“…The studies were primarily conducted in obese/overweight adults of both sexes (mixed) which, in some cases, were also reported to be associated with other disorders such as T2D, hypertension, dyslipidaemia, etc. Some of the investigated trials were carried out using different chemical drugs (orlistat, L-carnitine, sibutramine, diacerein, hydroxychloroquine (HCQ), troglitazone, rosiglitazone, rimonabant, lacidipine, candesartan, metformin (MET) [ 29 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 ], and various other studies tested the effects of the protein/peptide-like molecules etanercept, exenatide, and liraglutide [ 176 , 177 , 178 , 179 ]. The drug intervention period varied from ≈60 d up to more than a year, and the comparison was generally done against lifestyle modifications (i.e., LCD) and/or against a widely used reference drug (i.e., MET).…”