Cardiac troponin I to diagnose percutaneous transluminal coronary angioplasty-related myocardial injury

Genser, Norbert; Mair, Johannes; Talasz, Heribert; Puschendorf, Bernd; Calzolari, Charles; Larue, Catherine; Friedrich, Guy; Moes, N.; Muehlberger, Volker

doi:10.1016/s0009-8981(97)00118-6

Cited by 16 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it is necessary to re‐evaluate the possibility of PTCA‐related myocardial injury using cTnT measurements. Indeed, some previous studies have reported that cTnT levels did not increase in the peripheral blood serum in uncomplicated PTCA 10–13 . However, in these studies, cTnT was measured in the peripheral blood and not in the CS.…”

Section: Discussionmentioning

confidence: 84%

“…In contrast, it has been shown that angiographically visible occlusion of minor side branches leads to a moderate increase of cTnT 10–13 . In the present study, in addition to the 16 patients with uncomplicated PTCA, we evaluated three patients who had minor complications.…”

Section: Discussionmentioning

confidence: 89%

“…Recent studies have used cTnT measurements to show that minor myocardial injury can be caused by successful PTCA 7–9 . Other studies have shown that these injuries are due to minor complications and that uncomplicated successful PTCA does not cause elevation of cTnT 10–13 . However, these reports evaluated myocardial damage by measuring cTnT in peripheral veins.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Troponin T In The Coronary Sinus And Percutaneous Transluminal Coronary Angioplasty Related Myocardial Injury

Katoh

Shimada

Sano

et al. 2000

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. Myocardial injury has been shown to be associated with successful percutaneous transluminal coronary angioplasty (PTCA). The present study was designed to determine whether uncomplicated successful PTCA results in myocardial injury by measuring coronary sinus (CS) cardiac troponin T (cTnT). 2. We measured cTnT in the CS and the femoral vein (FV) in 16 patients with stable angina pectoris who underwent uncomplicated PTCA for stenotic lesions of the left anterior descending artery. Blood samples were drawn from both the CS and FV before and immediately after PTCA and every 4 h for the next 12 h. 3. All patients had chest pain and electrocardiographic ST segment elevation or depression during balloon inflation and higher peak elevation of cTnT in the CS than in the FV (0.054 +/- 0.059 vs 0.036 +/- 0.022 ng/mL; P < 0.05). However, all CS cTnT levels were within the normal range over the 12 h period. 4. The fact that CS cTnT measurements showed no evidence of uncomplicated PTCA-related myocardial injury led us to conclude that uncomplicated successful PTCA does not cause myocardial injury.

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Troponin T In The Coronary Sinus And Percutaneous Transluminal Coronary Angioplasty Related Myocardial Injury

Katoh

Shimada

Sano

et al. 2000

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…Genser ve ark. [18] CKMB, cTnT ve cTnI düzeylerini karşılaştırdığı bir çalışmada semptomsuz minör yan dal oklüzyonu olan hastaların yarısında her üç parametrenin de orta derecede arttığını, akut damar tıkanması veya MI olan hastaların tamamında ise tüm belirteçlerin belirgin derecede arttığını bildirmişlerdir.…”

Section: Bulgularunclassified

Investigation of cardiac markers cut off values in the diagnosis of acute coronary syndrome

