Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog

Spratt, David P.; Mellanby, Richard J.; Drury, Nigel E; Archer, Joy

doi:10.1111/j.1748-5827.2005.tb00304.x

Cited by 130 publications

(126 citation statements)

References 51 publications

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“…5,18,21 Veterinary cardiology has witnessed a recent interest in the role of cardiac biomarkers in assessing cardiac status of veterinary patients. 2 Various investigators have examined the ability of atrial or brain natriuretic peptides 3,8,9,12 or of cTnI or cTnT 17,18,20,22 to either identify cardiac disease status or prognosticate on outcome in patients with myocardial damage. In addition, equine myocardial injury with performance or disease has been increasingly investigated by measuring cTnI.…”

mentioning

confidence: 99%

Cloning and Sequencing of Equine Cardiac Troponin I and Confirmation of Its Usefulness as a Target Analyte for Commercial Troponin I Analyzers

Rishniw

Simpson

2005

J VET Diagn Invest

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Abstract. The analysis of cardiac troponin I (cTnI) in the diagnosis of myocardial injury in domestic animals is gaining popularity. In this study, equine cTnI was sequenced and compared with previously characterized cTnI from other species. A 6-amino-acid N-terminal deletion unique to the horse was identified. This deletion was outside the epitope region of cTnI recognized by most commercial immunoassays and did not affect the ability of a commercial analyzer system to detect recombinant equine cTnI. No function could be ascribed to the deleted portion. These data support the use of commercial analyzers in measuring equine cTnI.

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confidence: 99%

Cloning and Sequencing of Equine Cardiac Troponin I and Confirmation of Its Usefulness as a Target Analyte for Commercial Troponin I Analyzers

Rishniw

Simpson

2005

J VET Diagn Invest

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“…Following cardiac injury, troponins are released into the circulation from damaged myocytes. Elevated levels are detectable in the blood within four hours of cardiac damage and reach a peak value within 12 to 24 hours, and then slowly decline over the next five to 20 days, depending on the degree of initial damage (30,31,33). In our study, positive rate of cTn-I level was detected in non-survival dogs.…”

Section: Discussionmentioning

confidence: 52%

Prognostic usefulness of some parameters in dogs with canine parvovirus

Baştan

Kurtdede

Özen

2013

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The purpose of this study was to evaluate the prognostic usefulness of some parameters in dogs with canine parvovirus (CPV). Fifty-nine animals which consist of 39 ill and 20 healthy puppies were used in the study. All puppies were underwent a complete physical examination and laboratory variables (CBC, serum routine biochemistry profile, cTn-I, TNF-α) on their first admission to clinic and on following every day before treatment until discharge or death. Despite aggressive treatment with available therapy, 14 of 39 dogs died. Non-survivor dogs had significantly lower leukocyte, lymphocyte, monocyte and granulocyte counts but had significantly higher serum urea and creatinine concentrations than those of survivor dogs at presentation (p<0.05). Serum cTn-I concentration level were positive in 11of 14 non-survival dogs and negative in all of the survival dogs. The relative risk of death for the dogs with TNF-α positive was 3,39 times (95% CI:1,53-7,52) higher than that of dogs with TNF-α negative. This study demonstrates that leukocyte, lymphocyte, granulocyte, monocyte counts, serum urea and creatinine concentrations, cTn-I and TNF-α levels are useful parameters for predicting the prognosis of dogs with CPV.

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“…It should be noted, however, that cardiac neoplasia in general does not readily exfoliate, and also that reactive mesothelial cells from the pericardial cavity commonly are misdiagnosed as being neoplastic [19]. Different parameters, including pH and cardiac troponins, have been assessed with varying success as potentially useful indicators of etiology in pericardial effusion [17,[29][30][31][32][33]. Unfortunately, the overall diagnostic value of pericardial fluid analysis remains quite low for detecting most tumors, and results should in general be interpreted cautiously.…”

Section: Resultsmentioning

confidence: 99%

Interventional Treatment of Pericardial Effusion

Linde

Melgarejo

2010

SRX Veterinary Science

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Pericardial effusion involves fluid accumulation within the pericardial sac, and may be a fatal condition pending the volume of accumulated fluid, the chronicity, and whether timely therapy is instituted. The frequency and etiology of pericardial effusion cases can vary quite significantly, not only between different species but also among diverse geographical areas. The often fragile clinical state of patients within this category requires instantaneous and efficacious therapy involving a minimum of stress. The gold standard for immediate ambulatory treatment of compromising pericardial effusion is percutaneous pericardiocentesis, which is the focus of this brief methodology paper. The techniques used for performing pericardiocentesis and pericardial lavage in small and large animals species, respectively, are described.

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Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog

Abstract: Measurement of blood cTnl levels may be a useful aid in the diagnosis of dogs with suspected heart disease and in indicating the severity of heart failure.

Cited by 130 publications

References 51 publications

Cloning and Sequencing of Equine Cardiac Troponin I and Confirmation of Its Usefulness as a Target Analyte for Commercial Troponin I Analyzers

Cloning and Sequencing of Equine Cardiac Troponin I and Confirmation of Its Usefulness as a Target Analyte for Commercial Troponin I Analyzers

Prognostic usefulness of some parameters in dogs with canine parvovirus

Interventional Treatment of Pericardial Effusion

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