Cardioactive effects of Eremophila alternifolia extracts

Interesting biological activities from plants traditionally used by Native Australians

“…Heart rate was significantly increased by three of the four doses tested. This is consistent with similar reports by Pennacchio et al (1995), who showed that the methanol extract of Eremophila alternifolia leaves significantly increased chronotropism in Langendorff rat hearts. That study led to the isolation of a phenylethanoid glycoside called verbascoside (syn.…”

“…Australian and other researchers have only just started to realize the extent of this knowledge, much of which was lost following European colonization. A number of subsequent studies have recently revealed that some of the plants used by Native Australians produce useful biologically active compounds (Pennacchio et al, 1995(Pennacchio et al, , 1996a(Pennacchio et al, ,b, 1999Wickens and Pennacchio, 2002). We now report on the interesting antibiotic and cardioactive properties that arose from an investigation of four routinely used plant species.…”

Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish

“…1) Due to its potential medicinal value, this plant has been the focus of much attention in the search for pharmacologically significant compounds. A number of phenylethanoid glycosides, including acteoside, isoacteoside, 2′-O-acetylacteoside, brandioside, arenarioside, and poliumoside, have been characterized from B. hancei 1−4) and reported to exhibit diverse and potentially significant pharmacological activities, including antiproliferative, 4) antioxidant, 5) antiinflammatory, 6) anticancer, 7) hepatoprotective, 8) antinephritic, 9) cardioactive, 10) and antimicrobial 11) effects. Flavonoids and iridoid glycosides are also common in the Scrophulariaceae family, but only the flavone, luteolin, and iridoid glycoside, mussaenoside, have been found in B. hancei.…”

Policy lessons from practice: Australian bush products for commercial markets

“…To the surprise of many Aboriginal people with traditional connections to this genus, the chemistry of most Eremophila species has been investigated. Many species have been tested for their active ingredients by Australian and international scientists and findings are in the public domain (for example Ghisalberti 1994;Grice et al 2003;Ndi et al 2007;Owen and Palombo 2007;Pennacchio et al 1995).…”