Cardiac troponin T levels and myocardial involvement in children with severe respiratory syncytial virus lung disease

Eisenhut, Michael; Sidaras, Dorothea; Johnson, Robert Wood; Newland, Paul; Thorburn, Kentigern

doi:10.1111/j.1651-2227.2004.tb02685.x

Cited by 34 publications

(33 citation statements)

References 24 publications

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“…Features of shock have first been described in seven infants in an observational study on 218 infants admitted to a children's hospital [3]. Elevated cardiac troponin levels were found in 35 to 54% of infants with RSV infection ventilated in PICUs [13,14]. Elevated cardiac troponin I levels have also been found in children with RSV infection not requiring mechanical ventilation [15].…”

Section: Resultsmentioning

confidence: 99%

Untitled

Eisenhut

2006

Crit Care

169

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IntroductionRespiratory syncytial virus (RSV) bronchiolitis is the most important cause for admission to the paediatric intensive care unit in infants with lower respiratory tract infection. In recent years the importance of extrapulmonary manifestations of RSV infection has become evident. This systematic review aimed at summarizing the available evidence on manifestations of RSV infection outside the respiratory tract, their causes and the changes in clinical management required.MethodsDatabases searched were Medline (1950 to present), EMBASE (1974 to present), PubMed and reference lists of relevant articles. Summarized were the findings of articles reporting on manifestations of RSV infection outside the respiratory tract in patients of all age groups.ResultsExtrapulmonary manifestations reported in previous observational studies included cardiovascular failure with hypotension and inotrope requirements associated with myocardial damage as evident from elevated cardiac troponin levels (35–54% of ventilated infants), cardiac arrhythmias like supraventricular tachycardias and ventricular tachycardias, central apnoeas (16–21% of admissions), focal and generalized seizures, focal neurological abnormalities, hyponatraemia (33%) associated with increased antidiuretic hormone secretion, and hepatitis (46–49% of ventilated infants). RSV or its genetic material have been isolated from cerebrospinal fluid, myocardium, liver and peripheral blood.ConclusionThe data summarized indicate a systemic dissemination of RSV during severe disease. Cerebral and myocardial involvement may explain the association of RSV with some cases of sudden infant death. In infants with severe RSV infection cardiac rhythm, blood pressure and serum sodium need to be monitored and supportive treatment including fluid management adjusted accordingly.

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Section: Resultsmentioning

confidence: 99%

Untitled

Eisenhut

2006

Crit Care

169

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“…7,8 Pada anak dengan pneumonia, jejas miokardium telah dilaporkan dengan penanda enzim creatinine kinase MB (CKMB) 9 dan pada anak dengan infeksi saluran nafas bawah yang disebabkan oleh Respiratory Syncytial Virus (RSV) dengan menggunakan cardiac troponin T (cTnT) sebagai penanda. 10 Pemeriksaan cTnT telah digunakan secara luas sebagai penanda yang sensitif dan spesifik untuk deteksi merusakan jaringan miokardium (kualitatif ) serta menggambarkan banyaknya jaringan yang mengalami kerusakan (kuantitatif ). 11,12 Penelitian ini bertujuan menganalisis hubungan kadar cTnT sebagai penanda jejas miokardium dengan derajat pneumonia.…”

Section: Hasilunclassified

Hubungan Kadar Cardiac Troponin T (cTnT) sebagai Penanda Jejas Miokardium dengan Derajat Pneumonia pada Anak

Erimarisya

Nataprawira

Sekarwana

2016

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Latar belakang. Hipoksemia berhubungan erat dengan pneumonia dan akan bertambah berat seiring bertambah beratnya pneumonia. Hipoksemia merupakan satu dari beberapa mekanisme yang menyebabkan komplikasi/penyulit kardiovaskular pada pneumonia. Cardiac troponin T (cTnT) telah digunakan secara luas sebagai penanda yang sensitif dan spesifik dalam deteksi kerusakan/jejas pada miokardium.Tujuan. Menganalisis hubungan kadar cTnT sebagai penanda jejas miokardium dengan derajat pneumonia.Metode. Penelitian cross-sectional dilaksanakan dari April-Juni 2013, dilibatkan 38 anak usia 2-60 bulan dengan diagnosis pneumonia dan dibagi dalam 2 kelompok, yaitu pneumonia dan pneumonia berat. Kadar cTnT serum dan pemeriksaan EKG dilakukan pada sedikitnya 72 jam awitan sesak. Analisis statistik dilakukan dengan uji Chi-kuadrat dan Mann-WhitneyHasil. Kelompok pneumonia terdiri dari 17 subjek dan pneumonia berat 21 subjek. Rerata kadar cTnT masing-masing kelompok 10,33 pg/dL dan 17,51 pg/dL (p=0,037). Proporsi subjek dengan kadar cTnT >10pg/mL dalam kelompok pneumonia berat berbeda bermakna dibandingkan kelompok pneumonia (p=0,009). Kelainan gambaran EKG ditemukan pada 8 dari 20 subjek dengan kadar cTnT >10pg/mL berupa gangguan irama, pemanjangan interval PR atau QT dan perubahan aksis jantung dan hipertrofi ventrikel kananKesimpulan. Kadar cTnT berhubungan dengan derajat pneumonia. Peningkatan kadar cTnT menunjukkan kerusakan/ jejas non-iskemik pada miokardium.

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“…Furthermore, increased susceptibility to recurrent allergic wheezing and asthma may result as a consequence of exposure to RSV infection early in life [5,9,10]. Clinical reports have also shown that RSV infection may cause extra-pulmonary effects at the neurological, endocrine, cardiac and hepatic level [11][12][13][14][15][16]. Although the causes leading to these extrapulmonary symptoms have remained elusive, it is possible that both direct organ infection by RSV and damaging inflammatory responses promoted by the virus at those tissues could contribute to the observed detrimental effects [17,18].…”

Section: Introductionmentioning

confidence: 96%