Cardio-Oncology in Cuba

Bazan, Manuel; Mestre, Braulio; Peix, Amalia

doi:10.1016/j.jaccao.2020.11.014

Cited by 2 publications

(1 citation statement)

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“…In Cuba, cancer is the second leading cause of death. Over the last 20 years, the most common causes of cancer death in Cuba have been lung, prostate, and colon cancers in men and lung, breast, and colon cancers in women [3].…”

Section: Introductionmentioning

confidence: 99%

Heteroctenus junceus Scorpion Venom Modulates the Concentration of Pro-Inflammatory Cytokines in F3II Tumor Cells

Yglesias-Rivera,

Sánchez-Rodríguez,

Soto-Febles

et al. 2023

Life

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The ability of Heteroctenus junceus scorpion venom to modulate the concentration of cytokines related to its antitumoral effect is unknown. F3II cells were treated with ¼ IC50, ½ IC50 and the IC50 of H. junceus scorpion venom. Tumor growth kinetics in F3II-bearing mice were evaluated after 24 days of oral administration of venom doses. The effect of tumor lysates on F3II cell viability was evaluated by MTT assay, while cytokines present in each sample were determined by ELISA. In supernatant, H. junceus scorpion venom decreased the concentration of IL-6 (p < 0.001), IFN-γ (p < 0.001), IL-1β (p < 0.01); meanwhile IL-12 (p < 0.001) and TNF-α (p < 0.001) levels increased significantly, according to the concentration and the time of incubation. Heteroctenus junceus scorpion venom effectively inhibits in vivo tumor progression. In the sera, a significant decrease was observed in TNF-α levels (p < 0.05). In tumor lysates, IL-6 decreased significantly in the groups treated with 12.5 mg/kg (p < 0.001) and 25 mg/kg (p < 0.05). Heteroctenus junceus scorpion venom is capable of modulating other proinflammatory and protumoral cytokines involved in the inflammation associated with cancer.

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Section: Introductionmentioning

confidence: 99%