericardial effusion, while 36% had tamponade. Tamponade was more common in those with isolated pericarditis (41.2%) than myopericarditis (13.8%). Cardiogenic shock was more common in patients with myopericarditis (64%), with an overall mortality rate of 14.7%. Nearly 88% of the recovered patients remained without long-term complications reported. Conclusion: Influenza A appears a more common cause of pericarditis and myopericarditis. Isolated pericarditis was more commonly associated with tamponade but without reported deaths, whereas myopericarditis was more commonly associated with cardiogenic shock and death (19%).

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Section: Resultsmentioning

confidence: 99%

Influenza Myopericarditis and Pericarditis: A Literature Review

Radovanovic

Petrović

Barsoum

et al. 2022

JCM

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“…The current analysis corroborates the results of previous studies that did not show an associated increase in the incidence of cerebrovascular accidents with viral influenza. Cardiogenic shock associated with viral influenza is a very rare clinical entity that usually results from viral myocarditis 27. Unlike some other viruses such as coxsackie viruses, influenza appears to have low affinity for cardiac myocytes, which explains the very low incidence of this disease entity and the lack of an association between influenza infection and cardiogenic shock in the current analysis 28.…”

Section: Discussionmentioning

confidence: 81%

Inpatient cardiovascular outcomes in patients with cancer affected by viral influenza infection

Sheth

Grewal

Patel

et al. 2022

Postgraduate Medical Journal

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BackgroundInfluenza disproportionately affects individuals with underlying comorbidities. Long-term follow-up studies have shown that patients with cancer with influenza have higher mortality. However, very little is known about the in-hospital mortality and cardiovascular outcomes of influenza infection in cancer hospitalisations.MethodsWe compared the in-hospital mortality and cardiovascular outcomes in patients with cancer with and without influenza by screening the National Inpatient Sample from 2015 to 2017. A total of 9 443 421 hospitalisations with any cancer were identified, out of which 14 634 had influenza while 9 252 007 did not. A two-level hierarchical multivariate logistic regression analysis adjusted for age, sex, race, hospital type and relevant comorbidities was performed.ResultsThe group with cancer and influenza had higher in-hospital mortality (OR 1.08; 95% CI 1.003 to 1.16; p=0.04), acute coronary syndromes (OR 1.74; 95% CI 1.57 to 1.93; p<0.0001), atrial fibrillation (OR 1.24; 95% CI 1.18 to 1.29; p<0.0001) and acute heart failure (OR 1.41; 95% CI 1.32 to 1.51; p<0.0001).ConclusionPatients with cancer affected by influenza have higher in-hospital mortality and a higher prevalence of acute coronary syndrome, atrial fibrillation and acute heart failure.

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Impact of pulmonary hypertension on outcomes of influenza pneumonia patients: A nationwide analysis

Jain,

Raval,

Modi

et al. 2023

F1000Res

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Background: Pulmonary hypertension can be a significant cause of morbidity and mortality for influenza pneumonia (IP) patients. We performed analysis from the multicentric National Inpatient Sample (NIS) datasets to study the influence of disorders of pulmonary hypertension on the outcomes in IP patients. Methods: We used NIS 2016–2019 to identify IP hospitalizations (between 22–90 years of age) and divided them into with and without pulmonary hypertension (herein PHDPC). We analyzed for differences in demographics, primary (all-cause mortality) and other secondary outcomes. Results: Of 353,460 IP hospitalizations, 6.5% had PHDPC. The PHDPC cohort had more elderly, females, African Americans, and Medicare enrollees predominantly with more hospitalizations to large bed sizes and urban teaching hospitals, and higher cardiovascular comorbidities than non-PHDPC cohort. PHDPC had higher primary outcomes for in-hospital mortality (8.9% vs. 5.8%, adjusted OR 1.4, 95% CI: 1.21–1.61). PHDPC also had higher secondary outcomes for sepsis, septic shock, cardiogenic shock and need for mechanical ventilation, prolonged ventilation, hospital resource utilization for longer mean length of stay, mean hospitalization cost, transfer to other facilities or need for home health care, and high risk for 30-day readmission than the non-PHDPC cohort. Conclusions: With our study, we provide contemporary data for the outcomes of IP inpatients with pulmonary hypertension and depict worse outcomes for mortality, complications, and hospital resource utilization. Although our study does not include stratification for vaccination status for the outcome, primary care physicians, cardiologists, and pulmonologists should pro-actively educate patients on preventive strategies during the flu season.

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Cardiogenic Shock: A Rare Complication of Influenza

Cited by 3 publications

References 10 publications

Influenza Myopericarditis and Pericarditis: A Literature Review

Influenza Myopericarditis and Pericarditis: A Literature Review

Inpatient cardiovascular outcomes in patients with cancer affected by viral influenza infection

Impact of pulmonary hypertension on outcomes of influenza pneumonia patients: A nationwide analysis

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