Cardiac Troponin I in Patients With Acute Lower Limb Ischemia

Editor's Choice – European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia

“…54 In a series of 46 patients with ALI undergoing embolectomy, cardiac troponin I was > 0.2 ng/mL in 24 but did not have prognostic value with regard to in hospital mortality. 55 A correlation with limb salvage was not studied. C reactive protein (CRP) and alpha-1-acid glycoprotein levels were studied in 75 patients with acute arterial occlusion.…”

Troponin status predicts 30-day in-hospital mortality

“…Published studies on the prognostic value of troponin encompass a range of different clinical conditions [7][8][9][10][11][12][13][14][15][16][17][18][19][20] , many of which are primary cardiac conditions such as congestive heart failure) [20] , myocarditis [18] , aortic stenosis [43] and atrial fibrillation without coronary disease [17] . Troponin has most obviously been shown to be a prognostic marker in myocardial infarction [44] .…”

“…Cardiacspecific troponins have utility because they combine value as a near ideal biologic marker, and also convey useful prognostic information that can influence therapeutic decision making [5] . Troponin assays were initially developed for their utility in acute coronary syndromes [6] , however, it was quickly recognized that a range of other medical conditions were also associated with troponin elevation [7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Although troponin elevation signifies cardiac damage, it may not always imply cardio-specificity with predictive values as low as 56% in the diagnosis of acute coronary syndromes [21] .…”