CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart

Kashem, Abul; Santamore, William P.; Hassan, Sarmina; Melvin, David; Crabbe, Deborah L.; Margulies, Kenneth B.; Goldman, Bruce; Llort, Frank; Krieger, Benjamin; Lesniak, B.

doi:10.1046/j.1540-8191.18.s2.5.x

Cited by 6 publications

(8 citation statements)

References 23 publications

(35 reference statements)

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“…Avoidance of a high‐risk procedure in less symptomatic patients has led to a search for less invasive yet equally effective procedures, including cardiac wrapping, 4 piercing, 5 and clasping 6 . Each intends to change the geometry of the dilated and spherical left ventricle to a flattened one to reduce radius and/or wall tension (Fig.…”

Section: Less Invasive Volume Reductionsmentioning

confidence: 99%

“…Partial left ventriculectomy (PLV) has been abandoned in many institutions where it was attempted in desperate cases with a prohibitive mortality 1 . Nonetheless, instances of dramatic improvements prompted a search for indices to identify patients more likely to respond favorably to this operation, 2,3 or to similar procedures with reduced risks 4–6 . At the same time, ventricular reshaping procedures for ischemic cardiomyopathy have gained popularity and directed attention to the left ventricle as a surgical target 7 .…”

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confidence: 99%

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Ventricular Volume Reduction Procedures

Kawaguchi

Bergsland

Linde

2003

Journal of Cardiac Surgery

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Although partial left ventriculectomy (PLV) has been abandoned in many institutions, a few hospitals continue to perform it with a relatively favorable outcome. Other volume reduction procedures have become popular with renewed interest in ventricular reshaping to improve function. Although recent refined selection criteria have improved survival with PLV, earlier unpredictable results prompted less invasive procedures based on the same physiologic concept of reducing radius or wall tension by wrapping, piercing, or clasping. These new techniques are not only less invasive but also reversible and adjustable and appear safer for less symptomatic patients at risk of progressive heart failure. Nonetheless, mechanisms of action and degrees of volume reduction and/or restriction need to be delineated before widespread clinical application.

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Section: Less Invasive Volume Reductionsmentioning

confidence: 99%

mentioning

confidence: 99%

Ventricular Volume Reduction Procedures

Kawaguchi

Bergsland

Linde

2003

Journal of Cardiac Surgery

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“…This work was supported by the National Institute of Health grants HL057952 and HL095608 and a is a reduction in LV remodeling [80][81][82][83][84]. These devices can be placed at the time pacing DCM has become manifest, or at earlier time points during the development of this process [80][81][82][83][84].…”

Section: Acknowledgementsmentioning

confidence: 99%

“…These devices can be placed at the time pacing DCM has become manifest, or at earlier time points during the development of this process [80][81][82][83][84]. However, it should be pointed out that with the development of pacing-induced DCM and progression to CHF, significant hemodynamic instability and an arrhythmogenic substrate can be encountered.…”

Section: Acknowledgementsmentioning

confidence: 99%

“…However, it should be pointed out that with the development of pacing-induced DCM and progression to CHF, significant hemodynamic instability and an arrhythmogenic substrate can be encountered. Nevertheless, due to the significant uniformity of the LV remodeling process and the clear recapitulation of the DCM phenotype, the pacing model can be utilized to examine the acute effects of myocardial restraint devices [80,83]. Furthermore, as described in an earlier section, pacing-induced DCM is associated with significant MR, and therefore the use of these passive restraint devices to evaluate the effects on this response variable is possible [8,83,84].…”

Section: Acknowledgementsmentioning

confidence: 99%

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Models of Pacing‐Induced Heart Failure

Shuman

Mukherjee

Spinale

2013

Manual of Research Techniques in Cardiovascular Medicine

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Physiological Implications of Myocardial Scar Structure

Richardson

Clarke

Quinn

et al. 2015

Comprehensive Physiology

234

201

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Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of several weeks. The size, location, composition, structure and mechanical properties of the healing scar are all critical determinants of the fate of patients who survive the initial infarction. While the central importance of scar structure in determining pump function and remodeling has long been recognized, it has proven remarkably difficult to design therapies that improve heart function or limit remodeling by modifying scar structure. Many exciting new therapies are under development, but predicting their long-term effects requires a detailed understanding of how infarct scar forms, how its properties impact left ventricular function and remodeling, and how changes in scar structure and properties feed back to affect not only heart mechanics but also electrical conduction, reflex hemodynamic compensations, and the ongoing process of scar formation itself. In this article, we outline the scar formation process following an MI, discuss interpretation of standard measures of heart function in the setting of a healing infarct, then present implications of infarct scar geometry and structure for both mechanical and electrical function of the heart and summarize experiences to date with therapeutic interventions that aim to modify scar geometry and structure. One important conclusion that emerges from the studies reviewed here is that computational modeling is an essential tool for integrating the wealth of information required to understand this complex system and predict the impact of novel therapies on scar healing, heart function, and remodeling following myocardial infarction.

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CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart

Cited by 6 publications

References 23 publications

Ventricular Volume Reduction Procedures

Ventricular Volume Reduction Procedures

Models of Pacing‐Induced Heart Failure

Physiological Implications of Myocardial Scar Structure

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