Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential

Parry, Traci L.; Willis, Monte S.

doi:10.1016/j.bbadis.2016.07.002

Cited by 23 publications

(17 citation statements)

References 168 publications

(196 reference statements)

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“…Protein quality control mechanisms including UPS are essential to normal function of various cells, tissues, and organs through regulating synthesis, folding, trafficking, post-translational modification, assembly, disassembly, localization, and degradation of proteins (Parry & Willis, 2016). The occurrence of the pro-oxidative and proinflammatory states in cardiorenal metabolic syndrome, which include low-grade inflammation, oxidative stress, glycosylation, AGE formation, lipid peroxidation, protein oxidation, endoplasmic reticulum (ER) stress, and cytokine release, perturb the highly redox-sensitive UPS to compromise protein quality control, triggering proteotoxicity and cell injury (Hohn, et al, 2016).…”

Section: Pathophysiology Of the Cardiorenal Metabolic Syndromementioning

confidence: 99%

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Zhang

Whaley‐Connell

Sowers

et al. 2018

Pharmacology & Therapeutics

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Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation. Accumulating evidence has recently suggested a pivotal role for proteotoxicity, the unfavorable effects of poor protein quality control, in the pathophysiology of metabolic dysregulation and related cardiovascular complications. The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathways, two major although distinct cellular clearance machineries, govern protein quality control by degradation and clearance of long-lived or damaged proteins and organelles. Ample evidence has depicted an important role for protein quality control, particularly autophagy, in the maintenance of metabolic homeostasis. To this end, autophagy offers promising targets for novel strategies to prevent and treat cardiorenal metabolic diseases. Targeting autophagy using pharmacological or natural agents exhibits exciting new strategies for the growing problem of cardiorenal metabolic disorders.

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Section: Pathophysiology Of the Cardiorenal Metabolic Syndromementioning

confidence: 99%

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Zhang

Whaley‐Connell

Sowers

et al. 2018

Pharmacology & Therapeutics

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“…A majority of the proteins in cells undergo PTMs by changing their structures and functions by conformational alterations [16]. PTMs of proteins have been shown to affect mitochondrial quality control, thereby exacerbating or alleviating CVDs [17][18][19]. Therefore, the purpose of this review is to summarize the functional changes of intracellular proteins especially mitochondrialrelated proteins by PTMs and their effects on CVDs, particularly myocardial ischemia/reperfusion (I/R) injury, myocardial infarction, and heart failure.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

Liu

Zhong

Guo

2021

Oxidative Medicine and Cellular Longevity

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Cardiovascular disease (CVD) is the leading cause of death in the world. The mechanism behind CVDs has been studied for decades; however, the pathogenesis is still controversial. Mitochondrial homeostasis plays an essential role in maintaining the normal function of the cardiovascular system. The alterations of any protein function in mitochondria may induce abnormal mitochondrial quality control and unexpected mitochondrial dysfunction, leading to CVDs. Posttranslational modifications (PTMs) affect protein function by reversibly changing their conformation. This review summarizes how common and novel PTMs influence the development of CVDs by regulating mitochondrial quality control. It provides not only ideas for future research on the mechanism of some types of CVDs but also ideas for CVD treatments with therapeutic potential.

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“…With the UPS also comes the autophagy lysosome system for clearing the aberrant aggregate of proteins and damaged organelles (mitochondria) ( Varshavsky, 2017 ). Accumulating literature evidence emphasizes a key role for cellular autophagy in maintaining homeostasis of cardiac myocytes ( Parry and Willis, 2016 ). Induction of autophagy by rapamycin suppresses pressure overload induced cardiac hypertrophy in mice ( Shioi et al, 2003 ; Mcmullen et al, 2004 ), whereas knockdown of autophagic genes such as Atg5 and Atg7 has shown to induce pressure overloaded cardiomyocyte hypertrophy ( Nakai et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, for instance, an adenoviral overexpression of Atrogin-1 and MuRF1 E3 ligases suppresses the cardiac hypertrophy induced by phenylephrine treatment ( Wertz et al, 2004 ; Maejima et al, 2014 ). These studies will provide novel insight into the E3s and DUBs operated signaling cascades and their distinct role in cardiac myopathies ( Parry and Willis, 2016 ; Brown et al, 2017 ). Different components of UPS have been egressed out as significant drug targets in the treatment of cancer, immunodeficiencies, and neurodegenerative diseases ( Paul, 2008 ; Shen et al, 2013 ; Pal et al, 2014 ; Upadhyay et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Emergence of Members of TRAF and DUB of Ubiquitin Proteasome System in the Regulation of Hypertrophic Cardiomyopathy

2018

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The ubiquitin proteasome system (UPS) plays an imperative role in many critical cellular processes, frequently by mediating the selective degradation of misfolded and damaged proteins and also by playing a non-degradative role especially important as in many signaling pathways. Over the last three decades, accumulated evidence indicated that UPS proteins are primal modulators of cell cycle progression, DNA replication, and repair, transcription, immune responses, and apoptosis. Comparatively, latest studies have demonstrated a substantial complexity by the UPS regulation in the heart. In addition, various UPS proteins especially ubiquitin ligases and proteasome have been identified to play a significant role in the cardiac development and dynamic physiology of cardiac pathologies such as ischemia/reperfusion injury, hypertrophy, and heart failure. However, our understanding of the contribution of UPS dysfunction in the plausible development of cardiac pathophysiology and the complete list of UPS proteins regulating these afflictions is still in infancy. The recent emergence of the roles of TNF receptor-associated factor (TRAFs) and deubiquitinating enzymes (DUBs) superfamily in hypertrophic cardiomyopathy has enhanced our knowledge. In this review, we have mainly compiled the TRAF superfamily of E3 ligases and few DUBs proteins with other well-documented E3 ligases such as MDM2, MuRF-1, Atrogin-I, and TRIM 32 that are specific to myocardial hypertrophy. In this review, we also aim to highlight their expression profile following physiological and pathological stimulation leading to the onset of hypertrophic phenotype in the heart that can serve as biomarkers and the opportunity for the development of novel therapies.

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Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential

Cited by 23 publications

References 168 publications

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

[Retracted] The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

Emergence of Members of TRAF and DUB of Ubiquitin Proteasome System in the Regulation of Hypertrophic Cardiomyopathy

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