Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

El-Missiry, Mohamed A; Amer, Maggie E.; Hemieda, Faried Abdel-Kader El-Sayed; Othman, Azza I.; Sakr, Doaa A.; Abdulhadi, Haitham L.

doi:10.1016/j.ejbas.2015.09.004

Cited by 30 publications

(24 citation statements)

References 58 publications

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“…This caused insufficient production of insulin and consequently the elevation of blood glucose level. In the present study, induction of type-2 diabetes with STZ/nicotinamide significantly increased the glucose level and this hyperglycaemic action of STZ was confirmed by many previous studies [24,67,68,69,70,71,72] In the present study, treatment of diabetic groups with processed cheese spreads with 3.5% cress seed showed powerful antidiabetic properties, as it decreased blood glucose level. In a similar manner, the antihyperglycemic effect of cress seed was investigated in STZ-induced diabetic rats that were orally administrated cress seed aqueous extract for 16 days [73].…”

Section: Effect Of Processed Cheese Spreads With 35% Cress Seed On Plasma Glucose Level (Mg/dl)supporting

confidence: 88%

Cress Seed (Lepidium sativum) Role in the healthy Processed Spread Cheese and Its Anti-Diabetic Activity

Mohamed¹,

Hussein²

2017

IJEAB

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The present study dealt with utilization of cress seeds (Lepidium sativum) in the manufacture of processed spread cheese, instead of emulsifying salt. Cress seed have also health promoting properties especially lowering glucose ratios. Cress seeds powder were prepared and added with the ingredients during manufacture of processed spread cheese at levels of six ratios (0.05, 1.5, 2.5, 3.5, 4.5 and 5.5%) compared with control (3% commercial emulsifying salt). The chemical, physical, microbiology and organoleptic properties of resultant samples were evaluated. Data revealed that processed spread cheese sample fortified with 3.5% cress seeds was the best either when fresh or during storage (8±2ºC for 3 months) and they had acceptable properties. Microstructure of processed cheese spread samples were also conducted. From nutritional view, processed cheese spread samples fortified with 3.5% cress seeds were used for feeding Adult male albino rats to study their effect on plasma glucose level. Obtained data indicated that the glucose level in plasma was significantly decreased (P<0.01) compared with the diabetic group. Data revealed that using of 3.5% cress seeds as a natural emulsifier agent succeed in prepare acceptable processed spread cheese sample and led to decrease plasma glucose level in Adult male albino rats.

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Section: Effect Of Processed Cheese Spreads With 35% Cress Seed On Plasma Glucose Level (Mg/dl)supporting

confidence: 88%

Cress Seed (Lepidium sativum) Role in the healthy Processed Spread Cheese and Its Anti-Diabetic Activity

Mohamed¹,

Hussein²

2017

IJEAB

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“…In the current study, the 4-HNE level, a lipid peroxidation product, was remarkably increased in the heart and pancreas and was significantly higher in T2DM rats than in the normal control rats, indicating an excessive oxidative stress state. The increased oxidative stress in diabetic rats may result from the continuous generation of ROS produced by hyperglycemia and glucose autoxidation [ 50 , 51 ]. This expression is accompanied by a significant decrease in the GSH content and GPx activity in cardiac and pancreatic tissues.…”

Section: Discussionmentioning

confidence: 99%

Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

Abdulwahab

El-Missiry

Shabana

et al. 2021

Heliyon

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Cardiomyopathy and pancreatic injury are health issues associated with type 2 diabetes mellitus (T2DM) and are characterized by elevated oxidative stress, inflammation and apoptosis. Melatonin (MLT) is a hormone with multifunctional antioxidant activity. The protective effects of MLT on the heart and pancreas during the early development of diabetic cardiomyopathy and pancreatic injury were investigated in male Wistar rats with T2DM. MLT (10 mg/kg) was administered daily by gavage for 15 days after diabetic induction. Treatment of diabetic rats with MLT significantly normalized the levels of serum glucose, HbA1-c, and the lipid profile and improved the insulin levels and insulin resistance compared with diabetic rats, affirming its antidiabetic effect. MLT significantly prevented the development of oxidative stress and sustained the levels of glutathione and glutathione peroxidase activity in the heart and pancreas of diabetic animals, indicating its antioxidant capacity. Additionally, MLT prevented the increase in proinflammatory cytokines and expression of Bax, caspase-3 and P53. Furthermore, MLT enhanced the anti-inflammatory cytokine IL-10 and antiapoptotic protein Bcl-2. MLT controlled the levels of troponin T and creatine kinase-MB and lactate dehydrogenase activity, indicating its anti-inflammatory and antiapoptotic effects. Histological examinations confirmed the protective effects of MLT on T2DM-induced injury in the myocardium, pancreas and islets of Langerhans. In conclusion, the protective effects of melatonin on the heart and pancreas during the early development of T2DM are attributed to its antihyperglycemic, antilipidemic and antioxidant influences as well as its remarkable anti-inflammatory and antiapoptotic properties.

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“…Ag has anti-inflammatory properties in addition to increasing re-epithelization [ 68 ], and silver nanoparticles may improve anti-inflammatory activity in wounds, accelerating this repair process [ 56 ]. The anti-inflammatory effects of pomegranate extracts were also widely explored [ 50 , 69 , 70 ], and punicalagin is highly involved with this anti-inflammatory capacity [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats

et al. 2021

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Infected cutaneous ulcers from diabetic rats with Candida albicans and Streptococcus aureus were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound development and infection, the treatments were performed twice per day for 14 days. The wound healing was analyzed on days 2, 7, and 14 through the determination of CFUs, inflammatory infiltrate, angiogenesis, fibroplasia, myeloperoxidase, and collagen determination. Expressive improvement in wound healing was noted using both silver nanoparticles for 7 days. All the treatments were superior to controls and promoted significant S. aureus reduction after 14 days. CS presented better anti-inflammatory results, and GS and CS the highest number of fibroblasts. Despite the techniques’ limitations, GS and CS demonstrated considerable potential for managing infected wounds, especially considering no early strategies prior to the drugs, such as the debridement of these wounds, were included.

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Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

Cited by 30 publications

References 58 publications

Cress Seed (Lepidium sativum) Role in the healthy Processed Spread Cheese and Its Anti-Diabetic Activity

Cress Seed (Lepidium sativum) Role in the healthy Processed Spread Cheese and Its Anti-Diabetic Activity

Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats

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