Cardiac troponin I in three cat breeds with hypertrophic cardiomyopathy

Langhorn, Rebecca; Willesen, Jakob L.; Tarnow, Inge; Kjelgaard‐Hansen, Mads; Koch, J.

doi:10.1136/vr.103549

Cited by 3 publications

(10 citation statements)

References 13 publications

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“…Regarding the distribution of cTnI in healthy cats, a previous study found that neither sex nor age significantly affected the cTnI concentration in 35 healthy cats; also, the concentration was not affected by breed (British Shorthairs, Maine Coons, and Norwegian Forest Cats). 17 We studied a large population of healthy cats and found that the cTnI concentration varied significantly by body weight. One possible explanation for this finding is that heavier cats may exhibit more ventricular hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a highly sensitive immunoassay for cTnI, the ADVIA Centaur CP TnI-Ultra assay (Siemens Healthineers Japan, Tokyo, Japan), has been described. 16,17 It is a 3-site, second generation sandwich immunoassay employing direct chemiluminometry; the lower limit of cTnI detection is 0.006 ng/mL. Compared with the conventional assay, 13,14 the cTnI assay allows highly sensitive evaluation of a specific marker of low-grade myocardial injury.…”

Section: In Humansmentioning

confidence: 99%

“…Recently, a highly sensitive immunoassay for cTnI, the ADVIA Centaur CP TnI‐Ultra assay (Siemens Healthineers Japan, Tokyo, Japan), has been described . It is a 3‐site, second generation sandwich immunoassay employing direct chemiluminometry; the lower limit of cTnI detection is 0.006 ng/mL.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy

Hori

Iguchi²,

Heishima

et al. 2018

Veterinary Internal Medicne

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BackgroundCardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats.ObjectiveTo measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM.AnimalsClinically healthy cats (n = 88) and cats with HCM (n = 93).MethodsMulticenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography. Plasma cTnI concentrations were analyzed by a commercial laboratory. Receiver‐operating characteristic curve analysis was used to evaluate the accuracy of plasma cTnI concentrations to detect HCM.ResultsThe median cTnI concentration was 0.027 ng/mL (interquartile range, 0.012‐0.048 ng/mL) in healthy cats. Concentrations were significantly higher in diseased cats than in healthy controls, and concentrations were significantly higher in cats with heart failure than in asymptomatic cats. A plasma cTnI concentration of 0.163 ng/mL had a sensitivity of 62.0% and specificity of 100% when used to distinguish normal cats from asymptomatic HCM cats without left atrial dilatation. A cutoff of 0.234 ng/mL had high sensitivity (95.0%) and specificity (77.8%) for assessing heart failure. The areas under the receiver‐operating characteristic curves were 0.85 and 0.93, respectively.Conclusions and Clinical ImportanceIncreased cTnI concentrations reflect the severity of HCM. If other causes of cardiac injury are ruled out, plasma cTnI concentration may be useful for predicting the severity of HCM in cats.

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Section: Discussionmentioning

confidence: 99%

Section: In Humansmentioning

confidence: 99%

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Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy

Hori

Iguchi²,

Heishima

et al. 2018

Veterinary Internal Medicne

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“…Feline hypertrophic cardiomyopathy appears to have a breed predisposition, as does canine DCM and is, reportedly, the most common cardiac disorder in cats and has shown remarkable similarities to human HCM [ 19 ]. The familial predisposition is most obvious in Maine Coon, Ragdoll, and British and American Shorthair breeds [ 23 , 24 , 25 ]. Separate genetic mutations have been identified as causal of HCM in the Maine Coon and Ragdoll breeds within the MYBPC3 gene [ 24 , 26 ] but there are also affected individuals within the Maine Coon breed lacking the mutation, indicating that there are additional causes of the disease to be established [ 27 ].…”

Section: Hypertrophic Cardiomyopathy (Hcm)mentioning

confidence: 99%

“…This is important, considering that an estimated 35% of human cases are caused by MYBPC3 mutations [ 16 ]. Higher concentrations of cTnI have also been observed in some breeds of cats with HCM [ 25 , 29 ], but no mutations have been observed in that gene in Maine Coons or British Shorthairs [ 25 ], whereas mutations in this gene have been observed in humans. Pigs also appear to have a heritable form of HCM, but no specific genetic associations have been discovered to date [ 30 ].…”

Section: Hypertrophic Cardiomyopathy (Hcm)mentioning

confidence: 99%

Genomic Insights into Cardiomyopathies: A Comparative Cross-Species Review

Simpson

Rutland

2017

Veterinary Sciences

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In the global human population, the leading cause of non-communicable death is cardiovascular disease. It is predicted that by 2030, deaths attributable to cardiovascular disease will have risen to over 20 million per year. This review compares the cardiomyopathies in both human and non-human animals and identifies the genetic associations for each disorder in each species/taxonomic group. Despite differences between species, advances in human medicine can be gained by utilising animal models of cardiac disease; likewise, gains can be made in animal medicine from human genomic insights. Advances could include undertaking regular clinical checks in individuals susceptible to cardiomyopathy, genetic testing prior to breeding, and careful administration of breeding programmes (in non-human animals), further development of treatment regimes, and drugs and diagnostic techniques.

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Cardiac troponin I in healthy Norwegian Forest Cat, Birman and domestic shorthair cats, and in cats with hypertrophic cardiomyopathy

Hanås

Larsson

Rydén

et al. 2022

Journal of Feline Medicine and Surgery

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Objectives The aims of this study were to assess the potential associations between the serum cardiac troponin I (cTnI) concentration in healthy cats and feline characteristics, systolic blood pressure, heart rate (HR), echocardiographic measurements and storage time; and to compare cTnI concentrations in healthy cats with concentrations in cats with hypertrophic cardiomyopathy (HCM), with or without left atrial enlargement (LAE) and in cats with HCM, to assess potential associations between cTnI concentration and echocardiographic variables. Methods Cardiac TnI was analysed using an Abbott ARCHITECT ci16200 analyser in serum from prospectively included healthy Norwegian Forest Cat (NF; n = 33), Birman (n = 33) and domestic shorthair (DSH; n = 30) cats, and from 39 cats with HCM, with or without LAE. Results In healthy cats, higher cTnI concentrations were found in Birman cats than in NF cats ( P = 0.014) and in neutered male cats than in intact females ( P = 0.032). Cardiac TnI was positively associated with HR ( P <0.0001). In cats with HCM, cTnI concentration was positively associated with left ventricular wall thickness and with left atrial-to-aortic root ratio (all P ⩽0.010). Cats with HCM had higher cTnI concentrations than healthy cats, and cTnI concentrations were higher in cats with HCM and LAE than in those with HCM without LAE (all P = 0.0003). Conclusions and relevance Breed and sex may affect serum cTnI concentrations in healthy cats. The cTnI concentration increased with increasing severity of HCM.

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Cardiac troponin I in three cat breeds with hypertrophic cardiomyopathy

Abstract: Part of the troponin I data reported in this study has been previously published as the baseline data in a prospective cohort study: Langhorn and others (2014).

Cited by 3 publications

References 13 publications

Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy

Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy

Genomic Insights into Cardiomyopathies: A Comparative Cross-Species Review

Cardiac troponin I in healthy Norwegian Forest Cat, Birman and domestic shorthair cats, and in cats with hypertrophic cardiomyopathy

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