Cardiac troponin i as a predictor of respiratory failure in children hospitalized with respiratory syncytial virus (RSV) infections: a pilot study

Moynihan, James A.; Brown, Lance; Sehra, Ruchir; Checchia, Paul A.

doi:10.1016/s0735-6757(03)00163-3

Cited by 20 publications

(17 citation statements)

References 26 publications

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“…Increased serum level of cTp I in severe group of the present study is in line with previous studies that demonstrated elevation in cTp I in RSV bronchiolitis (Checchia et al, 2000;Moynihan et al, 2003). Initially, increased levels of cTp I were presumed to be due to myocardial necrosis, as happens in myocardial infarction (Martins et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

Impact of Acute Bronchiolitis on Cardiac Functions and Serum microRNA-122 and 499

Mohamed¹,

Zayed²

2016

American Journal of Infectious Diseases

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Abstract:Bronchiolitis is an acute inflammatory injury of the bronchioles that is usually caused by a viral infection, most commonly Respiratory Syncytial Virus (RSV). This study aimed to verify the direct injurious effect of acute bronchiolitis on the myocardium and serum level of microRNA-122 and 499 (miR-122 and miR-499) of infected infants. Serum lactate dehydrogenase (LDH), creatine phosphokinase-isoenzyme MB (CK-MB) and cardiac troponin I (cTp I) were significantly elevated in mild to moderate group as well as severe group except cTp I which showed nonsignificant elevation in mild to moderate group, compared to control group. Quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR) was carried out to evaluate the serum level of miR-122 and miR-499. Sharp elevation in serum miR-122 was observed in severe cases, while miR-499 was statistically non-significant as compared to both normal and mild to moderate groups. The flow velocities across the pulmonary, tricuspid and mitral valves were recorded using standard echocardiographic techniques. Echocardiographic data showed significant reduction in pulmonary At/Et ratio in severe bronchiolitis group, compared to both normal and mild to moderate groups, respectively. Parallel reduction was also observed in tricuspid and mitral E/A ratios, compared to both normal and mild to moderate groups, respectively. Severe bronchiolitis causes cardiac dysfunction due to hypoxia, cardiac strain and pulmonary hypertension in addition to up-regulation of serum miRNA-122.

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Section: Discussionsupporting

confidence: 92%

Impact of Acute Bronchiolitis on Cardiac Functions and Serum microRNA-122 and 499

Mohamed¹,

Zayed²

2016

American Journal of Infectious Diseases

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“…Elevated cardiac troponin levels were found in 35 to 54% of infants with RSV infection ventilated in PICUs [13,14]. Elevated cardiac troponin I levels have also been found in children with RSV infection not requiring mechanical ventilation [15]. The degree of cardiovascular support described ranged from the administration of fluid boluses [14] to inotropic support [13,16].…”

Section: Resultsmentioning

confidence: 99%

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Eisenhut

2006

Crit Care

170

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IntroductionRespiratory syncytial virus (RSV) bronchiolitis is the most important cause for admission to the paediatric intensive care unit in infants with lower respiratory tract infection. In recent years the importance of extrapulmonary manifestations of RSV infection has become evident. This systematic review aimed at summarizing the available evidence on manifestations of RSV infection outside the respiratory tract, their causes and the changes in clinical management required.MethodsDatabases searched were Medline (1950 to present), EMBASE (1974 to present), PubMed and reference lists of relevant articles. Summarized were the findings of articles reporting on manifestations of RSV infection outside the respiratory tract in patients of all age groups.ResultsExtrapulmonary manifestations reported in previous observational studies included cardiovascular failure with hypotension and inotrope requirements associated with myocardial damage as evident from elevated cardiac troponin levels (35–54% of ventilated infants), cardiac arrhythmias like supraventricular tachycardias and ventricular tachycardias, central apnoeas (16–21% of admissions), focal and generalized seizures, focal neurological abnormalities, hyponatraemia (33%) associated with increased antidiuretic hormone secretion, and hepatitis (46–49% of ventilated infants). RSV or its genetic material have been isolated from cerebrospinal fluid, myocardium, liver and peripheral blood.ConclusionThe data summarized indicate a systemic dissemination of RSV during severe disease. Cerebral and myocardial involvement may explain the association of RSV with some cases of sudden infant death. In infants with severe RSV infection cardiac rhythm, blood pressure and serum sodium need to be monitored and supportive treatment including fluid management adjusted accordingly.

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“…In another series of children with meningococcal sepsis, Thiru and colleagues (119) found that cTnI was increased at admission to a degree similar to that we have found in septic shock (24% at admission, 62% within the first 2 days of illness), but ischemic heart disease was not excluded in these children. Additionally, troponin elevation has been demonstrated in children with a septiclike picture associated with respiratory syncytial virus infection (120,121).…”

Section: Troponin In Nonischemic Cardiac Conditionsmentioning

confidence: 99%

Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance

Domico¹,

Checchia²

2011

Pediatric Critical Care Medicine

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Cardiac troponin i as a predictor of respiratory failure in children hospitalized with respiratory syncytial virus (RSV) infections: a pilot study

Cited by 20 publications

References 26 publications

Impact of Acute Bronchiolitis on Cardiac Functions and Serum microRNA-122 and 499

Impact of Acute Bronchiolitis on Cardiac Functions and Serum microRNA-122 and 499

Untitled

Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance

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