Cardiac troponin I in diagnosis of perioperative myocardial infarction after cardiac surgery

Alyanakian, Marie‐Alexandra; Dehoux, Monique; Chatel, Didier; Seguret, Christophe; Desmonts, Jean-Marie; Durand, Geneviève; Philip, Ivan

doi:10.1016/s1053-0770(98)90008-8

Cited by 97 publications

(42 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…cTnI, a contractile protein unique to the heart muscle, is a sensitive biomarker, which was introduced predominantly for risk stratification in patients exhibiting acute coronary syndrome and is the gold standard for identifying MI (18,19); in addition, ACE2 is expressed in the heart and has been observed to exhibit a protective effect during MI (8–11). Increasing evidence indicates that the expression of cardiac ACE2 is higher following MI, which combats the adverse effects of an activated cardiac RAS and, therefore, may be a compensatory mechanism in MI (8–11,15,20).…”

Section: Discussionmentioning

confidence: 99%

Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting

Wang

Zhang

Zhou

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Myocardial infarction (MI) is a predominant and severe complication in patients that undergo aortocoronary bypass surgery. Angiotensin-converting enzyme 2 (ACE2) activation is reportedly a protective mechanism in MI; therefore, in the present study, the association between serum ACE2 levels and postoperative MI following coronary artery bypass grafting (CABG) was investigated. Preoperative and postoperative serum ACE2 levels in 136 subjects undergoing CABG were observed and the serum ACE2 levels, 1 h post surgery, were divided into quartile categories. Following adjustment for age, gender, body mass index, hypertension, previous MI, current smoking status, hyperlipidemia, diabetes mellitus, Gensini score, aortic clamp time, number of grafts and pre-CABG medications; the risk of developing postoperative MI following CABG was observed to be significantly higher in the lowest serum ACE2 level quartile than when compared with the highest quartile (hazard ratio, 2.94; 95% confidence interval, 1.85–4.16; P=0.009). The subjects that exhibited a serum ACE2 level ≤1.06 ng/ml showed significantly higher rates of postoperative MI, arrhythmia and reduced cardiac output in addition to increased instances of in-hospital mortality post CABG, compared with those exhibiting a serum ACE2 level >1.06 ng/ml. A significant negative correlation was observed between serum ACE2 and serum cardiac troponin I levels, however, no significant association was identified between the serum ACE2 level quartiles and the ACE2 gene polymorphisms. The present study indicated that a low serum ACE2 level, 1 h post CABG was independently associated with an increased risk of postoperative MI. Thus, the serum ACE2 level may be a potential novel prognostic factor for postoperative MI following CABG.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting

Wang

Zhang

Zhou

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…In most publications, it was dichotomized with values ranging from 1.5 to 5.0 ng/mL [27][28][29][30][31] . In the present study, we used cutoff points in different percentiles; however, this did not change its pattern in either group.…”

Section: Discussionmentioning

confidence: 99%

Behavior of inflammatory markers of myocardial injury in cardiac surgery: laboratory correlation with the clinical picture of postpericardiotomy syndrome

Köhler¹,

Saraiva²,

Wender³

et al. 2003

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

OBJECTIVE: To verify the association of serum markers of myocardial injury, such as troponin I, creatinine kinase, and creatinine kinase isoenzyme MB, and inflammatory markers, such as tumor necrosis factor alpha (TNF-alpha), C-reactive protein, and the erythrocyte sedimentation rate in the perioperative period of cardiac surgery, with the occurrence of possible postpericardiotomy syndrome. METHODS: This was a cohort study with 96 patients undergoing cardiac surgery assessed at the following 4 different time periods: the day before surgery (D0); the 3rd postoperative day (D3); between the 7th and 10th postoperative days (D7-10); and the 30th postoperative day (D30). During each period, we evaluated demographic variables (sex and age), surgical variables (type and duration , extracorporeal circulation), and serum dosages of the markers of myocardial injury and inflammatory response. RESULTS: Of all patients, 12 (12.5%) met the clinical criteria for a diagnosis of postpericardiotomy syndrome, and their mean age was 10.3 years lower than the age of the others (P=0.02). The results of the serum markers for tissue injury and inflammatory response were not significantly different between the 2 assessed groups. No significant difference existed regarding either surgery duration or extracorporeal circulation. CONCLUSION: The patients who met the clinical criteria for postpericardiotomy syndrome were significantly younger than the others were. Serum markers for tissue injury and inflammatory response were not different in the clinically affected group, and did not correlate with the different types and duration of surgery or with extracorporeal circulation

show abstract

“…In non-cardiac surgery, any increase in cTnI above the normal range must be considered as an indication of myocardial necrosis [3]. In cardiac surgery with cardiopulmonary bypass (CPB), the issue is far more complex since cardiac surgery and CPB can induce an increase in postoperative cTnI, even in the absence of postoperative cardiac complications [4][5][6][7]. This increase depends on the type of surgery and its subsequent degree of direct surgical trauma [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have previously described the kinetics of cTnI elevation in the plasma after cardiac surgery [4][5][6]. In case of significant myocardial infarction, peak levels of cTnI occur nearly 20-24 h after the end of surgery [5,14].…”

Section: Introductionmentioning

confidence: 99%

Kinetic analysis of cardiac troponin I release is no more accurate than a single 24-h measurement in predicting in-hospital outcome after cardiac surgery

Hanouz¹,

Gue²,

Monier³

et al. 2008

European Journal of Anaesthesiology

View full text Add to dashboard Cite

show abstract

Cardiac troponin I in diagnosis of perioperative myocardial infarction after cardiac surgery

Cited by 97 publications

References 25 publications

Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting

Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting

Behavior of inflammatory markers of myocardial injury in cardiac surgery: laboratory correlation with the clinical picture of postpericardiotomy syndrome

Kinetic analysis of cardiac troponin I release is no more accurate than a single 24-h measurement in predicting in-hospital outcome after cardiac surgery

Contact Info

Product

Resources

About