Şahi̇n¹,

Kabalcı²,

Savcı³

2018

Ortadogu Tıp Derg

View full text Add to dashboard Cite

ÖzAmaç: Akut göğüs ağrısı şikâyeti ile acil servise başvuran hasta sayısı oldukça fazladır ancak bunların çoğu akut koroner sendrom (AKS) tanısı almaz. Gerçek kardiyak hastaları belirleyebilmek için ilk aşamada non-kardiyak nedenleri dışlamak gerekir. Troponinler, kalp kasının yapısal proteinleri olup kardiyak hasara duyarlı veözgün molekülleridir. Bu çalışmada AKS tanısı için Kreatin kinaz MB (CKMB) testinin kesme değerini kardiyak troponin T (cTnT) sonuçlarından ve ROC analizinden faydalanarak belirlemeyi amaçladık. Ayrıca akut miyokard infarktüsü (AMI) hasta yönetiminde kardiyak belirteçlerin ve klinik bilgilerin birlikte kullanımını değerlendirdik. Gereç ve Yöntem:Akut göğüs ağrısı ileacil servise başvuran 390 hastanın elektrokardiyografi (EKG) ve kardiyak belirteçler (cTnT, CKMB seviyeleri) de dâhil olmak üzere laboratuvar ve klinik verileri retrospektif olarak toplandı ve bu veriler kullanılarak bir strateji geliştirmeye çalışıldı. Olgular (yaş:58.65 ± 13,29) iki gruba ayrıldı: birinci grup AMI ve ikinci grup iskemik hasar olmayanlardı. CKMB seviyeleri Dimension Xpand Plus (Dade Behring Inc, Newark, ABD) marka biyokimya otoanalizöründe immünoinhibisyon yöntemiyle ölçüldü. cTnT için Cardiac T Quantitative Rapid Assay (Roche Diagnostics GmbH, Mannheim, Almanya) hasta başı cihazı kullanıldı.Bulgular: Çalışmamızda 390 hastanın 36'sında (% 9,2) AMI saptandı. AMI öngörmede CKMB'nin tanısal özgüllüğü ve tanısal duyarlılığı, 16 U/L düzeyi için %92 ve %44; 12 U/L düzeyi için %86 ve %50; 9 U/L düzeyi için %79 ve %61; 6 U/L düzeyi için%63 ve%69 olarak bulundu. CKMB için eğri altındaki alan 0,72 (SE:0,055, p<0,001) idi.Sonuç: Acil serviste AMI erken teşhisinde her ne kadar cTnT en önemli marker olsa da CKMB düzeyleri de hem yalancı negatifliği hem de yalancı pozitifliği azaltmak için birlikte kullanılması gereken güvenilir bir markerdir. Anahtar Kelimeler: Akut koroner sendrom, kardiyak troponin, kreatin kinaz MB, duyarlılık, özgüllük Akut koroner sendrom tanısında kardiyak belirteçlerin kesme değerlerinin incelenmesi 247 ORTADOĞU TIP DERGİSİ 10 (3): 247-251 2018Result: In our study, AMI was detected in 36 of 390 patients (9.2%). In prediction of AMI, the diagnostic specificity and diagnostic sensitivity of CKMB was 92% and 44% for 16 U/L; 86% and 50% for 12 U/L; 79% and 61% for 9 U/L, 63% and 69% for 6 U/L, respectively.The area under the curve for CKMB was 0.72 (SE: 0.055, p <0.001). Conclusion:Although cTnT is the most important marker in early diagnosis of AMI in emergency department, CKMB levels are a reliable marker that should be used together to reduce both false negative and false positives.

show abstract

“…In the uncomplicated cases, concentrations of cTnI and cTnT usually do not rise above baseline values (83,84); on the contrary, complications seem to be associated with cTnI elevation: for example, this marker rises in about 50% of the patients with clinically symptomless side branch occlusion (85). In the uncomplicated cases, concentrations of cTnI and cTnT usually do not rise above baseline values (83,84); on the contrary, complications seem to be associated with cTnI elevation: for example, this marker rises in about 50% of the patients with clinically symptomless side branch occlusion (85).…”

Section: Assessment Of Myocardial Damage After Percutaneous Translumimentioning

confidence: 99%

Cardiac Troponin I and Troponin T: Recent Players in the Field of Myocardial Markers

Chapelle¹

1999

CCLM

View full text Add to dashboard Cite

The troponin (Tn) complex consists of three subunits referred to as TnT, TnI and TnC. Myocardium contains TnT and TnI isoforms which are not present in skeletal muscles and which can be separated from the muscular isoforms by immunological techniques. Using commercially available immunoassays, clinical laboratories are able to determine cardiac TnT and TnI (cTnT and cTnI) quickly and reliably as classical cardiac markers. After acute myocardial infarction, cTnT and cTnI concentrations start to increase in serum in a rather similar way than CK-MB, but return to normal after longer periods of time (approximately one week). Because of their excellent cardiac specificity, Tn subunits appear ideally suited for the differential diagnosis of myocardial and muscular damage, for example in noncardiac surgery patients, in patients with muscular trauma or with chronic muscular diseases, or after intense physical exercise. cTnT and cTnI may also be used for detecting evidence of minor myocardial damage: therefore they have found new clinical applications, in particular risk stratification in patients with unstable angina. In spite of the possible reexpression of cTnT in human skeletal muscles, and of the lack of standardization of cTnI assays, Tn subunits are not far to meet the criteria of ideal markers for acute myocardial injury. Only an insufficient sensitivity in the first hours following the acute coronary syndroms requiries to maintain an early myocardial marker in the cardiac panel for routine laboratory testing.

show abstract

Cardiac troponin I to diagnose percutaneous transluminal coronary angioplasty-related myocardial injury

Cited by 16 publications

References 16 publications

Troponin T In The Coronary Sinus And Percutaneous Transluminal Coronary Angioplasty Related Myocardial Injury

Troponin T In The Coronary Sinus And Percutaneous Transluminal Coronary Angioplasty Related Myocardial Injury

Investigation of cardiac markers cut off values in the diagnosis of acute coronary syndrome

Cardiac Troponin I and Troponin T: Recent Players in the Field of Myocardial Markers

Contact Info

Product

Resources

About